Chemistry & Biodiversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Abstract
Prinsepia
utilis
Royle,
known
for
its
diverse
applications
in
traditional
medicine
(Chinese
and
Indian
folk
medicines),
has
garnered
substantial
attention
within
the
field
of
phytochemistry
bioactivity
exploration.
P.
is
a
deciduous
shrub
from
family
Rosaceae
which
predominantly
distributed
Himalayan
Mountain
range
at
altitudes
ranging
1000
to
3000
meters
above
sea
level.
This
paper
mainly
focused
on
present
state
knowledge
about
,
focusing
compiling
comprehensive
current
database
encompassing
phytochemical
composition
associated
bioactivities.
Various
investigations
have
yielded
rich
repository
secondary
metabolites,
including
alkaloids,
flavonoids,
phenolics,
terpenoids.
studies
reported
bioactivities
attributed
extracts,
fractions,
or
isolated
compounds
showing
antioxidant,
anti‐inflammatory,
antimicrobial,
enzymatic
inhibitory
(α‐glucosidase
lipase),
immunosuppressive,
cytotoxic.
In
vivo
demonstrated
anti‐benign
prostatic
hyperplasia
effects,
osteoprotective,
hypoglycemic
activity
aligning
with
claims.
For
treatment
atrophic
dermatitis
acne
vulgaris,
formulations
containing
extract
been
developed
proven
effectiveness.
Furthermore,
exploration
highlights
promising
ability
as
source
novel
therapeutic
agents
functional
additives.
However,
further
are
required
integrate
pharmacological
evaluations,
clinical
trials,
sustainable
cultivation
practices
unlock
pharmaceutical
industrial
applications.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(2), С. 990 - 1009
Опубликована: Янв. 23, 2024
Skin
photoaging,
resulting
from
prolonged
exposure
to
ultraviolet
radiation,
is
a
form
of
exogenous
aging
that
not
only
impacts
the
aesthetic
aspect
skin
but
also
exhibits
strong
correlation
with
onset
cancer.
Nonetheless,
safety
profile
non-natural
anti-photoaging
medications
and
underlying
physiological
alterations
during
process
photoaging
remain
inadequately
elucidated.
Consequently,
there
exists
pressing
necessity
devise
more
secure
interventions
involving
drugs.
Multiple
studies
have
demonstrated
noteworthy
significance
marine
biomolecules
in
addressing
concerns
related
safeguarding
skin.
Notably,
bioactive
peptides
gained
considerable
attention
research
due
their
capacity
mitigate
associated
including
oxidative
stress;
inflammatory
response;
abnormal
expression
matrix
metalloproteinase,
hyaluronidase,
elastase;
excessive
melanin
synthesis.
This
review
provides
systematic
description
progress
on
protection
mechanism
peptides.
The
focus
utilization
as
agents,
aiming
offer
theoretical
references
for
development
novel
drugs
methodologies.
Additionally,
future
prospects
anti-aging
are
discussed,
providing
an
initial
reference
further
this
field.
Marine Drugs,
Год журнала:
2024,
Номер
22(4), С. 159 - 159
Опубликована: Март 30, 2024
Aging
is
closely
associated
with
collagen
degradation,
impacting
the
structure
and
strength
of
muscles,
joints,
bones,
skin.
The
continuous
aging
skin
a
natural
process
that
influenced
by
extrinsic
factors
such
as
UV
exposure,
dietary
patterns,
smoking
habits,
cosmetic
supplements.
Supplements
contain
can
act
remedies
help
restore
vitality
youth
to
skin,
helping
combat
aging.
Notably,
supplements
enriched
essential
amino
acids
proline
glycine,
along
marine
fish
collagen,
have
become
popular
for
their
safety
effectiveness
in
mitigating
process.
To
compile
relevant
literature
on
anti-aging
applications
search
analysis
peer-reviewed
papers
was
conducted
using
PubMed,
Cochrane
Library,
Web
Science,
Embase,
covering
publications
from
1991
2024.
From
vitro
vivo
experiments,
reviewed
studies
elucidate
benefits
emphasizing
its
role
combating
minimizing
oxidative
stress,
photodamage,
appearance
wrinkles.
Various
bioactive
peptides
exhibit
diverse
properties,
including
free
radical
scavenging,
apoptosis
inhibition,
lifespan
extension
various
organisms,
protective
effects
humans.
Furthermore,
topical
application
hyaluronic
acid
discussed
mechanism
increase
production
moisture,
contributing
supplementation.
integration
bio-tissue
engineering
also
explored,
highlighting
proven
utility
healing
bone
regeneration
applications.
However,
limitations
scope
exist.
Thus,
delving
into
these
nuanced
considerations,
this
review
contributes
comprehensive
understanding
potential
challenges
realm
Marine Drugs,
Год журнала:
2024,
Номер
22(4), С. 151 - 151
Опубликована: Март 28, 2024
Metabolic
disorders
are
increasingly
prevalent
conditions
that
manifest
pathophysiologically
along
a
continuum.
Among
reported
metabolic
risk
factors,
elevated
fasting
serum
glucose
(FSG)
levels
have
shown
the
most
substantial
increase
in
exposure.
Ultimately
leading
to
insulin
resistance
(IR),
this
condition
is
associated
with
notable
deteriorations
prognostic
outlook
for
major
diseases,
including
neurodegenerative
cancer
risk,
and
mortality
related
cardiovascular
disease.
Tackling
dysfunction,
focus
on
prevention,
critically
important
aspect
human
health.
