Smart nanoparticles for cancer therapy

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Ноя. 3, 2023

Abstract Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer treatment. The field of oncology, nanotechnology, and biomedicine has witnessed rapid progress, leading innovative developments in smart nanoparticles safer more effective therapy. In this review, we will highlight recent advancements including polymeric dendrimers, micelles, liposomes, protein cell membrane mesoporous silica gold iron oxide quantum dots, carbon nanotubes, black phosphorus, MOF others. We focus on their classification, structures, synthesis, intelligent features. These possess the ability various external internal stimuli, such enzymes, pH, temperature, optics, magnetism, making them systems. Additionally, review explore latest studies tumor targeting functionalizing surfaces with tumor-specific ligands like antibodies, peptides, transferrin, folic acid. also summarize different types options, small molecules, proteins, nucleic acids, even living cells, potential use While is promising, acknowledge challenges clinical prospects associated use. Finally, propose blueprint that involves artificial intelligence-powered treatment applications. By harnessing aims usher new era personalized therapy, providing patients individualized options.

Язык: Английский

---

Advances in metal–organic framework-based nanozymes and their applications

Coordination Chemistry Reviews, Год журнала: 2021, Номер 449, С. 214216 - 214216

Опубликована: Сен. 15, 2021

Язык: Английский

---

Metalated covalent organic frameworks: from synthetic strategies to diverse applications

Chemical Society Reviews, Год журнала: 2022, Номер 51(15), С. 6307 - 6416

Опубликована: Янв. 1, 2022

This review highlights the recent advances of metalated covalent organic frameworks, including synthetic strategies and applications, discusses current challenges future directions.

Язык: Английский

---

Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry

Chemical Science, Год журнала: 2021, Номер 13(4), С. 863 - 889

Опубликована: Ноя. 29, 2021

Applying Fenton chemistry in the tumor microenvironment (TME) for cancer therapy is most significant feature of chemodynamic (CDT). Owing to mild acid and overexpressed H2O2 TME, more cytotoxic hydroxyl radicals (˙OH) are generated cells via Fenton-like reactions. Without external stimulus drug resistance generation, reactive oxygen species (ROS)-mediated CDT exhibits a specific desirable anticancer effect has been seen as promising strategy therapy. However, optimizing treatment efficiency TME still challenging because limited catalytic agents strong antioxidant capacity TME. Hence, scientists trying their best design fabricate many with excellent activity remodeling optimal CDT. In this perspective, latest progress discussed, some representative examples presented. Consequently, strategies further guided by provided. Most importantly, several feasible ways developing future offered reference.

Язык: Английский

---

Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

Nano-Micro Letters, Год журнала: 2022, Номер 14(1)

Опубликована: Апрель 6, 2022

Abstract Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, low yield, making them difficult to be broadly applicable. As an emerging type artificial enzyme, nanozymes that combine the characteristics nanomaterials are promising alternatives. On one hand, have enzyme-like catalytic activities regulate biochemical reactions. other also inherit properties nanomaterials, which can ameliorate shortcomings natural serve as versatile platforms for diverse applications. In this review, various mimic activity different introduced. The achievements in cancer diagnosis treatment technologies summarized by highlighting advantages these Finally, future research directions rapidly developing field outlooked."Image missing"

Язык: Английский

---

Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy

Theranostics, Год журнала: 2022, Номер 13(1), С. 295 - 323

Опубликована: Дек. 19, 2022

Cancer remains a severe threat to human health. To date, although various therapeutic methods, including radiotherapy (RT), chemotherapy, chemodynamic therapy (CDT), phototherapy, starvation therapy, and immunotherapy, have entered new stage of rapid progress in cancer theranostics, their limited effect significant side effects need be considered carefully. With the development nanotechnology, marriage nanomaterials methods provides practical possibility improve deficiencies therapy. Notably, metal-organic frameworks (MOFs) composed ions/clusters bridging ligands through coordination bonds been widely applied deal with drawbacks different such as effects, low stability, poor efficacy, owing controllable morphologies, tailorable diameters, diverse compositions, tunable porosities, high specific surface areas, facile functionalization, good biocompatibility. This review summarizes recent advanced developments achievements multifunctional MOF-based nanoplatforms for single RT, CDT, phototherapy (photodynamic photothermal therapy), combination methods. Moreover, prospects challenges used tumor are also discussed.

Язык: Английский

---

Future‐Oriented Advanced Diarylethene Photoswitches: From Molecular Design to Spontaneous Assembly Systems

Advanced Materials, Год журнала: 2021, Номер 34(16)

Опубликована: Дек. 6, 2021

Diarylethene (DAE) photoswitch is a new and promising family of photochromic molecules has shown superior performance as smart trigger in stimulus-responsive materials. During the past few decades, DAE achieved leap from simple to functional developed toward validity universal switching building block. In recent years, introduction into an assembly system been attractive strategy that enables behavior blocks be manifested at level entire system, beyond unit itself. This assembly-based will bring many unexpected results promote design manufacture generation advanced Here, advances fabrication diarylethene materials science, chemistry, biomedicine are reviewed.

Язык: Английский

---

Recent development of metal-organic framework nanocomposites for biomedical applications

Biomaterials, Год журнала: 2021, Номер 281, С. 121322 - 121322

Опубликована: Дек. 15, 2021

Язык: Английский

---

Porphyrin-Containing MOFs and COFs as Heterogeneous Photosensitizers for Singlet Oxygen-Based Antimicrobial Nanodevices

ACS Applied Materials & Interfaces, Год журнала: 2021, Номер 13(23), С. 26651 - 26672

Опубликована: Июнь 4, 2021

Visible-light irradiation of porphyrin and metalloporphyrin dyes in the presence molecular oxygen can result photocatalytic generation singlet (1O2). This type II reactive species (ROS) finds many applications where dye, also called photosensitizer, is dissolved (i.e., homogeneous phase) along with substrate to be oxidized. In contrast, metal-organic frameworks (MOFs) are insoluble (or will disassemble) when placed a solvent. When stable as suspension, MOFs adsorb large amount O2 photocatalytically generate 1O2 heterogeneous process efficiently. Considering immense surface area great capacity for gas adsorption MOFs, they seem ideal candidates this application. Very recently, covalent-organic (COFs), variants reticulation relies on covalent rather than coordination bonds, have emerged efficient photosensitizers. comprehensive mini review describes recent developments use porphyrin-based or porphyrin-containing COFs, including nanosized versions, photosensitizers toward antimicrobial applications.

Язык: Английский

---

MOF-derived CuS@Cu-MOF nanocomposites for synergistic photothermal-chemodynamic-chemo therapy

Chemical Engineering Journal, Год журнала: 2022, Номер 441, С. 135964 - 135964

Опубликована: Март 23, 2022

Язык: Английский

---