ACS Pharmacology & Translational Science,
Год журнала:
2022,
Номер
5(5), С. 278 - 298
Опубликована: Май 2, 2022
Achieving
synergism,
often
by
combination
therapy
via
codelivery
of
chemotherapeutic
agents,
remains
the
mainstay
treating
multidrug-resistance
cases
in
cancer
and
microbial
strains.
With
a
typical
core–shell
architecture
surface
functionalization
to
ensure
facilitated
targeting
tissues,
nanocarriers
are
emerging
as
promising
platform
toward
gaining
such
synergism.
Co-encapsulation
disparate
theranostic
agents
nanocarriers─from
molecules
imaging
or
photothermal
modalities─can
not
only
address
issue
protecting
labile
drug
payload
from
hostile
biochemical
environment
but
may
also
optimized
release
synergistic
effect.
However,
fate
co-encapsulated
molecules,
influenced
temporospatial
proximity,
unpredictable
marred
with
events
deleterious
impact
on
therapeutic
efficacy,
including
molecular
rearrangement,
aggregation,
denaturation.
Thus,
more
than
just
an
art
confining
multiple
therapeutics
into
3D
nanoscale
space,
nanocarrier,
while
aiming
for
should
strive
achieving
harmonious
cohabitation
encapsulated
that,
despite
proximity
opportunities
interaction,
remain
innocuous
each
other
integrity.
This
account
will
inspect
current
progress
co-encapsulation
distill
out
key
points
accomplishing
synergism
through
reciprocity.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
64(5), С. 1385 - 1402
Опубликована: Сен. 2, 2022
Freezing
is
commonly
used
to
extend
the
shelf
life
of
meat
and
products
but
may
impact
overall
quality
those
by
inducing
structural
changes
in
myofibrillar
proteins
(MPs)
through
denaturation,
chemical
modification,
encouraging
protein
aggregation.
This
review
covers
effect
freezing
on
denaturation
MPs
terms
effects
ice
crystallization
solute
concentrations,
cold
oxidation.
Freezing-induced
begins
with
extracellular
spaces
concentrations
unfrozen
water
fraction.
At
typical
temperatures
for
(lower
than
−18
°C),
occurs,
accompanied
an
alteration
their
secondary
tertiary
structure.
Moreover,
disruption
muscle
cells
triggers
release
cellular
enzymes,
accelerating
degradation
To
minimize
severe
deterioration
during
frozen
storage
meat,
there
a
vital
need
use
appropriate
temperature
below
glass
transition
avoid
fluctuations
prevent
recrystallization.
Such
understanding
MP
can
be
applied
determine
optimum
conditions
highly
retained
sensory,
nutritional,
functional
qualities.
Pharmaceutics,
Год журнала:
2022,
Номер
14(12), С. 2575 - 2575
Опубликована: Ноя. 23, 2022
Given
their
safety
and
efficiency
in
protecting
protein
integrity,
polysorbates
(PSs)
have
been
the
most
widely
used
excipients
for
stabilization
of
therapeutics
years.
In
recent
decades,
however,
there
numerous
reports
about
visible
or
sub-visible
particles
PS-containing
biotherapeutic
products,
which
is
a
major
quality
concern
parenteral
drugs.
Alternative
that
are
safe
administration,
efficient
different
drugs
against
various
stress
conditions,
effective
high-concentrated
liquid
formulations,
stable
under
storage
conditions
duration
product's
shelf-life,
compatible
with
other
formulation
components
primary
packaging
highly
sought
after.
The
aim
this
paper
to
review
potential
alternative
from
families,
including
surfactants,
carbohydrate-
amino
acid-based
excipients,
synthetic
amphiphilic
polymers,
ionic
liquids
enable
stabilization.
For
each
category,
important
characteristics
such
as
ability
stabilize
proteins
thermal
mechanical
stresses,
current
knowledge
related
profile
interactions
components,
debated.
Based
on
provided
information
detailed
discussion
thereof,
may
pave
way
identification
development
RSC Advances,
Год журнала:
2023,
Номер
13(51), С. 35947 - 35963
Опубликована: Янв. 1, 2023
Protein-based
therapeutics
have
revolutionized
the
pharmaceutical
industry
and
become
vital
components
in
development
of
future
therapeutics.
They
offer
several
advantages
over
traditional
small
molecule
drugs,
including
high
affinity,
potency
specificity,
while
demonstrating
low
toxicity
minimal
adverse
effects.
