Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II

Journal of Controlled Release, Год журнала: 2023, Номер 362, С. 425 - 445

Опубликована: Сен. 8, 2023

Язык: Английский

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Benzobisthiadiazole-Based Small Molecular Near-Infrared-II Fluorophores: From Molecular Engineering to Nanophototheranostics

ACS Nano, Год журнала: 2024, Номер 18(6), С. 4683 - 4703

Опубликована: Янв. 31, 2024

Organic fluorescent molecules with emission in the second near-infrared (NIR-II) biological window have aroused increasing investigation cancer phototheranostics. Among these studies, Benzobisthiadiazole (BBT), high electron affinity, is widely utilized as acceptor constructing donor–acceptor–donor (D-A-D) structured fluorophores intensive (NIR) absorption and NIR-II fluorescence. Until now, numerous BBT-based dyes been employed tumor phototheranostics due to their exceptional structure tunability, biocompatibility, photophysical properties. This review systematically overviews research progress of small molecular focuses on molecule design bioapplications. First, engineering strategies fine-tune properties high-performance are discussed detail. Then, applications optical imaging phototherapy highlighted. Finally, current challenges future prospects also summarized. believed significantly promote further BBT-derived for

Язык: Английский

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Ultra-photostable small-molecule dyes facilitate near-infrared biophotonics

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Март 22, 2024

Abstract Long-wavelength, near-infrared small-molecule dyes are attractive in biophotonics. Conventionally, they rely on expanded aromatic structures for redshift, which comes at the cost of application performance such as photostability, cell permeability, and functionality. Here, we report a ground-state antiaromatic strategy showcase concise synthesis 14 cationic aminofluorene with mini (molecular weights: 299–504 Da) distinct spectra covering 700–1600 nm. Aminofluorene cell-permeable achieve rapid renal clearance via simple 44 Da carboxylation. This accelerates optical diagnostics injury by 50 min compared to existing macromolecular approaches. We develop compact molecular sensing platform vivo intracellular sensing, demonstrate versatile applications these multispectral fluorescence optoacoustic imaging. find that aromaticity reversal upon electronic excitation, indicated magnetic descriptors, not only reduces energy bandgap but also induces strong vibronic coupling, resulting ultrafast excited-state dynamics unparalleled photostability. These results support argument antiaromaticity useful design rule dye development, enabling performances essential modern

Язык: Английский

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Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes

Coordination Chemistry Reviews, Год журнала: 2024, Номер 514, С. 215907 - 215907

Опубликована: Май 12, 2024

Язык: Английский

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Nanosized Prussian blue and its analogs for bioimaging and cancer theranostics

Acta Biomaterialia, Год журнала: 2024, Номер 176, С. 77 - 98

Опубликована: Янв. 2, 2024

Язык: Английский

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Recent advances in the design of organic photothermal agents for cancer treatment: A review

Coordination Chemistry Reviews, Год журнала: 2024, Номер 506, С. 215719 - 215719

Опубликована: Фев. 24, 2024

Язык: Английский

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Recent advances and prospects of carbon dots in cancer nanotheranostics

Materials Chemistry Frontiers, Год журнала: 2019, Номер 4(2), С. 449 - 471

Опубликована: Дек. 16, 2019

This review summarizes and discusses the recent advances future prospects of carbon dots as nanotheranostic agents for anticancer applications.

Язык: Английский

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NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens

Biomaterials, Год журнала: 2020, Номер 259, С. 120315 - 120315

Опубликована: Авг. 15, 2020

Язык: Английский

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Activatable fluorescence sensors forin vivobio-detection in the second near-infrared window

Chemical Science, Год журнала: 2020, Номер 12(10), С. 3448 - 3459

Опубликована: Ноя. 12, 2020

Fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has exhibited advantages of high optical resolution at deeper penetration (ca. 5-20 mm) bio-tissues owing to reduced photon scattering, absorption and tissue autofluorescence. However, non-responsive "always on" sensors lack ability selective lesion areas, leading low signal-to-background ratio (SBR) poor sensitivity during bio-detection. In contrast, activatable show signal variation fluorescence intensity, spectral wavelength lifetime after responding micro-environment stimuli, detection reliability bio-sensing. This minireview summarizes design recently reported NIR-II sensors. Furthermore, challenges, opportunities prospects bio-sensing are also discussed.

Язык: Английский

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Multifunctional Prussian blue-based nanomaterials: Preparation, modification, and theranostic applications

Coordination Chemistry Reviews, Год журнала: 2020, Номер 419, С. 213393 - 213393

Опубликована: Июнь 8, 2020

Язык: Английский

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