Biomaterials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
The
popularity
of
medicinal
plants,
which
have
a
unique
system
and
are
mostly
used
in
compound
form
for
the
prevention
treatment
wide
range
diseases,
is
growing
worldwide.
In
recent
years,
with
advances
chemical
separation
structural
analysis
techniques,
many
major
bioactive
molecules
plants
been
identified.
However,
active
ingredients
often
possess
characteristics,
including
poor
water
solubility,
stability
bioavailability,
limit
their
therapeutic
applications.
To
address
this
problem,
self-assembly
small
from
food
sources
provides
new
strategy.
Driven
by
various
types
acting
forces,
modifiable
groups,
multiple
sites
action,
hydrophobic
side
chains,
rigid
backbones
properties
able
to
supramolecular
network
hydrogels,
nanoparticles,
micelles,
other
self-assemblies.
This
review
first
summarizes
forms
self-assemblies
such
as
micelles
at
level
action
site,
discusses
studies
on
that
can
be
self-assembly,
addition
summarizing
advantages
variety
disease
applications,
wound
healing,
antitumor,
anticancer,
diabetes
mellitus.
Finally,
problems
self-assemblers
possible
directions
future
development
presented.
We
firmly
believe
potential
develop
effective
compounds
drug-food
homologous
providing
valuable
information
drug
research
strategies
perspectives
modernization
Chinese
medicine.
Biomaterials Science,
Год журнала:
2024,
Номер
12(7), С. 1662 - 1692
Опубликована: Янв. 1, 2024
In
this
review,
we
have
summarized
the
common
self-assembled
mechanism
of
NSMs-based
SANDDSs.
Meanwhile,
potential
applications
for
cancer
treatment
and
future
development
prospects
are
also
prospected.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 14, 2024
In
the
past
11
years,
there
has
been
a
surge
in
studies
exploring
regulatory
effect
of
Traditional
Chinese
Medicine
(TCM)
on
ferroptosis.
However,
significant
gap
persists
comprehensive
scientometric
analysis
and
scientific
mapping
research,
especially
tracking
evolution,
primary
contributors,
emerging
research
focal
points.
This
study
aims
to
comprehensively
update
advancements
targeting
ferroptosis
with
various
TCMs
during
previous
years.
The
data,
covering
period
from
1
January
2012,
30
November
2023,
were
retrieved
Web
Science
database.
For
in-depth
visualized
analyses,
series
advanced
analytical
instruments
employed.
findings
highlight
China’s
predominant
role,
accounting
for
71.99%
total
publications
significantly
shaping
this
domain.
Noteworthy
productivity
was
observed
at
institutions,
including
Guangzhou
University
Medicine,
Chengdu
Zhejiang
University.
Thomas
Efferth
emerged
as
foremost
author
within
field,
while
Frontiers
Pharmacology
boasted
highest
publication
count.
pinpointed
hepatocellular
carcinoma,
chemical
drug-induced
liver
injury,
mitochondrial
diseases,
acute
kidney
failure
most
critical
disorders
addressed
realm.
offers
bibliometric
evaluation,
enhancing
our
understanding
present
status
TCM
therapy
managing
ferroptosis-related
diseases.
Consequently,
it
aids
both
seasoned
researchers
newcomers
by
accelerating
access
vital
information
fostering
innovative
concept
extraction
specialized
field.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 1, 2024
Abstract
Background
Herbal
nanoparticles
are
made
from
natural
herbs/medicinal
plants,
their
extracts,
or
a
combination
with
other
nanoparticle
carriers.
Compared
to
traditional
herbs,
herbal
lead
improved
bioavailability,
enhanced
stability,
and
reduced
toxicity.
Previous
research
indicates
that
medicine
nanomaterials
rapidly
advancing
making
significant
progress;
however,
bibliometric
analysis
knowledge
mapping
for
currently
lacking.
We
performed
by
retrieving
publications
related
the
Web
of
Science
Core
Collection
(WoSCC)
database
spanning
2004
2023.
Data
processing
was
using
R
package
Bibliometrix,
VOSviewers,
CiteSpace.
Results
In
total,
1876
articles
were
identified,
originating
various
countries,
China
being
primary
contributing
country.
The
number
in
this
field
increases
annually.
Beijing
University
Chinese
Medicine,
Shanghai
Traditional
Saveetha
India
prominent
institutions
domain.
Journal
“International
Nanomedicine”
has
highest
publications.
authors
these
reached
8234,
Yan
Zhao,
Yue
Zhang,
Huihua
Qu
most
prolific
Zhao
frequently
cited
author.
“Traditional
medicine,”
“drug
delivery,”
“green
synthesis”
main
focal
points.
Themes
such
as
synthesis,”
“curcumin,”
“wound
healing,”
“carbon
dots”
may
represent
emerging
areas.
Conclusions
Our
study
findings
assist
identifying
latest
frontiers
hot
topics,
providing
valuable
references
scholars
investigating
role
nanotechnology
medicine.
Graphical
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 14, 2025
There
are
abundant
natural
products
resources
and
extensive
clinical
use
experience
in
China.
However,
the
active
components
of
generally
have
problems
such
as
poor
water
solubility
low
bioavailability,
which
limit
their
druggability.
Carrier-free
nanoparticles,
nanocrystals,
self-assembled
extracellular
vesicles
derived
from
both
animal
plant
sources,
great
application
potential
improving
safety
efficacy
drugs
due
to
simple
flexible
preparation
methods,
high
drug
loading
capacity
delivery
efficiency,
well
long
half-life
blood
circulation.
It
has
been
widely
used
biomedical
fields
anti-tumor,
anti-bacterial,
anti-inflammatory
anti-oxidation.
