Antimicrobial peptides for combating drug-resistant bacterial infections

Drug Resistance Updates, Год журнала: 2023, Номер 68, С. 100954 - 100954

Опубликована: Март 1, 2023

The problem of drug resistance due to long-term use antibiotics has been a concern for years. As this grows worse, infections caused by multiple bacteria are expanding rapidly and extremely detrimental human health. Antimicrobial peptides (AMPs) good alternative current antimicrobials with potent antimicrobial activity unique mechanisms, which have advantages over traditional in fighting against drug-resistant bacterial infections. Currently, researchers conducted clinical investigations on AMPs while integrating new technologies the development AMPs, such as changing amino acid structure using different delivery methods AMPs. This article introduces basic properties deliberates mechanism therapeutic disadvantages advances combating also discussed. provides important insights into research application

Язык: Английский

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Antimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications

Antibiotics, Год журнала: 2022, Номер 11(10), С. 1417 - 1417

Опубликована: Окт. 16, 2022

The growing emergence of antimicrobial resistance represents a global problem that not only influences healthcare systems but also has grave implications for political and economic processes. As the discovery novel agents is lagging, one solutions innovative therapeutic options would expand our armamentarium against this hazard. Compounds interest in many such studies are peptides (AMPs), which actually represent host’s first line defense pathogens involved innate immunity. They have broad range activity Gram-negative Gram-positive bacteria, fungi, viruses, with specific mechanisms action utilized by different AMPs. Coupled lower propensity development, it becoming clear AMPs can be seen as emerging very promising candidates more pervasive usage treatment infectious diseases. However, their use quotidian clinical practice without challenges. In review, we aimed to summarize state-of-the-art evidence on structure AMPs, well provide detailed information activity. We present contemporary trials application highlight beyond diseases potential challenges may arise increasing availability.

Язык: Английский

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Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies

Chemical Science, Год журнала: 2021, Номер 13(2), С. 345 - 364

Опубликована: Дек. 16, 2021

This review surveys the structure–activity of advanced antimicrobial cationic polymers with low toxicity and high selectivity. Their uses as potentiating adjuvants antibiofilm agents are also covered.

Язык: Английский

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Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice

Burns & Trauma, Год журнала: 2022, Номер 10

Опубликована: Янв. 1, 2022

Abstract Acute and chronic wound infection has become a major worldwide healthcare burden leading to significantly high morbidity mortality. The underlying mechanism of infections been widely investigated by scientist, while standard management is routinely used in general practice. However, strategies for the diagnosis treatment remain great challenge due occurrence biofilm colonization, delayed healing drug resistance. In present review, we summarize common microorganisms found acute discuss challenges from aspects clinical diagnosis, non-surgical methods surgical methods. Moreover, highlight emerging innovations development antimicrobial peptides, phages, controlled delivery, dressing materials herbal medicine, find that sensitive diagnostics, combined skin microbiome regulation could be future directions infection.

Язык: Английский

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Antimicrobial peptide-based materials: opportunities and challenges

Journal of Materials Chemistry B, Год журнала: 2022, Номер 10(14), С. 2384 - 2429

Опубликована: Янв. 1, 2022

The design of antimicrobial peptide-based materials for biomedical applications such as fighting infections in various organs, cancer therapy, gene delivery and detection bacteria.

Язык: Английский

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Modern venomics—Current insights, novel methods, and future perspectives in biological and applied animal venom research

GigaScience, Год журнала: 2022, Номер 11

Опубликована: Янв. 1, 2022

Abstract Venoms have evolved >100 times in all major animal groups, and their components, known as toxins, been fine-tuned over millions of years into highly effective biochemical weapons. There are many outstanding questions on the evolution toxin arsenals, such how venom genes originate, contributes to fitness venomous species, which modifications at genomic, transcriptomic, protein level drive evolution. These received particularly little attention outside snakes, cone snails, spiders, scorpions. Venom compounds further become a source inspiration for translational research using diverse bioactivities various applications. We highlight here recent advances new strategies modern venomics discuss technological innovations multi-omic methods dramatically improve animals. The study genomes through CRISPR knockdown technologies will increase our understanding toxins evolve functions they different ontogenetic stages during development Mass spectrometry imaging combined with spatial transcriptomics, situ hybridization techniques, computer tomography gives us insights distribution system function apparatus. All these evolutionary biological contribute more efficiently identify compounds, can then be synthesized or produced adapted expression systems test bioactivity. Finally, we critically agrochemical, pharmaceutical, therapeutic, diagnostic (so-called translational) aspects venoms from humans benefit.

