Advances in tannic acid-incorporated biomaterials: Infection treatment, regenerative medicine, cancer therapy, and biosensing

Chemical Engineering Journal, Год журнала: 2021, Номер 432, С. 134146 - 134146

Опубликована: Дек. 29, 2021

Язык: Английский

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Carbon Dot Therapeutic Platforms: Administration, Distribution, Metabolism, Excretion, Toxicity, and Therapeutic Potential

Small, Год журнала: 2022, Номер 18(16)

Опубликована: Янв. 27, 2022

Abstract Ultrasmall nanoparticles are often grouped under the broad umbrella term of “nanoparticles” when reported in literature. However, for biomedical applications, their small sizes give them intimate interactions with biological species and endow unique functional physiochemical properties. Carbon quantum dots (CQDs) an emerging class ultrasmall which have demonstrated considerable biocompatibility been employed as potent theragnostic platforms. These particles find application increasing drug solubility targeting, along facilitating passage drugs across impermeable membranes (i.e., blood brain barrier). Further functionality can be triggered by various environmental conditions or external stimuli pH, temperature, near Infrared (NIR) light, ultrasound), intrinsic fluorescence is valuable diagnostic applications. The focus this review to shed light on therapeutic potential CQDs identify how they travel through body, reach site action, administer effect, excreted. Investigation into toxicity compatibility larger nanoparticle carriers also examined. future applications promising due multifunctional attributes documented biocompatibility. As nanomaterial platforms become more commonplace clinical treatments, commercialization CQD therapeutics anticipated.

Язык: Английский

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Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging

Theranostics, Год журнала: 2022, Номер 12(17), С. 7509 - 7531

Опубликована: Янв. 1, 2022

Lipid nanoparticles (LNPs) have been one of the most successful nano-delivery vehicles that enable efficient delivery cytotoxic chemotherapy agents, antibiotics, and nucleic acid therapeutics.During coronavirus disease (COVID-19) pandemic, LNP-based COVID-19 messenger RNA (mRNA) vaccines from Pfizer/BioNTech Moderna successfully developed, resulting in global sales $37 billion $17.7 billion, respectively, 2021.Based on this success, development multiple therapeutics is gaining momentum due to its potential for various genetic diseases cancers.Furthermore, imaging techniques can be utilized evaluate pharmacokinetics pharmacodynamics (PK/PD) effects, which helps target discovery accelerates mRNA therapies.A thorough introduction explanation components LNPs functions along with production methods formulating are provided review.Furthermore, recent advances clinics clinical trials explored.Additionally, evaluation PK/PD current roles developing pharmaceutics through will discussed.

Язык: Английский

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Lemon‐Derived Extracellular Vesicles Nanodrugs Enable to Efficiently Overcome Cancer Multidrug Resistance by Endocytosis‐Triggered Energy Dissipation and Energy Production Reduction

Advanced Science, Год журнала: 2022, Номер 9(20)

Опубликована: Фев. 20, 2022

Abstract Multidrug resistance remains a great challenge for cancer chemotherapy. Herein, biomimetic drug delivery system based on lemon‐derived extracellular vesicles (EVs) nanodrugs (marked with heparin‐cRGD‐EVs‐doxorubicin (HRED)) is demonstrated, achieving highly efficient overcoming multidrug resistance. The HRED fabricated by modifying functional heparin‐cRGD (HR) onto the surface of EVs and then loading doxorubicin (DOX). obtained enable to effectively enter DOX‐resistant cells caveolin‐mediated endocytosis (main), macropinocytosis (secondary), clathrin‐mediated (last), exhibiting excellent cellular uptake capacity. diversified capacity can efficiently dissipate intracellular energy meanwhile trigger downstream production reduction adenosine triphosphate (ATP), leading significant efflux. Consequently, they show anti‐proliferation capacities ovarian cancer, ensuring in vivo. authors believe this strategy provides new triggered‐energy dissipation ATP design

Язык: Английский

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(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy

Medicinal Research Reviews, Год журнала: 2023, Номер 43(6), С. 2115 - 2176

Опубликована: Май 11, 2023

Abstract Breast cancer is the most malignant tumor in women, and there no absolute cure for it. Although treatment modalities including surgery, chemotherapy, radiotherapy are utilized breast cancer, it still a life‐threatening disease humans. Nanomedicine has provided new opportunity treatment, which focus of current study. The nanocarriers deliver chemotherapeutic agents natural products, both increase cytotoxicity against cells prevent development drug resistance. efficacy gene therapy boosted by nanoparticles delivery CRISPR/Cas9, Noncoding RNAs, RNAi, promoting their potential expression regulation. codelivery can exert synergistic impact on tumors enhance cellular uptake via endocytosis. Nanostructures able to induce photothermal photodynamic ablation cell death induction. provide microenvironment remodeling repolarization macrophages antitumor immunity. stimuli‐responsive nanocarriers, pH‐, redox‐, light‐sensitive, mediate targeted suppression tumors. Besides, diagnosis detect biomarkers. Various kinds have been employed therapy, carbon‐, lipid‐, polymeric‐ metal‐based nanostructures, different terms biocompatibility efficiency.