Therefore,
based
on
that
clinic,
this
review
focuses
advantages
carrier-free
nanoparticles
delivering
compounds,
order
improve
process
vivo
draggability.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 6705 - 6724
Опубликована: Ноя. 1, 2023
Enhancing
the
dissolution,
permeation
and
absorption
of
active
components
with
low
solubility
poor
permeability
is
crucial
for
maximizing
therapeutic
efficacy
optimizing
functionality.
The
objective
this
study
to
investigate
potential
natural
polysaccharides
as
carriers
improve
biopharmaceutical
properties
components.In
study,
we
employed
four
representative
flavonoids
in
Astragali
Radix,
namely
Calycosin-7-O-β-D-glucoside
(CAG),
Ononin
(ON),
Calycosin
(CA)
Formononetin
(FMN),
a
demonstration
evaluate
Astragalus
(APS)
properties,
sush
solubility,
permeability,
vivo.
In
addition,
microstructure
flavonoids-APS
complexes
was
characterized,
interaction
mechanism
between
APS
investigated
using
multispectral
technique
molecular
dynamics
simulation.The
results
showed
that
can
self-assemble
into
aggregates
porous
structure
large
surface
area
aqueous
solutions.
These
be
loaded
through
weak
intermolecular
interactions,
such
hydrogen
bonding,
thereby
improving
their
gastrointestinal
stability,
vivo.We
discovered
self-assembly
its
carriers.
Compared
introducing
external
excipients,
utilization
plants
may
have
unique
advantage
enhancing
absorption.
Acute
liver
failure
(ALF)
is
a
rare
and
serious
condition
characterized
by
major
hepatocyte
death
dysfunction.
Owing
to
the
limited
therapeutic
options,
this
disease
generally
has
poor
prognosis
high
mortality
rate.
When
ALF
cannot
be
reversed
medications,
transplantation
often
needed.
However,
transplant
rejection
shortage
of
donor
organs
still
remain
challenges.
Most
recently,
stem
cell
therapy
emerged
as
promising
alternative
for
treatment
diseases.
delivery
routes
stability
live
products
have
greatly
hindered
feasibility
efficacy
therapy.
Inspired
functions
mesenchymal
cells
(MSCs)
primarily
through
secretion
several
factors,
we
developed
an
MSC-inspired
biomimetic
multifunctional
nanoframework
(MBN)
that
encapsulates
growth-promoting
factors
secreted
MSCs
via
combination
with
hydrophilic
or
hydrophobic
drugs.
The
red
blood
(RBC)
membrane
was
coated
MBN
enhance
its
immunological
tolerance
prolong
circulation
time
in
blood.
Importantly,
can
respond
oxidative
microenvironment,
where
it
accumulates
degrades
release
payload.
In
work,
two
nanoparticles,
namely,
rhein-encapsulated
(RMBN)
N-acetylcysteine
(NAC)-encapsulated
(NMBN),
were
designed
synthesized.
lipopolysaccharide
(LPS)/d-galactosamine
(D-GalN)-induced
acetaminophen
(APAP)-induced
mouse
models,
RMBN
NMBN
could
effectively
target
lesions,
relieve
acute
symptoms
ALF,
promote
regeneration
virtue
their
strong
antioxidative,
anti-inflammatory,
regenerative
activities.
This
study
demonstrated
use
treating
ALF.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
Natural
bioactive
compounds
from
plants
exhibit
substantial
pharmacological
potency
and
therapeutic
value.
However,
the
development
of
most
plant
is
hindered
by
low
solubility
instability.
Conventional
pharmaceutical
forms,
such
as
tablets
capsules,
only
partially
overcome
these
limitations,
restricting
their
efficacy.
With
recent
nanotechnology,
nanocarriers
can
enhance
bioavailability,
stability,
precise
intracellular
transport
compounds.
Researchers
are
increasingly
integrating
nanocarrier‐based
drug
delivery
systems
(NDDS)
into
natural
with
significant
success.
Moreover,
products
benefit
nanotechnological
enhancement
contribute
to
innovation
optimization
via
self‐assembly,
grafting
modifications,
biomimetic
designs.
This
review
aims
elucidate
collaborative
reciprocal
advancement
achieved
botanical
products,
compounds,
polysaccharides,
proteins,
extracellular
vesicles.
underscores
salient
challenges
in
nanomedicine,
encompassing
long‐term
safety
evaluations
nanomedicine
formulations,
targeting
mechanisms,
biodistribution
complexities,
hurdles
clinical
translation.
Further,
this
study
provides
new
perspectives
leverage
nanotechnology
promoting
for
nanomedical
applications
guiding
progression
NDDS
toward
enhanced
efficiency,
precision,
safety.
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Nanotechnology
Biology
Nanoscale
Systems
Engineering,
Год журнала:
2024,
Номер
40, С. 28 - 50
Опубликована: Апрель 26, 2024
This
research
introduces
a
systems
theory-driven
framework
to
integration
artificial
intelligence
(AI)
into
traditional
Chinese
medicine
(TCM)
research,
enhancing
the
understanding
of
TCM's
holistic
material
basis
while
adhering
evidence-based
principles.
Utilizing
System
Function
Decoding
Model
(SFDM),
progresses
through
define,
quantify,
infer,
and
validate
phases
systematically
explore
basis.
It
employs
dual
analytical
approach
that
combines
top-down,
theory-guided
perspectives
with
bottom-up,
elements–structure–function
methodologies,
provides
comprehensive
insights
Moreover,
examines
AI's
role
in
quantitative
assessment
predictive
analysis
components,
proposing
two
specific
AI-driven
technical
applications.
interdisciplinary
effort
underscores
potential
enhance
our
establishes
foundation
for
future
at
intersection
wisdom
modern
technology.