However,
manufacturing
processes
protein-based
presents
challenges
related
to
protein
folding,
purification,
stability
immunogenicity
that
should
be
addressed.
These
proteins,
like
other
biological
molecules,
are
prone
chemical
physical
instabilities.
The
drugs
throughout
entire
manufacturing,
storage
delivery
process
is
essential.
occurrence
structural
instability
resulting
from
misfolding,
unfolding,
modifications,
as
well
aggregation,
poses
a
significant
risk
efficacy
these
overshadowing
their
promising
attributes.
Gaining
insight
into
alterations
caused
by
aggregation
impact
on
for
advancement
refinement
Hence,
this
review,
we
discussed
some
features
during
production,
formulation
stabilization
strategies
engineering
computational
methods
prevent
aggregation.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
Abstract
Neurodegenerative
diseases,
particularly
Alzheimer's
disease
and
Parkinson's
disease,
present
formidable
challenges
in
modern
medicine
due
to
their
complex
pathologies
the
absence
of
curative
treatments.
Despite
advances
symptomatic
management,
early
diagnosis
remains
essential
for
mitigating
progression
improving
patient
outcomes.
Traditional
diagnostic
methods,
such
as
MRI,
PET,
cerebrospinal
fluid
biomarker
analysis,
are
often
inadequate
detection
these
diseases.
Emerging
porous
materials,
including
metal–organic
frameworks
(MOFs),
covalent–organic
(COFs),
MXene,
zeolites,
silicon,
offer
promising
new
approaches
neurodegenerative
These
characterized
by
highly
tunable
physicochemical
properties,
have
potential
capture
concentrate
disease‐specific
biomarkers
amyloid‐beta
(Aβ),
tau
protein,
alpha‐synuclein
(α‐Syn).
The
integration
materials
into
advanced
biosensors
real‐time
holds
promise
revolutionizing
neurodiagnostic,
enabling
non‐invasive,
sensitive,
specific
platforms.
Furthermore,
incorporation
artificial
intelligence
(AI)
machine
learning
(ML)
techniques
analysis
sensor
data
enhances
accuracy
allows
more
efficient
interpretation
profiles.
AI
ML
can
optimize
feature
selection,
improve
pattern
recognition,
facilitate
prediction
progression,
making
them
indispensable
tools
personalized
medicine.
This
review
explores
diagnostics,
emphasizing
design,
functionality,
synergistic
role
advancing
clinical
applications.
Polymers,
Год журнала:
2021,
Номер
13(24), С. 4327 - 4327
Опубликована: Дек. 10, 2021
Academic
research
regarding
polymeric
materials
has
been
of
great
interest.
Likewise,
polymer
industries
are
considered
as
the
most
familiar
petrochemical
industries.
Despite
valuable
and
continuous
advancements
in
various
material
technologies
over
last
century,
many
varieties
advances
related
to
field
science
engineering
still
promise
a
potential
for
exciting
new
applications.
Research,
development,
industrial
support
have
key
factors
behind
progress
This
work
provides
insight
into
recent
energy
applications
polymers,
including
storage
production.
The
study
enhanced
oil
recovery
water
treatment
will
be
presented
evaluated.
In
addition,
this
review,
we
wish
emphasize
importance
functional
polymers
effective
adsorbents
organic
pollutants
from
wastewater.
Furthermore,
biomedical
reviewed
discussed.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(21), С. 13428 - 13428
Опубликована: Ноя. 3, 2022
Inhibition
of
fibril
formation
is
considered
a
possible
treatment
strategy
for
amyloid-related
diseases.
Understanding
the
molecular
nature
inhibitor
action
crucial
design
drug
candidates.
In
present
review,
we
describe
common
kinetic
models
and
classify
known
inhibitors
by
mechanism
their
interactions
with
aggregating
protein
its
oligomers.
This
determines
step
or
steps
aggregation
process
that
become
inhibited
observed
changes
in
kinetics
equilibrium
formation.
The
results
numerous
studies
indicate
approaches
to
antiamyloid
discovery
include
search
strong
binders
monomers,
cappers
blocking
ends
growing
fibril,
species
absorbing
on
surface
oligomers
preventing
nucleation.
Strongly
binding
stabilizing
native
state
can
be
promising
structured
proteins
while
designing
candidates
targeting
disordered
challenging.