Язык: Английский

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Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 200, С. 114990 - 114990

Опубликована: Июль 7, 2023

Язык: Английский

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Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Ноя. 19, 2022

Abstract Cancer is a major threat to human health. Among various treatment methods, precision therapy has received significant attention since the inception, due its ability efficiently inhibit tumor growth, while curtailing common shortcomings from conventional cancer treatment, leading towards enhanced survival rates. Particularly, organelle-targeted strategies enable precise accumulation of therapeutic agents in organelles, locally triggering organelle-mediated cell death signals which can greatly reduce threshold dosage and minimize side-effects. In this review, we comprehensively discuss history recent advances targeted therapies on specifically including nucleus, mitochondria, lysosomes endoplasmic reticulum, focusing organelle structures, signal pathways, design guidelines nanomedicines based intervention mechanisms. Furthermore, perspective future research clinical opportunities potential challenges oncology presented. Through demonstrating developments therapies, believe article further stimulate broader interests multidisciplinary technology development for enabling advanced their corresponding clinic translations.

Язык: Английский

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Tumor Abnormality-Oriented Nanomedicine Design

Chemical Reviews, Год журнала: 2023, Номер 123(18), С. 10920 - 10989

Опубликована: Сен. 15, 2023

Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain augmenting their therapeutic efficacy. Nanomedicines responsive to pathological abnormalities tumor microenvironment (TME) are expected overcome biological limitations conventional nanomedicines, enhance efficacies, and further reduce effects. This Review aims quantitate various TME, which may serve as unique endogenous stimuli for design stimuli-responsive provide a broad objective perspective on current understanding cancer treatment. We dissect typical transport process barriers drug delivery, highlight key principles designed tackle series delivery process, discuss "all-into-one" "one-for-all" strategies integrating needed properties nanomedicines. Ultimately, we insight into future perspectives toward clinical translation

Язык: Английский

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Engineered Macrophage-Membrane-Coated Nanoparticles with Enhanced PD-1 Expression Induce Immunomodulation for a Synergistic and Targeted Antiglioblastoma Activity

Nano Letters, Год журнала: 2022, Номер 22(16), С. 6606 - 6614

Опубликована: Авг. 10, 2022

Glioblastoma (GBM), the most common subtype of malignant gliomas, is characterized by aggressive infiltration, high malignancy, and poor prognosis. The frustrating anti-GBM outcome conventional therapeutics due to immunosuppressive milieu, in addition formidable obstacle blood-brain barrier (BBB). Combination therapy with an immune checkpoint blockade (ICB) has emerged as a critical component treatment GBM. Here, we report engineered macrophage-membrane-coated nanoplatform enhanced programmed cell death-1 (PD-1) expression (PD-1-MM@PLGA/RAPA). Using both vitro vivo GBM models, demonstrate that PD-1-MM@PLGA/RAPA can efficiently traverse across BBB response tumor microenvironment (TME) recruitment nanoparticles accumulating at site. Furthermore, show boosted result enhancing CD8+ cytotoxic T-lymphocyte (CTL) infiltration. Together provide new for ICB combination chemotherapy many other cancers.

Язык: Английский

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Polystyrene micro and nano-particles induce metabolic rewiring in normal human colon cells: A risk factor for human health

Chemosphere, Год журнала: 2022, Номер 303, С. 134947 - 134947

Опубликована: Май 14, 2022

Polystyrene is a thermoplastic polymer widely used in commercial products. Like all plastics, polystyrene can be degraded into microplastic and nanoplastic particles ingested via food chain contamination. Although the ecological impact due to plastic contamination well known, there are no studies indicating carcinogenic potential of microplastics (MPs) nanoplastics (NPs). Here, we evaluated effects MPs NPs on normal human intestinal CCD-18Co cells. Our results show that internalization induces metabolic changes under both acute chronic exposure by inducing oxidative stress, increasing glycolysis lactate sustain energy metabolism glutamine anabolic processes. We also this decoupling nutrients mirrors effect potent agent azoxymethane HCT15 colon cancer cells, carrying out typical strategy cells optimize utilization allowing adaptation environmental stress conditions. Taken together our data provide new evidence could act as risk factor for health.

Язык: Английский

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