Antioxidant Potential of Sea Cucumbers and Their Beneficial Effects on Human Health

Marine Drugs, Год журнала: 2022, Номер 20(8), С. 521 - 521

Опубликована: Авг. 15, 2022

Sea cucumbers are considered a luxury food item and used locally in traditional medication due to their impressive nutritional profile curative effects. contain wide range of bioactive compounds, namely phenolics, polysaccharides, proteins (collagen peptides), carotenoids, saponins, demonstrating strong antioxidant other activities. In particular, phenolic mainly acids flavonoids, abundant this marine invertebrate exhibit activity. Protein hydrolysates peptides obtained from sea potential, dependent on the amino acid compositions sequences as well molecular weight, displayed for those ≤20 kDa. Moreover, activity cucumber including fucosylated chondroitin sulfate fucan, is combination numerous factors mostly associated with degree sulfation, type major sugars. However, these compounds typically depends species, harvesting location, habit, body part, processing methods employed. This review summarizes by-products first time. The mechanism actions, chemical structures, affecting also discussed, along health benefits.

Язык: Английский

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Antioxidant peptides from edible aquatic animals: Preparation method, mechanism of action, and structure-activity relationships

Food Chemistry, Год журнала: 2022, Номер 404, С. 134701 - 134701

Опубликована: Окт. 22, 2022

Язык: Английский

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Production of Bioactive Peptides from Sea Cucumber and Its Potential Health Benefits: A Comprehensive Review

Journal of Agricultural and Food Chemistry, Год журнала: 2022, Номер 70(25), С. 7607 - 7625

Опубликована: Июнь 17, 2022

Bioactive peptides from food have been widely studied due to their potential applications as functional foods and pharmaceuticals. Sea cucumber, a traditional tonic food, is characterized by high protein low fat, thereby substrates are being release sea cucumber (SCPs). Although recent studies shown that SCPs various bioactive functions, there no literature reviewing the development status of SCPs. In this review, we summarized production SCPs, including purification identification, then mainly focused on comprehensive health benefits SCP in vivo vitro, finally discussed challenge facing We found well-documented antioxidation, anti-diabetes, ACE inhibitory, immunomodulatory, anti-cancer, anti-fatigue, anti-aging, neuroprotection, micromineral-chelating, etc. However, structure–activity relationships molecular mechanisms underlying regulation need further investigation. Research safety its mechanism will contribute transferring these findings into commercial applications. Hopefully, review could promote application investigation commercialization.

Язык: Английский

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Recent Progress in Antioxidant Active Substances from Marine Biota

Antioxidants, Год журнала: 2022, Номер 11(3), С. 439 - 439

Опубликована: Фев. 22, 2022

Background: The well-recognized but not fully explored antioxidant activity of marine-biota-derived, biologically active substances has led to interest in their study as substitutes antibiotics, antiaging agents, anticancer and antiviral drugs, others. aim this review is present the current state art marine-biota-derived antioxidants give some ideas for potential industrial applications. Methods: This an update last 5 years on marine sources natural antioxidants, different classes compounds, derivation biotechnologies. Results: New including byproducts wastes, are presented, along with new approaches. Conclusions: high-value from biota continues. Natural combining antimicrobial action particular because increasing microbial resistance antibiotic treatments. discovered, those extracted collected other locations. Byproducts wastes provide a valuable source substances. application optimized non-conventional approaches expected allow intensification production improvement quality derived ability obtain safe, products key importance industrialization.

Язык: Английский

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Potential Active Marine Peptides as Anti-Aging Drugs or Drug Candidates

Marine Drugs, Год журнала: 2023, Номер 21(3), С. 144 - 144

Опубликована: Фев. 23, 2023

Aging is an irreversible physiological process in the human body, and aging characteristics of body that accompany this also lead to many other chronic diseases, such as neurodegenerative diseases represented by Alzheimer’s disease Parkinson’s disease, cardiovascular hypertension, obesity, cancer, so on. The marine environment highly biodiverse, natural active products these organisms constitute a vast treasure trove drugs or drug candidates play essential role prevention treatment, peptide among them have received special attention because their unique chemical properties. Therefore, development compounds anti-aging emerging important research area. This review highlights currently available data on bioactive peptides with potential from 2000 2022 analyzing prevalent mechanisms, critical metabolic pathways well-established multi-omics characteristics, well grouping different biological species lines discussing modalities functional characteristics. Active promising topic explore develop candidates. We expect be instructive for future reveal new directions biopharmaceuticals.

