Biomaterials Science, Год журнала: 2020, Номер 8(9), С. 2404 - 2419
Опубликована: Янв. 1, 2020
First report on the effect of topology design biodegradation, mechanical properties, and cell responses additively manufactured Zn.
Язык: Английский
Materials & Design, Год журнала: 2021, Номер 200, С. 109448 - 109448
Опубликована: Янв. 8, 2021
Additively manufactured porous NiTi alloys hold unprecedented promise in metallic implants due to their low elastic modulus and superelastic behavior. Such structures are usually topologically ordered designed with periodically-repeating unit cells. However, the behaviors of fractal have never been studied. The Menger sponge-like consisting non-periodic pores mimick architectures biomechanical properties human bone. In this investigation, sponges were fabricated by additive manufacturing using selective laser melting technology, systematically characterized for first time. bulk exhibit fully recoverable responses slim stress hysteresis. mechanical match cortical bones. display excellent recovery strain ratios even at high porosity levels. highly fractalized almost identical cancellous deformation mechanism undergoes a transformation from bending-dominated stretching-dominated mode when fractalized. unique combination topology, nanostructured microstructure, controllable large make sponge promising candidate implants.
Язык: Английский
Процитировано
78
Additive manufacturing, Год журнала: 2019, Номер 32, С. 100991 - 100991
Опубликована: Дек. 9, 2019
Additive manufacturing has facilitated fabrication of complex and patient-specific metallic meta-biomaterials that offer an unprecedented collection mechanical, mass transport, biological properties as well a fully interconnected porous structure. However, applying for addressing unmet clinical needs in orthopedic surgery requires additional surface functionalities should be induced through tailor-made coatings. Here, we developed multi-functional layer-by-layer coatings to simultaneously prevent implant-associated infections stimulate bone tissue regeneration. We applied multiple layers gelatin- chitosan-based containing either morphogenetic protein (BMP)-2 or vancomycin on the selective laser melted structures made from commercial pure Titanium (CP Ti) designed using triply periodic minimal (i.e., sheet gyroid). The additive process resulted structure met design values comparatively. X-ray photoelectron spectroscopy spectra confirmed presence composition coating layers. release profiles showed continued both BMP-2 2–3 weeks. Furthermore, exhibited very strong antibacterial behavior with up 8 orders magnitude reduction planktonic implant-adherent bacteria no signs biofilm formation. osteogenic differentiation mesenchymal stem cells was enhanced, shown by two-fold increase alkaline phosphatase activity four-fold mineralization all experimental groups BMP-2. Eight-week subcutaneous implantation vivo foreign body response, while connective ingrowth promoted coating. These results unequivocally confirm superior performance biomaterials.
Язык: Английский
Процитировано
77
Additive manufacturing, Год журнала: 2020, Номер 34, С. 101246 - 101246
Опубликована: Май 11, 2020
Язык: Английский
Процитировано
76
ACS Applied Materials & Interfaces, Год журнала: 2021, Номер 13(19), С. 22110 - 22123
Опубликована: Май 4, 2021
Laser additive manufacturing has led to a paradigm shift in the design of next-generation customized porous implants aiming integrate better with surrounding bone. However, conflicting criteria have limited development fully functional implants; increasing porosity improves body fluid/cell-laden prepolymer permeability at expense compromising mechanical stability. Here, functionally gradient and scaffolds designed based on interconnected triply periodic minimal surfaces (TPMS) are demonstrated. High local is defined implant/tissue interface improve biological response. Gradually decreasing from surface center constructs provides strength selective laser melted Ti–6Al–4V implants. The effect unit cell size studied discover printability limit where specific area maximized. Furthermore, studies topology effects suggest that bending-dominated architectures can provide significantly enhanced deformability, compared stretching-dominated architectures. A finite element (FE) model developed also showed great predictability (within ∼13%) responses physical activities. Finally, vitro biocompatibility were conducted for two-dimensional (2D) three-dimensional (3D) cases. results 2D conjunction roughness show favored attachment implant surface. Also, 3D study incorporated cell-laden gelatin methacryloyl (GelMA) hydrogel excellent viability. procedure proposed here new insights into hip simultaneous high responses.
Язык: Английский
Процитировано
75
Biomaterials Science, Год журнала: 2020, Номер 8(9), С. 2404 - 2419
Опубликована: Янв. 1, 2020
First report on the effect of topology design biodegradation, mechanical properties, and cell responses additively manufactured Zn.
Язык: Английский
Процитировано
72