Plant-based proteins from agro-industrial waste and by-products: Towards a more circular economy

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129576 - 129576

Published: Jan. 20, 2024

Language: Английский

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Freezing-induced denaturation of myofibrillar proteins in frozen meat

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 64(5), P. 1385 - 1402

Published: Sept. 2, 2022

Freezing is commonly used to extend the shelf life of meat and products but may impact overall quality those by inducing structural changes in myofibrillar proteins (MPs) through denaturation, chemical modification, encouraging protein aggregation. This review covers effect freezing on denaturation MPs terms effects ice crystallization solute concentrations, cold oxidation. Freezing-induced begins with extracellular spaces concentrations unfrozen water fraction. At typical temperatures for (lower than −18 °C), occurs, accompanied an alteration their secondary tertiary structure. Moreover, disruption muscle cells triggers release cellular enzymes, accelerating degradation To minimize severe deterioration during frozen storage meat, there a vital need use appropriate temperature below glass transition avoid fluctuations prevent recrystallization. Such understanding MP can be applied determine optimum conditions highly retained sensory, nutritional, functional qualities.

Language: Английский

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Stabilization challenges and aggregation in protein-based therapeutics in the pharmaceutical industry

RSC Advances, Journal Year: 2023, Volume and Issue: 13(51), P. 35947 - 35963

Published: Jan. 1, 2023

Protein-based therapeutics have revolutionized the pharmaceutical industry and become vital components in development of future therapeutics. They offer several advantages over traditional small molecule drugs, including high affinity, potency specificity, while demonstrating low toxicity minimal adverse effects. However, manufacturing processes protein-based presents challenges related to protein folding, purification, stability immunogenicity that should be addressed. These proteins, like other biological molecules, are prone chemical physical instabilities. The drugs throughout entire manufacturing, storage delivery process is essential. occurrence structural instability resulting from misfolding, unfolding, modifications, as well aggregation, poses a significant risk efficacy these overshadowing their promising attributes. Gaining insight into alterations caused by aggregation impact on for advancement refinement Hence, this review, we discussed some features during production, formulation stabilization strategies engineering computational methods prevent aggregation.

Language: Английский

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Formation mechanism and inhibition methods of frozen egg yolk gelation: A review

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 148, P. 104491 - 104491

Published: April 15, 2024

Language: Английский

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Recent advancements in the specific determination of carcinoembryonic antigens using MOF-based immunosensors

RSC Advances, Journal Year: 2024, Volume and Issue: 14(14), P. 9571 - 9586

Published: Jan. 1, 2024

Carcinoembryonic antigens (CEAs) are prominent cancer biomarkers that enable the early detection of numerous cancers.

Language: Английский

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Porous Materials for Early Diagnosis of Neurodegenerative Diseases

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract Neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease, present formidable challenges in modern medicine due to their complex pathologies the absence of curative treatments. Despite advances symptomatic management, early diagnosis remains essential for mitigating progression improving patient outcomes. Traditional diagnostic methods, such as MRI, PET, cerebrospinal fluid biomarker analysis, are often inadequate detection these diseases. Emerging porous materials, including metal–organic frameworks (MOFs), covalent–organic (COFs), MXene, zeolites, silicon, offer promising new approaches neurodegenerative These characterized by highly tunable physicochemical properties, have potential capture concentrate disease‐specific biomarkers amyloid‐beta (Aβ), tau protein, alpha‐synuclein (α‐Syn). The integration materials into advanced biosensors real‐time holds promise revolutionizing neurodiagnostic, enabling non‐invasive, sensitive, specific platforms. Furthermore, incorporation artificial intelligence (AI) machine learning (ML) techniques analysis sensor data enhances accuracy allows more efficient interpretation profiles. AI ML can optimize feature selection, improve pattern recognition, facilitate prediction progression, making them indispensable tools personalized medicine. This review explores diagnostics, emphasizing design, functionality, synergistic role advancing clinical applications.

Language: Английский

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Recent Advances in Functional Polymer Materials for Energy, Water, and Biomedical Applications: A Review

Polymers, Journal Year: 2021, Volume and Issue: 13(24), P. 4327 - 4327

Published: Dec. 10, 2021

Academic research regarding polymeric materials has been of great interest. Likewise, polymer industries are considered as the most familiar petrochemical industries. Despite valuable and continuous advancements in various material technologies over last century, many varieties advances related to field science engineering still promise a potential for exciting new applications. Research, development, industrial support have key factors behind progress This work provides insight into recent energy applications polymers, including storage production. The study enhanced oil recovery water treatment will be presented evaluated. In addition, this review, we wish emphasize importance functional polymers effective adsorbents organic pollutants from wastewater. Furthermore, biomedical reviewed discussed.

Language: Английский

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Alternative Excipients for Protein Stabilization in Protein Therapeutics: Overcoming the Limitations of Polysorbates

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(12), P. 2575 - 2575

Published: Nov. 23, 2022

Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been the most widely used excipients for stabilization of therapeutics years. In recent decades, however, there numerous reports about visible or sub-visible particles PS-containing biotherapeutic products, which is a major quality concern parenteral drugs. Alternative that are safe administration, efficient different drugs against various stress conditions, effective high-concentrated liquid formulations, stable under storage conditions duration product's shelf-life, compatible with other formulation components primary packaging highly sought after. The aim this paper to review potential alternative from families, including surfactants, carbohydrate- amino acid-based excipients, synthetic amphiphilic polymers, ionic liquids enable stabilization. For each category, important characteristics such as ability stabilize proteins thermal mechanical stresses, current knowledge related profile interactions components, debated. Based on provided information detailed discussion thereof, may pave way identification development

Language: Английский

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Enhancing encapsulation of curcumin by pH-driven and sodium alginate blending with ovalbumin as a carrier

Food Hydrocolloids, Journal Year: 2023, Volume and Issue: 149, P. 109623 - 109623

Published: Dec. 8, 2023

Language: Английский

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Molecular mechanism of high-pressure processing regulates the aggregation of major royal jelly proteins

Food Hydrocolloids, Journal Year: 2023, Volume and Issue: 144, P. 108928 - 108928

Published: June 10, 2023

Language: Английский

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