Ga‐Based Liquid Metals: Versatile and Biocompatible Solutions for Next‐Generation Bioelectronics DOI Open Access
Won Gi Chung, Enji Kim, Yong Won Kwon

и другие.

Advanced Functional Materials, Год журнала: 2023, Номер 34(31)

Опубликована: Дек. 6, 2023

Abstract The utilization of gallium (Ga)‐based liquid metals (LMs) as functional materials in bioelectronics has been extensively explored over the past decade a key to stimulation biological systems and recording signals. motivation behind this class electronics is driven by opportunities exploit mechanical properties similar tissues. These bioelectronic devices are required maintain functionality under deformation and, especially for implantable applications, should interface with tissues minimally invasive manner. LMs attractive such applications due their ability deform while retaining electrical conductivity. Furthermore, unlike most liquids that form droplets minimize surface energy, ultrathin solid‐state oxide layer on outer enables them be shaped specific 3D patterns. Unlike mercury, Ga‐based considered biocompatible low toxicity vapor pressure, highlighting potential advantageous bioelectronics. This review comprehensively presents fundamental aspects these materials, focus effectiveness stimulating tissues, well diverse soft stretchable electrodes Additionally, investigates additional strategies aimed at driving future advancements field.

Язык: Английский

Incorporating Wireless Strategies to Wearable Devices Enabled by a Photocurable Hydrogel for Monitoring Pressure Information DOI

Yunjian Guo,

Feifei Yin, Yang Li

и другие.

Advanced Materials, Год журнала: 2023, Номер 35(29)

Опубликована: Март 31, 2023

Advances in emerging technologies for wireless collection and the timely analysis of various information captured by wearable devices are growing interest. Herein, a crosslinked ionic hydrogel prepared facile photocuring process is proposed, which allows to be further incorporated into two integrated systems pressure monitoring applications. The device exhibits simplified structure effectively sharing functional layers, rather than conventional separate combinations, offering salient performance iontronic sensing electrochromic properties simultaneously quantify visualize pressure. developed smart patch system demonstrated monitor physiological signals real-time utilizing user interface remote portable equipment with Bluetooth protocol on-site displays. Moreover, passive based on magnetic coupling effect designed, can operate free from battery acquire multiple information. It envisioned that strategies would hold enormous potential flexible electronics, versatile platforms, on-body networks.

Язык: Английский

Процитировано

100

Biosensors for healthcare: current and future perspectives DOI

Eun Ryung Kim,

Cheulmin Joe,

Robert J. Mitchell

и другие.

Trends in biotechnology, Год журнала: 2022, Номер 41(3), С. 374 - 395

Опубликована: Дек. 23, 2022

Язык: Английский

Процитировано

91

Flexible and Stretchable Electrochemical Sensors for Biological Monitoring DOI
Yi Zhao,

Kai‐Qi Jin,

Jing‐Du Li

и другие.

Advanced Materials, Год журнала: 2023, Номер unknown

Опубликована: Авг. 28, 2023

The rise of flexible and stretchable electronics has revolutionized biosensor techniques for probing biological systems. Particularly, electrochemical sensors (FSECSs) enable the in situ quantification numerous biochemical molecules different entities owing to their exceptional sensitivity, fast response, easy miniaturization. Over past decade, fabrication application FSECSs have significantly progressed. This review highlights key developments electrode functionalization. It delves into sensing various biomarkers, including metabolites, electrolytes, signaling molecules, neurotransmitters from systems, encompassing outer epidermis, tissues/organs vitro vivo, living cells. Finally, considering preparation applications, current challenges future opportunities are discussed.

Язык: Английский

Процитировано

71

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management DOI Creative Commons
Hunkyu Seo, Won Gi Chung, Yong Won Kwon

и другие.

Chemical Reviews, Год журнала: 2023, Номер 123(19), С. 11488 - 11558

Опубликована: Сен. 25, 2023

The eye contains a complex network of physiological information and biomarkers for monitoring disease managing health, ocular devices can be used to effectively perform point-of-care diagnosis management. This comprehensive review describes the target various diseases, including ophthalmic metabolic neurological based on anatomical background eye. also includes recent technologies utilized in eye-wearable medical latest trends wearable devices, specifically smart contact lenses purpose After introducing other such as retinal prosthesis, we further discuss current challenges potential possibilities lenses.

Язык: Английский

Процитировано

59

Wireless Technologies in Flexible and Wearable Sensing: From Materials Design, System Integration to Applications DOI

Lingyan Kong,

Weiwei Li,

Tinghao Zhang

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(27)

Опубликована: Апрель 23, 2024

Wireless and wearable sensors attract considerable interest in personalized healthcare by providing a unique approach for remote, noncontact, continuous monitoring of various health-related signals without interference with daily life. Recent advances wireless technologies have promoted practical applications due to their significantly improved characteristics, such as reduction size thickness, enhancement flexibility stretchability, conformability the human body. Currently, most researches focus on active materials structural designs sensors, just few exceptions reflecting data transmission. This review provides comprehensive overview state-of-the-art related studies empowering sensors. The emerging functional nanomaterials utilized designing modules are highlighted, which include metals, carbons, MXenes. Additionally, outlines system-level integration flexible spanning from novel design strategies enhanced efficient transmitting wirelessly. Furthermore, introduces representative remote noninvasive physiological through on-skin implantable sensing systems. Finally, challenges, perspectives, unprecedented opportunities discussed.

