Wearable Electrochemical Glucose Sensors in Diabetes Management: A Comprehensive Review

Chemical Reviews, Год журнала: 2023, Номер 123(12), С. 7854 - 7889

Опубликована: Май 30, 2023

With the rising diabetic population, demand for glucose sensing devices has also been on an increasing trend. Accordingly, field of biosensors diabetes management witnessed tremendous scientific and technological advancements since introduction first enzymatic biosensor in 1960s. Among these, electrochemical hold considerable potential tracking dynamic profiles real time. The recent evolution wearable opened opportunities to use alternative body fluids a pain-free, noninvasive or minimally invasive manner. This review aims present comprehensive report about status promise sensors on-body monitoring. We start by highlighting importance how can contribute toward its effective then discuss mechanisms, such over time, different versions targeting various biofluids, multiplexed optimal management. Finally, we focus commercial aspects biosensors, starting with existing continuous monitors, followed other emerging technologies, concluding key prospects personalized connection autonomous closed-loop artificial pancreas.

Язык: Английский

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High‐Resolution 3D Printing for Electronics

Advanced Science, Год журнала: 2022, Номер 9(8)

Опубликована: Янв. 17, 2022

The ability to form arbitrary 3D structures provides the next level of complexity and a greater degree freedom in design electronic devices. Since recent progress electronics has expanded their applicability various fields which structural conformability dynamic configuration are required, high-resolution printing technologies can offer significant potential for freeform electronics. Here, novel methods is reviewed, with providing comprehensive study on 3D-printable functional materials processes device components. latest advances 3D-printed also reviewed explain representative components, including interconnects, batteries, antennas, sensors. Furthermore, key challenges prospects next-generation printed considered, future directions explored based research that emerged recently.

Язык: Английский

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Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Advanced Materials, Год журнала: 2022, Номер 34(24)

Опубликована: Фев. 7, 2022

Abstract The eye is one of the most complex organs in human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, pH) as well a library metabolite biomarkers glucose, proteins, specific ions). Smart contact lenses (SCLs) can serve wearable intelligent ocular prosthetic device capable noninvasive continuous monitoring various essential physical/biochemical parameters drug loading/delivery for treatment diseases. Advances SCL technologies growing public interest personalized health are accelerating research more than ever before. Here, current status potential development through comprehensive review from fabrication to applications commercialization discussed. First, material, fabrication, platform designs SCLs diagnostic therapeutic Then, latest advances clinical translation reviewed. Later, established techniques power transfer wireless data transmission applied devices summarized. An outlook, future opportunities, challenges developing next‐generation also provided. With rise development, this new paradigm devices.

Язык: Английский

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Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

Chemical Reviews, Год журнала: 2023, Номер 123(19), С. 11488 - 11558

Опубликована: Сен. 25, 2023

The eye contains a complex network of physiological information and biomarkers for monitoring disease managing health, ocular devices can be used to effectively perform point-of-care diagnosis management. This comprehensive review describes the target various diseases, including ophthalmic metabolic neurological based on anatomical background eye. also includes recent technologies utilized in eye-wearable medical latest trends wearable devices, specifically smart contact lenses purpose After introducing other such as retinal prosthesis, we further discuss current challenges potential possibilities lenses.

Язык: Английский

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Liquid-metal-based three-dimensional microelectrode arrays integrated with implantable ultrathin retinal prosthesis for vision restoration

Nature Nanotechnology, Год журнала: 2024, Номер 19(5), С. 688 - 697

Опубликована: Янв. 15, 2024

Abstract Electronic retinal prostheses for stimulating neurons are promising vision restoration. However, the rigid electrodes of conventional implants can inflict damage on soft retina tissue. They also have limited selectivity due to their poor proximity target cells in degenerative retina. Here we present a artificial (thickness, 10 μm) where flexible ultrathin photosensitive transistors integrated with three-dimensional stimulation eutectic gallium–indium alloy. Platinum nanoclusters locally coated only tip these liquid-metal show advantages reducing impedance electrodes. These microelectrodes enhance ganglion and provide effective charge injections (72.84 mC cm −2 ) elicit neural responses Their low Young’s modulus (234 kPa), owing liquid form, minimize Furthermore, used an unsupervised machine learning approach effectively identify evoked spikes grade activities within cells. Results from vivo experiments degeneration mouse model reveal that spatiotemporal distribution be mapped under selective localized illumination areas light, suggesting restoration vision.

