Frontiers in Bioengineering and Biotechnology,
Год журнала:
2022,
Номер
10
Опубликована: Авг. 5, 2022
Bladder
cancer
is
one
of
the
concerning
urological
malignant
diseases
in
world,
which
has
a
clinical
need
for
effective
targeted
therapy.
The
development
nanotechnology-based
gene
delivery
to
bladder
tumor
sites
an
strategy
therapy
with
low/no
toxicity.
With
this
view,
present
work,
mesoporous
silica
nanoparticles
(MSNs)
modified
c(RGDfK)-PLGA-PEG
[c(RGDfK)-MSN
NPs]
were
constructed
co-delivery
miR-34a
and
siPD-L1
within
cells
tissues.
Our
findings
showed
that
downregulated
while
PD-L1
up-regulated
cell
lines
animal
studies.
This
nano-carrier
biocompatible
serum
environment
effectively
protects
against
degradation.
However,
we
c(RGDfK)-MSN
NPs
could
simultaneously
downregulate
expression
up-regulate
T24
mice
model
enhance
anti-tumor
effects
both
vivo
vitro
.
In
conclusion,
these
presented
new
suggestions
improving
therapeutic
strategies
specified
molecular
objectives
treatment.
ACS Nano,
Год журнала:
2022,
Номер
16(9), С. 15026 - 15041
Опубликована: Авг. 29, 2022
The
exciting
success
of
NBTXR3
in
the
clinic
has
triggered
a
tumult
activities
design
and
development
hafnium-based
nanoparticles.
However,
due
to
concerns
nondegradation
limited
functions,
biomedical
applications
Hf-based
nanoparticles
mainly
focus
on
tumors.
Herein,
tannic
acid
capped
hafnium
disulfide
(HfS2@TA)
nanosheets,
2D
atomic
crystal
materials
prepared
by
liquid-phase
exfoliation,
were
explored
as
high-performance
anti-inflammatory
nanoagents
for
targeted
therapy
inflammatory
bowel
disease
(IBD).
Benefiting
from
transformation
S2–/S6+
valence
state
huge
specific
surface
area,
obtained
HfS2@TA
nanosheets
not
only
capable
effectively
eliminating
reactive
oxygen
species/reactive
nitrogen
species
downregulating
pro-inflammatory
factors
but
also
could
be
excreted
via
kidney
hepatointestinal
systems.
Unexpectedly,
maintained
excellent
targeting
capability
an
inflamed
colon
even
harsh
digestive
tract
environment,
attributed
electrostatic
interactions
between
negatively
charged
positively
epithelium.
Encouragingly,
upon
oral
or
intravenous
administration,
quickly
inhibited
inflammation
repaired
intestinal
mucosa
barrier
both
dextran
sodium
sulfate
2,4,6-trinitrobenzenesulfonic
induced
IBD
models.
This
work
demonstrated
that
ultrathin
crystals
with
enhanced
accumulation
promising
IBD.
Molecules,
Год журнала:
2023,
Номер
28(6), С. 2733 - 2733
Опубликована: Март 17, 2023
Rhenium
(Re)
is
widely
used
in
the
diagnosis
and
treatment
of
cancer
due
to
its
unique
physical
chemical
properties.
Re
has
more
valence
electrons
outer
shell,
allowing
it
exist
a
variety
oxidation
states
form
different
geometric
configurations
with
many
ligands.
The
luminescence
properties,
lipophilicity,
cytotoxicity
complexes
can
be
adjusted
by
changing
ligand
Re.
This
article
mainly
reviews
development
radionuclide
188Re
radiotherapy
some
innovative
applications
as
well
therapeutic
approaches
imaging
techniques
therapy.
In
addition,
current
application
future
challenges
opportunities
are
also
discussed.
RSC Advances,
Год журнала:
2024,
Номер
14(21), С. 14722 - 14741
Опубликована: Янв. 1, 2024
Manganese-based
nanomaterials
have
seen
rapid
development
in
chemodynamic
therapy
and
T
1
-enhanced
MRI
over
the
past
five
years,
holding
promising
prospects
various
combined
applications.
