Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(12), С. 5214 - 5225
Опубликована: Март 15, 2022
Achieving
convergent
synthetic
strategies
has
long
been
a
gold
standard
in
constructing
complex
molecular
skeletons,
allowing
for
the
rapid
generation
of
complexity
comparatively
streamlined
routes.
Traditionally,
biocatalysis
not
played
prominent
role
laboratory
synthesis,
with
application
biocatalysts
primarily
limited
to
synthesis
chiral
fragments.
Although
use
enzymes
enable
approaches
is
relatively
new
and
emerging,
combining
efficiency
transformations
selectivity
achievable
through
creates
opportunities
efficient
strategies.
This
Perspective
provides
an
overview
recent
developments
biocatalytic
offers
insights
into
advantages
these
methods
compared
their
small
molecule-based
counterparts.
ACS Central Science,
Год журнала:
2021,
Номер
7(1), С. 55 - 71
Опубликована: Янв. 14, 2021
Biocatalysis,
using
defined
enzymes
for
organic
transformations,
has
become
a
common
tool
in
synthesis,
which
is
also
frequently
applied
industry.
The
generally
high
activity
and
outstanding
stereo-,
regio-,
chemoselectivity
observed
many
biotransformations
are
the
result
of
precise
control
reaction
active
site
biocatalyst.
This
achieved
by
exact
positioning
reagents
relative
to
each
other
fine-tuned
3D
environment,
specific
activating
interactions
between
protein,
subtle
movements
catalyst.
Enzyme
engineering
enables
one
adapt
catalyst
desired
process.
A
well-filled
biocatalytic
toolbox
ready
be
used
various
reactions.
Providing
nonnatural
conditions
evolving
biocatalysts
play
with
myriad
options
creating
novel
transformations
thereby
opening
new,
short
pathways
target
molecules.
Combining
several
pot
perform
reactions
concurrently
increases
efficiency
biocatalysis
even
further.
Chemical Reviews,
Год журнала:
2021,
Номер
122(1), С. 1052 - 1126
Опубликована: Ноя. 30, 2021
Biocatalysis,
using
enzymes
for
organic
synthesis,
has
emerged
as
powerful
tool
the
synthesis
of
active
pharmaceutical
ingredients
(APIs).
The
first
industrial
biocatalytic
processes
launched
in
half
last
century
exploited
whole-cell
microorganisms
where
specific
enzyme
at
work
was
not
known.
In
meantime,
novel
molecular
biology
methods,
such
efficient
gene
sequencing
and
triggered
breakthroughs
directed
evolution
rapid
development
process-stable
with
broad
substrate
scope
good
selectivities
tailored
substrates.
To
date,
are
employed
to
enable
shorter,
more
efficient,
sustainable
alternative
routes
toward
(established)
small
molecule
APIs,
additionally
used
perform
standard
reactions
API
efficiently.
Herein,
large-scale
synthetic
containing
key
steps
>130
APIs
approved
drugs
drug
candidates
compared
corresponding
chemical
protocols
(if
available)
regarding
steps,
reaction
conditions,
scale.
review
is
structured
according
functional
group
formed
reaction.
Chemical Society Reviews,
Год журнала:
2021,
Номер
51(2), С. 594 - 627
Опубликована: Дек. 20, 2021
The
many
waves
of
biocatalysis
have
arisen
to
solve
long-standing
synthetic
challenges.
From
industrially
applied
hydrolases
enzymes
catalysing
selective
C–C-bond
formation,
enables
new
tools
access
a
plethora
compounds.
Chemical Reviews,
Год журнала:
2023,
Номер
123(19), С. 11269 - 11335
Опубликована: Сен. 26, 2023
Late-stage
functionalization
(LSF)
constitutes
a
powerful
strategy
for
the
assembly
or
diversification
of
novel
molecular
entities
with
improved
physicochemical
biological
activities.
LSF
can
thus
greatly
accelerate
development
medicinally
relevant
compounds,
crop
protecting
agents,
and
functional
materials.
Electrochemical
synthesis
has
emerged
as
an
environmentally
friendly
platform
transformation
organic
compounds.
Over
past
decade,
electrochemical
late-stage
(eLSF)
gained
major
momentum,
which
is
summarized
herein
up
to
February
2023.
Science,
Год журнала:
2021,
Номер
372(6549), С. 1452 - 1457
Опубликована: Июнь 24, 2021
Easing
oxygen
into
arenes
Although
is
all
around
us,
it
often
surprisingly
difficult
to
use
for
selective
chemical
oxidations,
necessitating
more
expensive,
wasteful
alternatives.
Li
et
al.
report
that
careful
ligand
optimization
produces
palladium
catalysts
can
efficiently
activate
hydroxylate
a
variety
of
aryl
and
heteroaromatic
rings
adjacent
carboxylic
acid
substituent.
The
binds
through
pyridine
pyridone
components,
the
authors
posit
tautomerization
between
dative
anionic
coordination
modes
plays
role
in
its
effectiveness.
Science
,
abg2362,
this
issue
p.
1452
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Янв. 20, 2021
Abstract
Recently,
with
the
boosted
development
of
radical
chemistry,
enantioselective
functionalization
C(
sp
3
)–H
bonds
via
a
pathway
has
witnessed
renaissance.
In
principle,
two
distinct
catalytic
modes,
distinguished
by
steps
in
which
stereochemistry
is
determined
(the
formation
step
or
step),
can
be
devised.
This
Perspective
discusses
state-of-the-art
area
involving
intermediates
as
well
future
challenges
and
opportunities.
ACS Central Science,
Год журнала:
2021,
Номер
7(7), С. 1105 - 1116
Опубликована: Июнь 25, 2021
The
use
of
enzyme-mediated
reactions
has
transcended
ancient
food
production
to
the
laboratory
synthesis
complex
molecules.
This
evolution
been
accelerated
by
developments
in
sequencing
and
DNA
technology,
bioinformatic
protein
engineering
tools,
increasingly
interdisciplinary
nature
scientific
research.
Biocatalysis
become
an
indispensable
tool
applied
academic
industrial
spheres,
enabling
synthetic
strategies
that
leverage
exquisite
selectivity
enzymes
access
target
In
this
Outlook,
we
outline
technological
advances
have
led
field's
current
state.
Integration
biocatalysis
into
mainstream
chemistry
hinges
on
increased
well-characterized
permeation
retrosynthetic
logic.
Ultimately,
anticipate
is
poised
enable
molecules
at
new
levels
efficiency
throughput.