Язык: Английский

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Characterization of the structure and analysis of the anti-oxidant effect of microalga Spirulina platensis polysaccharide on Caenorhabditis elegans mediated by modulating microRNAs and gut microbiota

International Journal of Biological Macromolecules, Год журнала: 2020, Номер 163, С. 2295 - 2305

Опубликована: Сен. 12, 2020

Язык: Английский

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Optimization ofJiuzaoprotein hydrolysis conditions and antioxidant activityin vivoofJiuzaotetrapeptide Asp-Arg-Glu-Leu by elevating the Nrf2/Keap1-p38/PI3K-MafK signaling pathway

Food & Function, Год журнала: 2021, Номер 12(11), С. 4808 - 4824

Опубликована: Янв. 1, 2021

Tetrapeptide DREL fromJiuzaoexhibits antioxidant and anti-inflammatory activities through activating the Nfr2/Keap1-p38/PI3K-MafK signaling pathway downstream enzymes.

Язык: Английский

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Antibacterial and antioxidant activity of sea cucumber extracts collected from Lampung waters, Indonesia

Kuwait Journal of Science, Год журнала: 2023, Номер 50(4), С. 615 - 621

Опубликована: Авг. 4, 2023

Sea cucumbers are the most prevalent marine invertebrates in Indonesian waters, yet little research has been conducted on bioactive substances found sea harvested from these waters. To investigate potential use of cucumber extracts and fractions such as antibacterial antioxidant agents, five species were Lampung waters Indonesia. The extraction process used maceration method with methanol solvent, while fractionation was carried out n-hexane, ethyl acetate, butanol solvents. activity evaluated using agar diffusion method, assessed ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) method. GC-MS to identify compounds extract fraction Holothuria lessoni. results showed that only n-hexane Stichopus quadrifasciatus H. lessoni had against Propionibacterium acnes, acetate leucospilota Staphylococcus aureus. S. Bohadschia marmorata recorded epidermidis. Among tested extracts, highest an IC50 value 155.07 ± 3.05 μg/mL, followed by (163.83 4.46 μg/mL), vastus (209.45 2.40 (245.85 34.97 B. (382.86 45.37 respectively. Cyclononasiloxane, octadecamethyl- (C18H54O9Si9), cyclohexasiloxane, dodecamethyl (C12H36O6Si), cyclooctasiloxane, hexadecamethyl- (C16H48O8Si8) identified main samples analysis. In conclusion, is a valuable source natural agents.

Язык: Английский

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Anti-aging activity and their mechanisms of natural food-derived peptides: current advancements

Food Innovation and Advances, Год журнала: 2023, Номер 2(4), С. 272 - 290

Опубликована: Янв. 1, 2023

Recently, there has been a growing focus on researching ways to delay aging and protect against age-related illnesses. Small molecular exogenous peptides, sourced from dietary elements like animals, plants, microorganisms, have demonstrated considerable potential in exerting anti-aging effects. Notably, natural food-derived peptides exhibited enhanced stability, safety, absorption efficiency, heightened biological activity. These attributes position them with greater for mitigating aging-related disorders compared alternative drugs or phytochemicals. This review summarizes the origins, structural attributes, isolation methods of properties. It also explores how these external improve conditions such as neurodegenerative diseases, skin aging, metabolic disorders. The underlying mechanisms dictating their impact well-conserved signaling pathways—encompassing oxidative stress, inflammation, apoptosis, collagen synthesis—are meticulously elucidated. paper engages an insightful exploration key challenges pivotal trajectories, grounded ongoing research endeavors. As result, this is poised offer authoritative scientific guidance invaluable support practical implementation realm applications within food, pharmaceutical, cosmetic industries.

Язык: Английский

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Unlocking the potential of chicken liver byproducts: Identification of antioxidant peptides through in silico approaches and anti-aging effects of a selected peptide in Caenorhabditis elegans

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 272, С. 132833 - 132833

Опубликована: Июнь 1, 2024

Язык: Английский

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