Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT

ACS Nano, Год журнала: 2022, Номер 16(3), С. 4162 - 4174

Опубликована: Март 1, 2022

Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy (PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy acceptor planarization and donor rotation proposed to design I photosensitizers (PSs) photothermal reagents. Acceptor can not only enforce intramolecular charge transfer redshift NIR absorption but also PSs from photochemical pathways. Donor optimizes conversion efficiency (PCE). Accordingly, three 3,6-divinyl-substituted diketopyrrolopyrrole (DPP) derivatives, 2TPAVDPP, TPATPEVDPP, 2TPEVDPP, with different number rotors were prepared. Experimental results showed that compounds excellent PSs, corresponding 2TPEVDPP nanoparticles (NPs) most possessed highest PCE. The photophysical properties NPs are particularly suitable for in vivo fluorescence imaging-guided synergistic PDT/PTT therapy. helpful exploiting phototherapeutic reagents high efficacy PDT PTT.

Язык: Английский

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Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Год журнала: 2023, Номер 17(15), С. 14347 - 14405

Опубликована: Июль 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Язык: Английский

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Photodecaging of a Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(9), С. 4091 - 4101

Опубликована: Фев. 16, 2022

Despite the clinical success of photodynamic therapy (PDT), application this medical technique is intrinsically limited by low oxygen concentrations found in cancer tumors, hampering production therapeutically necessary singlet (1O2). To overcome limitation, we report on a novel mitochondria-localized iridium(III) endoperoxide prodrug (2-O-IrAn), which, upon two-photon irradiation NIR, synergistically releases highly cytotoxic complex (2-IrAn), oxygen, and an alkoxy radical. 2-O-IrAn was to be (photo-)toxic hypoxic tumor cells multicellular spheroids (MCTS) nanomolar range. provide selectivity improve pharmacological properties 2-O-IrAn, it encapsulated into biotin-functionalized polymer. The generated nanoparticles were nearly fully eradicate inside mouse model within single treatment. This study presents, best our knowledge, first example iridium(III)-based for synergistic therapy/photoactivated chemotherapy, opening up new avenues treatment tumors.

Язык: Английский

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Recent advances in the design of afterglow materials: mechanisms, structural regulation strategies and applications

Chemical Society Reviews, Год журнала: 2023, Номер 52(22), С. 8005 - 8058

Опубликована: Янв. 1, 2023

Afterglow materials have attracted widespread attention owing to their distinctive and long-lived optical emission properties which create exciting opportunities in various fields.

Язык: Английский

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Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

Chemical Reviews, Год журнала: 2022, Номер 122(6), С. 6850 - 6918

Опубликована: Март 2, 2022

Photoacoustic (PA) imaging technology, a three-dimensional hybrid modality that integrates the advantage of optical and acoustic imaging, has great application prospects in molecular due to its high depth resolution. To endow PA with ability for real-time visualization precise biomedical diagnosis, numerous activatable probes which can specifically alter their intensities upon reacting targets or biological events interest have been developed. This review highlights recent developments applications including detection biotargets events. First, generation mechanism signals will be given, followed by brief introduction contrast agents used probe design. Then we particularly summarize general design principles alteration strategies developing probes. Furthermore, give detailed discussion living systems. At last, current challenges outlooks future discussed. We hope this stimulate new ideas explore potentials future.

Язык: Английский

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Multimodal Imaging‐Guided Photothermal Immunotherapy Based on a Versatile NIR‐II Aggregation‐Induced Emission Luminogen

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(27)

Опубликована: Март 28, 2022

Abstract Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed prepared based on benzo[ c ]thiophene unit as building block; it can be used for simultaneous fluorescence imaging (FLI) in second near‐infrared (NIR‐II) window, photoacoustic (PAI), (PTI), thermal eradication of Further experiments validate that therapy (PTT) mediated by TPA‐BT‐DPTQ nanoparticles not only destroys primary tumor but also enhances immunogenicity further suppressing growth at distant sites. Furthermore, PTT combining programmed death‐ligand 1 (PD‐L1) antibody prevents metastasis recurrence cancer potentiating effect immunotherapy.

Язык: Английский

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Aggregation behaviour of pyrene-based luminescent materials, from molecular design and optical properties to application

Chemical Society Reviews, Год журнала: 2023, Номер 52(19), С. 6715 - 6753

Опубликована: Янв. 1, 2023

This review not only highlights the progress of emission and electronic behaviour new pyrene-based luminescence molecules in aggregated state, but also provides a perspective for understanding mechanism optoelectronic properties pyrenes.

