Formation of a traditional Chinese medicine self-assembly nanostrategy and its application in cancer: a promising treatment

Chinese Medicine, Год журнала: 2023, Номер 18(1)

Опубликована: Июнь 6, 2023

Traditional Chinese medicine (TCM) has been used for centuries to prevent and treat a variety of illnesses, its popularity is increasing worldwide. However, the clinical applications natural active components in TCM are hindered by poor solubility low bioavailability these compounds. To address issues, self-assembly nanostrategy (CSAN) being developed. Many possess properties, allowing them form nanoparticles (NPs) through various noncovalent forces. Self-assembled NPs (SANs) also present decoctions, they closely linked therapeutic effects remedies. SAN gaining nano research field due simplicity, eco-friendliness, enhanced biodegradability biocompatibility compared traditional preparation methods. The ingredients from that exhibit antitumour or combined with other drugs generated considerable interest cancer therapeutics. This paper provides review principles forms CSAN, as well an overview recent reports on can be self-assembly. Additionally, application CSAN diseases summarized, finally, concluding summary thoughts proposed. We strongly believe potential offer fresh strategies perspectives modernization TCM.

Язык: Английский

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Prevention effect of total ginsenosides and ginseng extract from Panax ginseng on cyclophosphamide‐induced immunosuppression in mice

Phytotherapy Research, Год журнала: 2023, Номер 37(8), С. 3583 - 3601

Опубликована: Апрель 18, 2023

Oral decoction is widely applied in traditional Chinese medicines. The polysaccharides of promote the exposure small molecules and increase their bioavailability. This study mainly compared component activities total ginsenosides (TGS) ginseng extract (GE) on immunosuppressed mice induced by cyclophosphamide. Thirty-two were randomly divided into control, model, TGS, GE groups. orally administered for 28 days then injected with cyclophosphamide last four days. results analysis showed content 12 TGS (67.21%) was higher than (2.04%); 17 amino acids (1.41%) lower (5.36%); 10 monosaccharides similar (74.12%) (76.36%). animal that both protected hematopoietic function bone marrow inhibiting cell apoptosis, recovering normal cycle BM; maintained dynamic balance between Th1 Th2 cells; also spleen, thymus, liver. Meanwhile, intestinal bacteria increasing abundance lactobacillus decreasing odoribacter clostridia_UCG-014. prevention effect superior to some parameters. In conclusion, immune bioavailability bioactivity because synergistic plays an important role protecting function.

Язык: Английский

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Research progress on the structural characterization, biological activity and product application of polysaccharides from Crataegus pinnatifida

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 244, С. 125408 - 125408

Опубликована: Июнь 19, 2023

Язык: Английский

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Ginseng polysaccharide components attenuate obesity and liver lipid accumulation by regulating fecal microbiota and hepatic lysine degradation

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 131872 - 131872

Опубликована: Апрель 25, 2024

The increasing incidence of obesity has led to widespread attention in the exploration natural ingredients. Ginseng polysaccharides (PGP), main components from Panax ginseng, have been reported potential effect attenuate and regulate lipid metabolism. In this study, we found that PGP inhibited high-fat diet (HFD)-induced weight gain, fat ratio tissue after 8-week administration. Serum liver analysis showed decreased levels triglyceride total cholesterol, which was mediated by inhibition key genes for fatty acid cholesterol metabolisms. Metabolomics studies inhibitory on accumulation significantly correlated with its regulation citric cycle lysine degradation. regulated expression related degradation both hepatocytes. addition, reshaped composition fecal microbiota at genus species obese mice. Spearman's correlation demonstrated Staphylococcus sciuri, lentus, Pseudoflavonifractor sp. An85 may be targets maintains abundance l-lysine against obesity. It concluded can regulating hepatic

Язык: Английский

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Advancements in enzymatic biotransformation and bioactivities of rare ginsenosides：A Review

Journal of Biotechnology, Год журнала: 2024, Номер 392, С. 78 - 89

Опубликована: Июнь 28, 2024

Язык: Английский

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