In
study,
an
investigation
into
potential
antidiabetic
properties
of
salmon
protein
hydrolysate
(SPH)
was
conducted,
focusing
its
dipeptidyl
peptidase-IV
(DPP-IV)
inhibition
direct
uptake
vitro.
Characterization
SPH
utilized
bioassay-guided
fractionation
approach
identify
potent
glucoregulatory
peptide
fractions.
Low-molecular-weight
(MW)
fractions
prepared
by
membrane
filtration
(MWCO
=
3
kDa)
showed
significant
DPP-IV
(IC50
1.01
±
0.12
mg/mL)
vitro
(p
≤
0.0001
at
1
mg/mL).
Further
lowest
MW
(<3
derived
from
permeate
resulted
three
subfractions.
The
subfraction
molecular
weight
demonstrated
activity
0.0001),
maintaining
potency
even
dilution
1:500
0.01).
iScience,
Год журнала:
2024,
Номер
27(12), С. 111339 - 111339
Опубликована: Ноя. 7, 2024
As
the
global
population
continues
to
grow,
so
does
demand
for
longer,
healthier
lives
and
environmentally
responsible
choices.
Consumers
are
increasingly
drawn
naturally
sourced
products
with
proven
health
wellbeing
benefits.
The
marine
environment
presents
a
promising
yet
underexplored
resource
cosmetics
industry,
offering
bioactive
compounds
potential
safe
biocompatible
ingredients.
This
manuscript
provides
comprehensive
overview
of
organisms
production,
highlighting
marine-derived
their
applications
in
skin/hair/oral-care
products,
cosmeceuticals
more.
It
also
lays
down
critical
safety
considerations
addresses
methodologies
sourcing
compounds,
including
harvesting,
biorefinery
concept,
use
systems
biology
enhanced
product
development,
relevant
regulatory
landscape.
review
is
enriched
by
three
case
studies:
design
macroalgal
skincare
Iceland,
establishment
microalgal
spin-off
Italy,
utilization
proteins
cosmeceutical
applications.
Aging,
a
natural
process
occurring
in
both
normal
and
degenerative
conditions,
is
closely
associated
with
collagen
degradation,
impacting
various
bodily
systems
such
as
the
skin.
The
continuous
aging
of
skin,
influenced
by
intrinsic
extrinsic
factors,
underscores
importance
dermatological
cosmetic
contexts.
Notably,
supplements
enriched
essential
amino
acids
like
proline
glycine
along
marine
fish
have
become
popular
for
their
safety
effectiveness
mitigating
process.
To
compile
relevant
literature
on
anti-aging
applications
collagen,
systematic
search
analysis
peer-reviewed
papers
was
conducted
using
reputable
databases
including
PubMed,
Cochrane
Library,
Web
Science,
Embase,
covering
publications
from
1956
to
2023.
From
vitro
vivo
experiments,
reviewed
studies
elucidate
benefits
emphasizing
its
role
combating
skin
promoting
overall
health.
Many
bioactive
peptides
exhibit
diverse
properties,
free
radical
scavenging,
apoptosis
inhibition,
lifespan
extension
organisms,
protective
effects
humans.
Furthermore,
peptide
production
hyaluronic
acid
discussed
mechanism
fortify
enhance
moisture,
contributing
supplementation.
integration
bio-tissue
engineering
also
explored,
highlighting
proven
utility
addressing
bone
damage.
Insights
this
review
illuminate
biomedical
alongside
keystone
molecular
editing
tools
CRISPR,
positioning
it
versatile
resource
interventions.
However,
limitations
scope
application
exist.
Thus,
delving
into
these
nuanced
considerations,
contributes
comprehensive
understanding
potential
challenges
realm
applications.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(5), С. 3050 - 3060
Опубликована: Апрель 10, 2024
Peptides
are
a
promising
skincare
ingredient,
but
due
to
their
inherent
instability
and
the
barrier
function
of
skin's
surface,
they
often
have
limited
skin
absorption
penetration,
which
can
significantly
hinder
benefits.
To
address
this,
novel
technique
called
NanoGlow
has
been
introduced
for
encapsulating
peptide-based
cosmetic
raw
materials
into
engineered
nanosized
plant-derived
exosomes
(pExo)
achieve
goal
healthier
more
radiant
state.
In
this
approach,
pExo
served
as
carriers
peptides
across
intact
barrier,
enhancing
biological
effectiveness
in
beauty.
The
strategy
combines
chemical
activation
physical
proencapsulation,
boasting
high
success
rate
straightforward
stable
operation,
making
it
suitable
large-scale
production.
Comprehensive
analysis
using
Marine Drugs,
Год журнала:
2024,
Номер
22(4), С. 179 - 179
Опубликована: Апрель 17, 2024
Palmaria
palmata
is
a
viable
source
of
nutrients
with
bioactive
properties.
The
present
study
determined
the
potential
role
post-extraction
ultrasonication
on
some
compositional
features
and
antioxidant
properties
enzymatic/alkaline
extracts
P.
(EAEP).
No
significant
difference
was
detected
in
terms
protein
content
recovery,
as
well
amino
acid
composition
extracts.
nitrogen-to-protein
conversion
factor
5
found
to
be
too
high
for
seaweed
EAEP.
sonicated
by
bath
10
min
not
showed
highest
lowest
total
phenolic
contents
(p
<
0.05),
respectively.
radical
scavenging
metal-chelating
activities
were
observed
non-sonicated
sample,
evidenced
IC50
values.
extract
most
favorable
vitro
since
its
significantly
different
from
that
not-sonicated
sample
>
0.05).
In
contrast,
activity
higher
To
conclude,
an
ultrasonic
recommended
increase
improve