Язык: Английский

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An Approach to Developing Cyanines with Simultaneous Intersystem Crossing Enhancement and Excited-State Lifetime Elongation for Photodynamic Antitumor Metastasis

Journal of the American Chemical Society, Год журнала: 2021, Номер 143(31), С. 12345 - 12354

Опубликована: Июль 29, 2021

Heavy-atom-based photosensitizers usually exhibit shortened triplet-state lifetimes, which is not ideal for hypoxic tumor photodynamic therapy. Although several heavy-atom-free possess long the clinical applicability limited by their short excitation wavelengths, poor photon capture abilities, and intrinsically hydrophobic structures. Herein we developed a novel NIR photosensitizer design strategy introducing sterically bulky electron-rich moieties at meso position of pentamethine cyanine (Cy5) skeleton, simultaneously enhanced intersystem crossing (ISC) prolonged excited-state lifetime. We found that 1O2 generation ability directly correlated to electron-donating substituent in cyanine, lifetime was much elongated when substituents were anthracene derivatives substituted 9-position. Our star compound, ANOMe-Cy5, exhibits intense absorption, highest quantum yield (4.48-fold higher than Cy5), longest (9.80-fold longer lossless emission intensity (nearly no change compared with Cy5). Such excellent photophysical properties coupled its inherently cationic hydrophilic nature enable realize photoablation solid antitumor lung metastasis. This study highlights new imaging-guided cancer treatment.

Язык: Английский

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Organic dye assemblies with aggregation‐induced photophysical changes and their bio‐applications

Aggregate, Год журнала: 2021, Номер 2(4)

Опубликована: Фев. 23, 2021

Abstract Phototheranostics provide a safe, effective, and noninvasive way for the diagnosis treatment of contemporary diseases, organic dyes play vital role. For example, chemical modification endowed with powerful reactive oxygen species or heat generation ability, favoring photodynamic therapy photoacoustic (PA) imaging guided photothermal (PTT) serious diseases. Therefore, photophysical properties manipulation has become focus in current dye chemistry research. The development aggregate science made great effort to solve this problem. In recent years, large number studies have focused on molecular aggregation behavior its effect performance. most famous example is discovery aggregation‐induced emission (AIE) phenomenon. Based AIE theory, more theories revealing relationship between were proposed elucidated. property changes caused by unique discipline, guiding material science. With help self‐assembly, controllable can be realized, stable nano‐theranostic reagents obtained. Furthermore, constructing assemblies various will greatly reduce cost theranostic reagents, thus, expanding biomedical applications dyes. review focuses characteristic their biological including, fluorescence/phosphorescence/PA as well PTT. This guidance design dyes, methods, construction multifunctional phototheranostic reagents.

Язык: Английский

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Rational Design of High Brightness NIR-II Organic Dyes with S-D-A-D-S Structure

Accounts of Materials Research, Год журнала: 2021, Номер 2(3), С. 170 - 183

Опубликована: Фев. 2, 2021

ConspectusFluorescence bioimaging in the second near-infrared window (NIR-II, 1000–1700 nm) is a superior visualization tool with deeper penetration and higher spatial resolution than traditional vis/NIR (400–1000 nm). Developing desirable NIR-II agents high brightness (high quantum yield (QY) absorption coefficient), longer emission wavelengths, light stability, good biocompatibility bottleneck that must be crossed process of clinical transformation. organic attract more attention because their biocompatibility. Researchers are committed to develop small molecules an adjustable narrow band gap emit wavelengths. However, reduced molecular fluorophores generally triggered interactions between conjugated skeleton other molecules, leading decreased fluorescence QY, especially quenching aqueous systems.Aiming enhance fluorophores' systems, engineering shielding donor unit introduced fluorophores, these composed unit, donor(s), acceptor, (S-D-A-D-S) structure. We found donor's steric hindrance brings about twist can tuned electrostatic potential surfaces hydrophobic effects, which reduce water approaching excitation center. In addition protective effect electron units, changes weakened by fluorophore beneficial stability excited states for maintained water-soluble environments. torsion will intramolecular charge transfer (ICT), transition from ground state (S0–S1), undesired decrease coefficient. Thus, it necessary improve QY without sacrificing Therefore, bright need have rational balanced backbone distortion strengthen ICT better protect molecule effect, resulting improvements coefficient simultaneously.In this Account, we present concise summary analysis design S-D-A-D-S structural tunable enhanced coefficients based on strategy. expect Account trigger research interest explore inspiring performance employ them promote

Язык: Английский

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