Analytical Chemistry,
Год журнала:
2024,
Номер
96(31), С. 12739 - 12747
Опубликована: Июль 26, 2024
The
functionalization
of
metal-organic
frameworks
(MOFs)
with
organic
small
molecules
by
in
situ
postsynthetic
modification
has
garnered
considerable
attention.
However,
the
precise
engineering
recognition
sites
using
this
method
remains
rarely
explored
optically
controlled
bioelectronics.
Herein,
employing
Schiff
base
reaction
to
embed
molecule
(THBA)
into
a
Zr-MOF,
we
fabricated
hydroxyl-rich
MOF
on
surface
titanium
dioxide
nanorod
arrays
(U6H@TiO
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(17), С. 7631 - 7661
Опубликована: Янв. 1, 2022
G-Quadruplexes
represent
important
functional
constituents
in
biology,
chemistry,
nanotechnology,
and
material
science.
The
article
reviews
the
dynamic
reconfiguration
of
G-quadruplexes
their
applications
diverse
scientific
disciplines.
ACS Nano,
Год журнала:
2022,
Номер
16(9), С. 14503 - 14516
Опубликована: Сен. 6, 2022
Stroke
is
the
most
common
cause
of
disability
globally.
Neural
stem
cell
(NSC)
therapy,
which
can
replace
lost
and
damaged
neurons,
has
been
proposed
as
a
potential
treatment
for
stroke.
The
therapeutic
efficacy
NSC
therapy
hindered
by
fact
that
only
small
number
NSCs
undergo
neuronal
differentiation.
Neuron-specific
miR-124,
promotes
differentiation
into
mature
be
combined
with
to
cure
ischemic
However,
instability
poor
internalization
miR-124
seriously
hamper
its
broad
clinical
application.
Herein,
an
innovative
strategy
involving
delivery
via
Ca-MOF@miR-124
nanodelivery
system,
effectively
prevents
degradation
nucleases
NSCs,
presented.
effect
accelerated
directed
was
assessed
through
in
vitro
experiments,
application
this
system
stroke
vivo
experiments
combination
nanoparticles.
results
indicate
nanoparticles
promote
neurons
electrophysiological
function
within
5
days.
rate
cells
treated
at
least
days
faster
than
untreated
cells.
Moreover,
decreased
area
almost
normal
levels
day
7.
will
enhance
traumatic
nerve
injury
neurodegenerative
diseases.
Clustered
randomly
interspaced
short
palindromic
repeats
(CRISPRs)
and
its
associated
endonuclease
protein,
i.e.,
Cas9,
have
been
discovered
as
an
immune
system
in
bacteria
archaea;
nevertheless,
they
are
now
being
adopted
mainstream
biotechnological/molecular
scissors
that
can
modulate
ample
genetic
nongenetic
diseases
via
insertion/deletion,
epigenome
editing,
messenger
RNA
CRISPR
interference,
etc.
Many
Food
Drug
Administration-approved
ongoing
clinical
trials
on
adopt
ex
vivo
strategies,
wherein
the
gene
editing
is
performed
vivo,
followed
by
reimplantation
to
patients.
However,
delivery
of
components
still
under
preclinical
surveillance.
This
review
has
summarized
nonviral
nanodelivery
strategies
for
using
CRISPR/Cas9
recent
advancements,
strategic
points
view,
challenges,
future
aspects
tissue-specific
nanomaterials.
Materials Horizons,
Год журнала:
2023,
Номер
10(4), С. 1301 - 1308
Опубликована: Янв. 1, 2023
A
simple
yet
powerful
strategy
of
carrying
out
free
radical
polymerization
methacrylate
monomers
using
a
MOF-based
initiator.
The
obtained
composites
maintain
high
catalytic
activity
towards
chemical
warfare
agent
(CWA)
simulant.
Chemical Communications,
Год журнала:
2023,
Номер
59(20), С. 2869 - 2887
Опубликована: Янв. 1, 2023
Metal-organic
frameworks
(MOFs)
are
extremely
versatile
materials,
which
serve
to
create
platforms
with
exceptional
porosity
and
specific
reactivities.
The
production
of
MOFs
at
the
nanoscale
(NMOFs)
offers
possibility
creating
innovative
materials
for
bioapplications
as
long
they
maintain
properties
their
larger
counterparts.
Due
inherent
chemical
versatility,
synthetic
methods
produce
them
can
be
combined
inorganic
nanoparticles
(NPs)
nanocomposites
(NCs)
one-of-a-kind
features.
These
systems
remotely
controlled
catalyze
abiotic
reactions
in
living
cells,
have
potential
stimulate
further
research
on
these
tools
advanced
therapies.