Язык: Английский

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Material and structural considerations for high-performance electrodes for wearable skin devices

Communications Materials, Год журнала: 2024, Номер 5(1)

Опубликована: Апрель 11, 2024

Abstract Wearable skin-contacting devices are extensively studied for their ability to provide convenient and safe health monitoring. A key aspect that controls performance the properties of device electrodes. Optimizing electrode structure, materials they made from, can improve functionality. Here, we discuss various required optimal performance, including mechanical, electrical, biocompatible factors. To address these challenges, consider alteration development flexible or soft conductive materials, creation hybrid structures. Additionally, integration artificial intelligence is proposed as a promising direction achieve smart devices. As well outlining essential characteristics high-performance wearable skin also offer insight into possible future applications.

Язык: Английский

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Wireless Non‐Invasive Monitoring of Cholesterol Using a Smart Contact Lens

Advanced Science, Год журнала: 2022, Номер 9(28)

Опубликована: Авг. 17, 2022

Abstract Herein, a wireless and soft smart contact lens that enables real‐time quantitative recording of cholesterol in tear fluids for the monitoring patients with hyperlipidemia using smartphone is reported. This incorporates an electrochemical biosensor continuous detection concentrations, stretchable antenna, integrated circuits communication, which makes only device required to operate this remotely without obstructing wearer's vision. The rabbit model utilized confirm correlation between levels fluid blood feasibility diagnostic application cholesterol‐related diseases. Further vivo tests human subjects demonstrated its good biocompatibility, wearability, reliability as non‐invasive healthcare device.

Язык: Английский

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A Soft Wearable Microfluidic Patch with Finger-Actuated Pumps and Valves for On-Demand, Longitudinal, and Multianalyte Sweat Sensing

ACS Sensors, Год журнала: 2022, Номер 7(10), С. 3169 - 3180

Опубликована: Окт. 17, 2022

Easy sample collection, physiological relevance, and ability to noninvasively longitudinally monitor the human body are some of key attributes wearable sweat sensors. Examples typically include reversible sensors or an array single-use embedded in specialized microfluidics for temporal analysis sweat. However, evolving this field a level that truly represents "lab-on-skin" technology will require incorporation advanced functionalities give user freedom (1) choose precise time performing (2) select from within device condition-specific analysis. Here, we introduce new concepts microfluidic platforms offer such capabilities. The described involves series finger-actuated pumps, valves, incorporated soft, microfluidics. incoming collects inlet chamber can be analyzed by at their choosing. On-demand analyte assessment is achieved pulling thin tab activate pump which opens valve allows pooled enter with desired analytes. article describes thorough characterization platform demonstrates robustness pumping, valving, sensing aspects under conditions mimicking real-life scenarios. A two-day-long pilot study validates system illustrates device's on-demand, longitudinal, multianalyte sensing. Our work first example on-demand capabilities exciting avenues acquiring insights into physiology.

Язык: Английский

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TFOS Lifestyle: Impact of contact lenses on the ocular surface

The Ocular Surface, Год журнала: 2023, Номер 29, С. 175 - 219

Опубликована: Май 4, 2023

Язык: Английский

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Soft Bioelectronics for Therapeutics

ACS Nano, Год журнала: 2023, Номер 17(18), С. 17634 - 17667

Опубликована: Сен. 7, 2023

Soft bioelectronics play an increasingly crucial role in high-precision therapeutics due to their softness, biocompatibility, clinical accuracy, long-term stability, and patient-friendliness. In this review, we provide a comprehensive overview of the latest representative therapeutic applications advanced soft bioelectronics, ranging from wearable for skin wounds, diabetes, ophthalmic diseases, muscle disorders, other diseases implantable against complex such as cardiac arrhythmias, cancer, neurological others. We also highlight key challenges opportunities future translation commercialization toward personalized medicine.

Язык: Английский

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