Язык: Английский

Процитировано

57

Wearable and implantable bioelectronics as eco‐friendly and patient‐friendly integrated nanoarchitectonics for next‐generation smart healthcare technology DOI Creative Commons
Suhyeon Kim, Seungho Baek, Ronald Sluyter

и другие.

EcoMat, Год журнала: 2023, Номер 5(8)

Опубликована: Май 8, 2023

Abstract Since the beginning of human history, demand for effective healthcare systems diagnosis and treatment health problems has grown steadily. However, traditional centralized requires hospital visits, making in‐time long‐term challenging. Bioelectronics shown potential in patient‐friendly owing to rapid advances diverse fields biology electronics. In particular, wearable implantable bioelectronics have emerged as an alternative or adjunct conventional healthcare. To develop into next‐generation systems, however, custom designs biological targets with a deepened understanding intrinsic features target are essential. addition, bioelectronic must be designed eco‐friendly sustainable this review, integrated nanoarchitectonics smart technology described. For in‐depth guidelines target‐tailored design, we discuss target‐specific considerations relevant key parameters representative examples. image

Язык: Английский

Процитировано

48

In-depth correlation analysis between tear glucose and blood glucose using a wireless smart contact lens DOI Creative Commons
Wonjung Park, Hunkyu Seo, Jeongho Kim

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Апрель 2, 2024

Abstract Tears have emerged as a promising alternative to blood for diagnosing diabetes. Despite increasing attempts measure tear glucose using smart contact lenses, the controversy surrounding correlation between and still limits clinical usage of tears. Herein, we present an in-depth investigation wireless soft lens continuous monitoring glucose. This is capable quantitatively levels in basal tears excluding effect reflex which might weaken relationship with Furthermore, this can provide unprecedented level data acquisition at sub-minute intervals. These advantages allow precise estimation lag time, enabling establishment concept called ‘personalized time’. demonstration considers individual differences successfully applied both non-diabetic diabetic humans, well animal models, resulting high correlation.

Язык: Английский

Процитировано

29

Smart Contact Lenses for Healthcare Monitoring and Therapy DOI
Xiaohu Liu, Ying Ye, Yuancai Ge

и другие.

ACS Nano, Год журнала: 2024, Номер 18(9), С. 6817 - 6844

Опубликована: Фев. 26, 2024

The eye contains a wealth of physiological information and offers suitable environment for noninvasive monitoring diseases via smart contact lens sensors. Although extensive research efforts recently have been undertaken to develop sensors, they are still in an early stage being utilized as intelligent wearable sensing platform various biophysical/chemical conditions. In this review, we provide general introduction lenses that developed disease therapy. First, different biomarkers available from the ocular summarized, including both physical chemical biomarkers, followed by commonly used materials, manufacturing processes, characteristics lenses. Smart eye-drug delivery with advancing technologies achieve more efficient treatments then introduced well latest developments diagnosis. Finally, sensor communication antimicrobial other emerging bioapplications also discussed challenges prospects future development

Язык: Английский

Процитировано

26

Wireless Battery-free and Fully Implantable Organ Interfaces DOI
A. K. Bhatia, Jessica Hanna, Tucker Stuart

и другие.

Chemical Reviews, Год журнала: 2024, Номер 124(5), С. 2205 - 2280

Опубликована: Фев. 21, 2024

Advances in soft materials, miniaturized electronics, sensors, stimulators, radios, and battery-free power supplies are resulting a new generation of fully implantable organ interfaces that leverage volumetric reduction mechanics by eliminating electrochemical storage. This device class offers the ability to provide high-fidelity readouts physiological processes, enables stimulation, allows control over organs realize therapeutic diagnostic paradigms. Driven seamless integration with connected infrastructure, these devices enable personalized digital medicine. Key advances carefully designed material, electrophysical, electrochemical, electromagnetic systems form implantables mechanical properties closely matched target deliver functionality supports sensors stimulators. The elimination operation, anywhere from acute, lifetimes matching subject physical dimensions imperceptible operation. review provides comprehensive overview basic building blocks related topics such as implantation, delivery, sterilization, user acceptance. State art examples categorized system an outlook interconnection advanced strategies for computation leveraging consistent influx elevate this current battery-powered is highlighted.

Язык: Английский

Процитировано

17

Revolutionary Point‐of‐Care Wearable Diagnostics for Early Disease Detection and Biomarker Discovery through Intelligent Technologies DOI Creative Commons
Fatemeh Haghayegh,

Alireza Norouziazad,

Elnaz Haghani

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 3, 2024

Early-stage disease detection, particularly in Point-Of-Care (POC) wearable formats, assumes pivotal role advancing healthcare services and precision-medicine. Public benefits of early detection extend beyond cost-effectively promoting outcomes, to also include reducing the risk comorbid diseases. Technological advancements enabling POC biomarker recognition empower discovery new markers for various health conditions. Integration wearables with intelligent frameworks represents ground-breaking innovations automation operations, conducting advanced large-scale data analysis, generating predictive models, facilitating remote guided clinical decision-making. These substantially alleviate socioeconomic burdens, creating a paradigm shift diagnostics, revolutionizing medical assessments technology development. This review explores critical topics recent progress development 1) systems solutions physiological monitoring, as well 2) discussing current trends adoption smart technologies within settings developing biological assays, ultimately 3) exploring utilities platforms discovery. Additionally, translation from research labs broader applications. It addresses associated risks, biases, challenges widespread Artificial Intelligence (AI) integration diagnostics systems, while systematically outlining potential prospects, challenges, opportunities.

Язык: Английский

Процитировано

17