Chemistry of Materials,
Год журнала:
2024,
Номер
36(8), С. 3588 - 3603
Опубликована: Апрель 11, 2024
The
development
of
nanoparticle
(NP)-based
drug
carriers
has
presented
an
exciting
opportunity
to
address
challenges
in
oncology.
Among
the
100,000
available
possibilities,
zirconium-based
metal–organic
frameworks
(MOFs)
have
emerged
as
promising
candidates
biomedical
applications.
Zr-MOFs
can
be
easily
synthesized
small-size
NPs
compatible
with
intravenous
injection,
whereas
ease
decorating
their
external
surfaces
functional
groups
allows
for
targeted
treatment.
Despite
these
benefits,
suffer
degradation
and
aggregation
real,
vivo
conditions,
loaded
drugs
will
burst
effect─i.e.,
fast
release
less
than
48
h.
To
tackle
issues,
we
developed
a
simple
but
effective
bilayer
coating
strategy
generic,
two-step
process.
In
this
work,
bilayer-coated
MOF
NU-901
remained
well
dispersed
biologically
relevant
fluids
such
buffers
cell
growth
media.
Additionally,
enhances
long-term
stability
drug-loaded
MOFs
water
by
simultaneously
preventing
sustained
leakage
particles.
We
evaluated
our
materials
encapsulation
transport
pemetrexed,
standard-of-care
chemotherapy
mesothelioma.
allowed
slowed
pemetrexed
over
7
days,
superior
typical
h
found
bare
MOFs.
This
slow
related
performance
were
studied
vitro
using
both
A549
lung
cancer
3T
mesothelioma
cells.
Using
high-resolution
microscopy,
successful
uptake
cells
accumulation
lysosomes.
pemetrex-loaded
was
indeed
cytotoxic
Finally,
demonstrated
general
approach
extending
two
additional
lipids
four
surfactants.
research
highlights
how
yet
provides
new
insights
into
design
MOF-based
delivery
systems.
Communications Materials,
Год журнала:
2024,
Номер
5(1)
Опубликована: Апрель 5, 2024
Abstract
Metal-organic
frameworks
(MOFs)
are
currently
widely
investigated
for
a
number
of
potential
biomedicinal
applications,
with
particular
focus
on
nanoscale
drug
delivery.
Nanomedicine
in
general
comes
specific
challenges
to
ensure
reproducibility
results,
including
batch-to-batch
variations
ostensibly
the
same
nanomaterial,
differences
synthetic
and
analytical
practices,
intrinsic
issues
vitro
culturing
assaying,
lack
availability
raw
data
comparative
analysis.
This
perspective
provides
an
overview
context
MOFs
nanomedicine,
covering
their
preparation
The
commonly
studied
UiO-66
is
used
as
exemplar
highlight
variability
characterisation
well
publication
data.
Some
common
roadblocks
highlighted,
alongside
suggestions
resources
best
practice.
Results in Chemistry,
Год журнала:
2024,
Номер
7, С. 101414 - 101414
Опубликована: Янв. 1, 2024
Metal-organic
frameworks
(MOFs)
have
emerged
as
a
class
of
versatile
materials,
finding
extensive
applications
in
drug
delivery
because
their
unique
properties
and
flexible
design.
This
comprehensive
review
aims
to
give
broad
perspective
on
the
recent
advancements
area
using
MOFs.
The
fundamental
characteristics
MOFs,
highlighting
exceptional
porosity,
high
surface
area,
tuneable
framework
structures,
enable
MOFs
serve
ideal
carriers,
allowing
efficient
loading
controlled
release.
delves
into
various
ligands
metal
ions
employed
for
encapsulation.
These
include
physical
encapsulation,
covalent
bonding,
host-guest
interactions,
each
offering
distinct
advantages
diverse
types
drugs
therapeutic
applications.
importance
tailoring
MOF
optimize
capacity,
stability,
release
kinetics
has
been
emphasized.
Additionally,
explorations
involve
delving
mechanisms
from
with
factors
such
pH,
temperature,
external
stimuli
that
can
be
harnessed
trigger
utilization
combination
therapies,
co-delivery
multiple
or
integrating
imaging
agents,
also
examined.
Numerous
examples
used
delivery,
encompassing
both
in-vitro
in-vivo
studies,
covering
wide
range
areas,
including
cancer
treatment,
antimicrobial
therapy,
targeted
are
included.
addresses
challenges
future
perspectives
development
delivery.
Strategies
improve
biocompatibility,
scalability
discussed,
along
understanding
MOF-drug
interaction
potential
toxicity
concerns.
With
properties,
capacities,
capabilities,
hold
capabilities
promise
enhance
efficacy
interventions.
Continued
research
this
pave
way
translation
clinical
near
future.
