Biocatalysis: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(1), С. 88 - 119

Опубликована: Июнь 18, 2020

Abstract Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes organic synthesis, especially make chiral compounds for pharmaceuticals well the flavors and fragrance industry, are most prominent examples. In addition, biocatalysts used on a large scale specialty even bulk chemicals. This review intends give illustrative examples this field with special focus scalable production using enzymes. It also discusses opportunities limitations enzymatic syntheses distinct provides outlook emerging enzyme classes.

Язык: Английский

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Biocatalysis

Nature Reviews Methods Primers, Год журнала: 2021, Номер 1(1)

Опубликована: Июнь 24, 2021

Язык: Английский

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Power of Biocatalysis for Organic Synthesis

ACS Central Science, Год журнала: 2021, Номер 7(1), С. 55 - 71

Опубликована: Янв. 14, 2021

Biocatalysis, using defined enzymes for organic transformations, has become a common tool in synthesis, which is also frequently applied industry. The generally high activity and outstanding stereo-, regio-, chemoselectivity observed many biotransformations are the result of precise control reaction active site biocatalyst. This achieved by exact positioning reagents relative to each other fine-tuned 3D environment, specific activating interactions between protein, subtle movements catalyst. Enzyme engineering enables one adapt catalyst desired process. A well-filled biocatalytic toolbox ready be used various reactions. Providing nonnatural conditions evolving biocatalysts play with myriad options creating novel transformations thereby opening new, short pathways target molecules. Combining several pot perform reactions concurrently increases efficiency biocatalysis even further.

Язык: Английский

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New frontiers in enzyme immobilisation: robust biocatalysts for a circular bio-based economy

Chemical Society Reviews, Год журнала: 2021, Номер 50(10), С. 5850 - 5862

Опубликована: Янв. 1, 2021

This tutorial review focuses on recent advances in technologies for enzyme immobilisation, enabling their cost-effective use the bio-based economy and continuous processing general.

Язык: Английский

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Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates

Nature Chemistry, Год журнала: 2020, Номер 12(11), С. 990 - 1004

Опубликована: Окт. 19, 2020

Язык: Английский

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Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

Chemical Reviews, Год журнала: 2021, Номер 122(1), С. 1052 - 1126

Опубликована: Ноя. 30, 2021

Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool the synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic processes launched in half last century exploited whole-cell microorganisms where specific enzyme at work was not known. In meantime, novel molecular biology methods, such efficient gene sequencing and triggered breakthroughs directed evolution rapid development process-stable with broad substrate scope good selectivities tailored substrates. To date, are employed to enable shorter, more efficient, sustainable alternative routes toward (established) small molecule APIs, additionally used perform standard reactions API efficiently. Herein, large-scale synthetic containing key steps >130 APIs approved drugs drug candidates compared corresponding chemical protocols (if available) regarding steps, reaction conditions, scale. review is structured according functional group formed reaction.

Язык: Английский

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The E factor at 30: a passion for pollution prevention

Green Chemistry, Год журнала: 2023, Номер 25(5), С. 1704 - 1728

Опубликована: Янв. 1, 2023

Publication of the E Factor drew attention to problem waste in chemicals manufacture. Thirty yeas later it is abundantly clear that underlying cause global environmental problems, from climate change plastic pollution.

Язык: Английский

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Enzymatic Conversion of CO₂: From Natural to Artificial Utilization

Chemical Reviews, Год журнала: 2023, Номер 123(9), С. 5702 - 5754

Опубликована: Янв. 24, 2023

Enzymatic carbon dioxide fixation is one of the most important metabolic reactions as it allows capture inorganic from atmosphere and its conversion into organic biomass. However, due to often unfavorable thermodynamics difficulties associated with utilization CO

Язык: Английский

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Combining chemistry and protein engineering for new-to-nature biocatalysis

Nature Synthesis, Год журнала: 2022, Номер 1(1), С. 18 - 23

Опубликована: Янв. 12, 2022

Язык: Английский

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Photochemical and Electrochemical Strategies towards Benzylic C−H Functionalization: A Recent Update

Advanced Synthesis & Catalysis, Год журнала: 2021, Номер 363(7), С. 1810 - 1834

Опубликована: Фев. 16, 2021

Abstract Transition metal‐catalysed processes have been widely used for the functionalization of inert C−H bonds. Strategies benzylic position having a relatively weak bond (bond dissociation energy∼ 80–90 kcal/mol) differ from aliphatic and aromatic positions with stronger The recent advances in direct activation through generation C( sp 3 ) radicals demonstrated potential electrochemistry photochemistry as means constructing new chemical This review will cover progress organic radical strategies employing sustainable tools. In addition, mechanistic details typical reactions included which, turn, help researchers to look at this promising area different perspective towards discoveries often hidden opportunities. magnified image

Язык: Английский

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