Frontiers in Oncology,
Год журнала:
2022,
Номер
12
Опубликована: Сен. 23, 2022
Over
the
past
two
decades,
there
has
been
a
tendency
toward
early
diagnosis
of
prostate
cancer
due
to
raised
awareness
among
general
public
and
professionals,
as
well
promotion
prostate-specific
antigen
(PSA)
screening.
As
result,
patients
with
are
detected
at
an
earlier
stage.
Due
risks
urine
incontinence,
erectile
dysfunction,
etc.,
surgery
is
not
advised
because
tumor
so
small
this
Doctors
typically
only
advise
active
surveillance.
However,
it
will
bring
negative
psychological
effects
on
patients,
such
anxiety.
And
higher
chance
progression.
Focal
therapy
received
increasing
attention
alternative
option
between
monitoring
radical
therapy.
its
minimally
invasive,
oncological
safety,
low
toxicity,
minimal
functional
outcomes
support
by
level
1
evidence
from
RCT
within
focal
literature,
photodynamic
treatment
(PDT)
holds
significant
promise
choice
over
other
modalities
for
men
localized
cancer.
still
numerous
obstacles
that
prevent
further
advancement.
The
review
follows
provides
overview
preclinical
clinical
published
research
PDT
1999
present.
It
focuses
applications
innovative
techniques
technologies
address
current
problems,
especially
use
nanoparticle
photosensitizers
in
Advanced Functional Materials,
Год журнала:
2021,
Номер
31(51)
Опубликована: Сен. 14, 2021
Abstract
Metal
nanoclusters
(NCs)
have
recently
attracted
great
interest
in
biomedical
applications
due
to
their
ultrasmall
size,
good
biocompatibility,
and
unique
molecule‐like
physical
chemical
properties.
NCs
can
be
rationally
designed
integrated
with
various
targeting
moieties
achieve
physicochemical
properties
functions.
For
therapeutic
applications,
these
multifunctional
surface‐modified
provide
distinctive
advantages
over
native
metal
NCs,
such
as
improved
effects
reduced
side
effects.
In
this
review,
the
design
principles
of
strategies
for
composites,
including
passive
active
targeting,
are
first
discussed.
The
authors
then
focus
on
recent
achievements
application
targeted
therapeutics,
chemotherapy,
phototherapy,
radiotherapy.
Finally,
authors’
perspectives
challenges
opportunities
developing
further
paving
way
potential
clinical
provided.
ACS Nano,
Год журнала:
2022,
Номер
16(9), С. 15026 - 15041
Опубликована: Авг. 29, 2022
The
exciting
success
of
NBTXR3
in
the
clinic
has
triggered
a
tumult
activities
design
and
development
hafnium-based
nanoparticles.
However,
due
to
concerns
nondegradation
limited
functions,
biomedical
applications
Hf-based
nanoparticles
mainly
focus
on
tumors.
Herein,
tannic
acid
capped
hafnium
disulfide
(HfS2@TA)
nanosheets,
2D
atomic
crystal
materials
prepared
by
liquid-phase
exfoliation,
were
explored
as
high-performance
anti-inflammatory
nanoagents
for
targeted
therapy
inflammatory
bowel
disease
(IBD).
Benefiting
from
transformation
S2–/S6+
valence
state
huge
specific
surface
area,
obtained
HfS2@TA
nanosheets
not
only
capable
effectively
eliminating
reactive
oxygen
species/reactive
nitrogen
species
downregulating
pro-inflammatory
factors
but
also
could
be
excreted
via
kidney
hepatointestinal
systems.
Unexpectedly,
maintained
excellent
targeting
capability
an
inflamed
colon
even
harsh
digestive
tract
environment,
attributed
electrostatic
interactions
between
negatively
charged
positively
epithelium.
Encouragingly,
upon
oral
or
intravenous
administration,
quickly
inhibited
inflammation
repaired
intestinal
mucosa
barrier
both
dextran
sodium
sulfate
2,4,6-trinitrobenzenesulfonic
induced
IBD
models.
This
work
demonstrated
that
ultrathin
crystals
with
enhanced
accumulation
promising
IBD.
Molecules,
Год журнала:
2023,
Номер
28(6), С. 2733 - 2733
Опубликована: Март 17, 2023
Rhenium
(Re)
is
widely
used
in
the
diagnosis
and
treatment
of
cancer
due
to
its
unique
physical
chemical
properties.
Re
has
more
valence
electrons
outer
shell,
allowing
it
exist
a
variety
oxidation
states
form
different
geometric
configurations
with
many
ligands.
The
luminescence
properties,
lipophilicity,
cytotoxicity
complexes
can
be
adjusted
by
changing
ligand
Re.
This
article
mainly
reviews
development
radionuclide
188Re
radiotherapy
some
innovative
applications
as
well
therapeutic
approaches
imaging
techniques
therapy.
In
addition,
current
application
future
challenges
opportunities
are
also
discussed.
RSC Advances,
Год журнала:
2024,
Номер
14(21), С. 14722 - 14741
Опубликована: Янв. 1, 2024
Manganese-based
nanomaterials
have
seen
rapid
development
in
chemodynamic
therapy
and
T
1
-enhanced
MRI
over
the
past
five
years,
holding
promising
prospects
various
combined
applications.
