Achieving
accurate
and
efficient
tumor
imaging
is
crucial
in
the
field
of
treatment,
as
it
facilitates
early
detection
precise
localization
tissues,
thereby
informing
therapeutic
strategies
surgical
interventions.
The
optical
technology
within
second
near-infrared
(NIR-II)
window
has
garnered
significant
interest
for
its
remarkable
benefits,
such
enhanced
tissue
penetration
depth,
superior
signal-to-background
ratio
(SBR),
minimal
autofluorescence,
reduced
photon
attenuation,
lower
scattering.
This
review
explained
design
optimization
nano-agents
responsive
to
NIR-II
window,
single-walled
carbon
nanotubes,
quantum
dots,
lanthanum-based
nanomaterials,
noble
metal
nanomaterials.
These
enable
non-invasive,
deep-tissue
with
high
spatial
resolution
their
properties
significantly
improve
accuracy,
efficiency,
versatility
imaging-guided
treatments.
And
we
discussed
characteristics
advantages
fluorescence
(FL)/photoacoustic
(PA)
providing
a
comprehensive
overview
latest
research
progress
different
FL/PA
therapy.
Furthermore,
exhaustively
reviewed
applications
multifunctional
nano-phototherapy
technologies
carried
out
by
light
including
photothermal
therapy
(PTT),
photodynamic
(PDT),
combined
modalities
like
photothermal-chemodynamic
(PTT-CDT),
photothermal-chemotherapy
(PTT-CT),
photothermal-
immunotherapy
(PTT-IO).
integrated
approaches
have
gradually
matured
over
past
decade
are
expected
become
safe
effective
non-invasive
treatment.
Finally,
outlined
prospects
challenges
development
innovation
diagnosis
nanoplatform.
aims
provide
insightful
perspectives
future
advancements
treatment
platforms.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
Abstract
The
precise
detection
of
multiple
microRNAs
(miRNAs)
is
great
significance
to
the
classification
various
cell
subtypes.
However,
miRNA
hindered
by
signal
leakage,
false‐positive
signals
and
low
expression
miRNAs.
Herein,
a
DNA
nanodevice
in
second
near
infrared
region
(NIR‐II,
1000‐1700
nm)
(DND‐II)
developed
for
dual
miRNAs
bioimaging
based
on
“AND”
logic‐gate
amplification
strategy.
spatiotemporally
controlled
logic‐gate‐based
DND‐II
fabricated
thermosensitive
liposomes
integrated
with
near‐infrared
probes.
In
particular,
“always‐on”
photoacoustic
probes
provided
an
additional
imaging
tool
monitor
distribution
vivo.
When
both
are
present,
generated
“turn
on”
fluorescent
through
logical
analysis
molecular
computation,
further
triggering
entropy‐driven
dual‐cycle
fluorescence
amplification.
spatiotemporal
provides
powerful
platform
early
diagnosis
photothermal
ablation
different
subtypes
tumor
cells.
Fluorescence
imaging,
a
highly
sensitive
molecular
imaging
modality,
is
being
increasingly
integrated
into
clinical
practice.
Imaging
within
the
second
near-infrared
biological
window
(NIR-II;
1,000
to
1,700
nm),
also
referred
as
shortwave
infrared,
has
received
substantial
attention
because
of
its
markedly
reduced
autofluorescence,
deeper
tissue
penetration,
and
enhanced
spatiotemporal
resolution
compared
traditional
(NIR)
imaging.
Indocyanine
green
(ICG),
US
Food
Drug
Administration-approved
NIR
fluorophore,
long
been
used
in
applications,
including
blood
vessel
angiography,
vascular
perfusion
monitoring,
tumor
detection.
Recent
advancements
NIR-II
technology
have
revitalized
interest
ICG,
revealing
extended
tail
fluorescence
beyond
nm
reaffirming
potential
clinically
translatable
fluorophore
for
vivo
theranostic
applications
diagnosing
various
diseases.
This
review
emphasizes
notable
advances
use
ICG
derivatives
image-guided
therapy
from
both
fundamental
perspectives.
We
provide
concise
conclusion
discuss
challenges
future
opportunities
with
using
approved
fluorophores.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
Nanoprobes
with
NIR-II
fluorescence
and
a
large
Stokes
shift
are
highly
desirable
for
high-quality
bioimaging
applications.
However,
designing
fluorescent
nanoprobes
the
desired
photophysical
properties
based
on
small
organic
molecules
remains
significant
challenge.
Herein,
we
report
naphthalimide
(NMI)-based
molecule,
NMI-BF2,
by
further
enhancing
electron
affinity
of
NMI
through
incorporation
boron
difluoride
formazanate.
NMI-BF2
exhibits
sufficient
quantum
yield
(QY)
0.53%,
263
nm,
excellent
photostability.
For
biological
applications,
is
coassembled
fetal
bovine
serum
(FBS)
to
prepare
biocompatible
nanoprobe,
NMI-BF2/FBS,
which
maintains
good
QY
0.21%
photothermal
conversion
efficiency
32.5%.
In
vitro
in
vivo
studies
verified
that
NMI-BF2/FBS
nanoprobe
shows
an
antitumor
therapeutic
effect,
guided
photoacoustic
imaging.