Язык: Английский

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Multitalented Synthetic Antimicrobial Peptides and Their Antibacterial, Antifungal and Antiviral Mechanisms

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(1), С. 545 - 545

Опубликована: Янв. 4, 2022

Despite the great strides in healthcare during last century, some challenges still remained unanswered. The development of multi-drug resistant bacteria, alarming growth fungal infections, emerging/re-emerging viral diseases are yet a worldwide threat. Since discovery natural antimicrobial peptides able to broadly hit several pathogens, peptide-based therapeutics have been under lenses researchers. This review aims focus on synthetic and elucidate their multifaceted mechanisms action as antiviral, antibacterial antifungal agents. Antimicrobial generally affect highly preserved structures, e.g., phospholipid membrane via pore formation or other constitutive targets like peptidoglycans Gram-negative Gram-positive glucan cell wall. Additionally, particularly active biofilm destabilizing microbial communities. They can also act intracellularly, protein biosynthesis DNA replication. Their intracellular properties extended upon infection since influence steps along virus life cycle starting from receptor-cell interaction budding. Besides mode action, improvements manufacturing increase half-life performances taken into consideration together with advantages impairments clinical usage. Thus far, progress new approaches is making them promising tool counteract emerging infections.

Язык: Английский

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Recent advances in bio-based functional additives for polymers

Progress in Materials Science, Год журнала: 2023, Номер 139, С. 101186 - 101186

Опубликована: Сен. 7, 2023

In recent decades, the strong global concern on depletion of fossil fuel and environmental impact oil-based compounds has pushed towards more sustainable approaches in development polymer-based materials. This interest is driven by need a economy lower dependency fuels. this frame, replacement synthetic additives with natural polymer commodities progressively taking place. Additionally, according to forecasts, production bio-plastics will grow exponentially near future. However, these materials may exhibit poor physical mechanical properties regarding processability end-use, which can limit their potential for applications. Therefore, academic industrial communities are pushing fully bio-based formulations improved performance, tailored specific applications, ranging from packaging biomedicine. review presents most advances research functional polymeric For each type additive, both scientific fundamentals technological aspects encompassed, an emphasis current commercially available role market uptake environmentally friendly products. Finally, considerations about environmental, health, regulatory, economic issues related use bio-additives plastic also addressed.

Язык: Английский

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Flexible Modulation of Cellular Activities with Cationic Photosensitizers: Insights of Alkyl Chain Length on Reactive Oxygen Species Antimicrobial Mechanisms

Advanced Materials, Год журнала: 2023, Номер 35(35)

Опубликована: Май 26, 2023

Cationic photosensitizers have good binding ability with negatively charged bacteria and fungi, exhibiting broad applications potential in antimicrobial photodynamic therapy (aPDT). However, cationic often display unsatisfactory transkingdom selectivity between mammalian cells pathogens, especially for eukaryotic fungi. It is unclear which biomolecular sites are more efficient damage, owing to the lack of systematic research same photosensitizer system. Herein, a series aggregation-induced emission (AIE) derivatives (CABs) (using berberine (BBR) as core) different length alkyl chains successfully designed synthesized flexible modulation cellular activities. The BBR core can efficiently produce reactive oxygen species (ROS) achieve high-performance aPDT . Through precise regulation chain length, bindings, localizations, killing effects CABs achieved investigated systematically among bacteria, cells. found that intracellular active substances, not membranes, damage aPDT. Moderate enable effectively kill Gram-negative fungi light, while still maintaining excellent cell blood compatibility. This study expected provide theoretical strategic guidance construction selectivity.

Язык: Английский

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Structure–activity relationships of antibacterial peptides

Microbial Biotechnology, Год журнала: 2023, Номер 16(4), С. 757 - 777

Опубликована: Янв. 27, 2023

Abstract Antimicrobial peptides play a crucial role in innate immunity, whose components are mainly peptide‐based molecules with antibacterial properties. Indeed, the exploration of immune system over past 40 years has revealed number natural playing pivotal defence mechanisms vertebrates and invertebrates, including amphibians, insects, mammalians. This review provides discussion regarding agents their structure–activity relationships (SARs) aim describing topic that is not yet fully explored. Some growing evidence suggests immunity should be strongly considered for development novel antibiotic libraries. Also, due to constantly rising concern resistance, new drugs becoming priority global importance. Hence, study understanding phenomena occurring may inspire compound libraries set stage overcome drug‐resistant pathogens. Here, we provide an overview importance sources, focusing on accurately selected molecular structures, SARs recently introduced modifications, latest biotechnology applications, potential against multi‐drug resistant Last, cues describe how show better scope action selectivity than several anti‐infective agents, which characterized by non‐selective activities non‐targeted actions toward

Язык: Английский

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