Chemical Communications,
Год журнала:
2022,
Номер
58(95), С. 13230 - 13233
Опубликована: Янв. 1, 2022
A
regioselective
Rh(III)-catalyzed
C-H
bond
naphthylation
and
cascade
directing
group
(DG)
transformation
has
been
realized
with
aryl
imidates
oxa
bicyclic
alkenes.
Diverse
naphthalene-substituted
aromatic
esters
were
synthesized
fruitfully.
The
DG
into
ester
endows
the
strategy
chances
of
further
functionalization
derivatization.
Preliminary
mechanistic
studies
demonstrate
that
carbonyl
oxygen
possibly
originates
from
corresponding
alkene.
Organic Letters,
Год журнала:
2022,
Номер
24(16), С. 3003 - 3008
Опубликована: Апрель 20, 2022
The
Rh-catalyzed
reactions
of
N-pyridinyl
enaminones
with
internal
alkynes
leading
to
the
synthesis
iminopyranes
via
a
key
C–H
bond
activation
and
subsequent
tautomeric
O–H
cleavage
are
reported.
Moreover,
pyridine
ring
in
amino
group
acts
as
an
auxiliary
monodentate
site
for
this
annulation
can
be
easily
removed
by
simple
hydrolysis
afford
pyranones.
Chemical Communications,
Год журнала:
2023,
Номер
59(27), С. 4036 - 4039
Опубликована: Янв. 1, 2023
The
synthesis
of
N-naphthyl
pyrazoles
has
been
realized
by
the
direct
three-component
reactions
enaminones,
aryl
hydrazine
hydrochlorides
and
internal
alkynes
via
Rh(III)
catalysis.
synthetic
employing
simple
substrates
lead
to
simultaneous
construction
dual
cyclic
moieties,
including
a
pyrazole
ring
phenyl
ring,
sequential
formation
two
C-N
three
C-C
bonds.
Organic Letters,
Год журнала:
2023,
Номер
25(39), С. 7214 - 7219
Опубликована: Сен. 26, 2023
A
novel
Rh(III)-catalyzed
cascade
alkenyl
C-H
activation/[3
+
2]
annulation/pinacol
rearrangement
reaction
of
enaminones
with
iodonium
ylides
has
been
developed.
This
methodology
provides
a
new
and
straightforward
synthetic
strategy
to
afford
highly
functionalized
2-spirocyclo-pyrrol-3-ones
in
satisfactory
yield
from
readily
available
starting
materials
under
mild
conditions.
Moreover,
gram-scale
reactions
further
derivatization
experiments
are
implemented
demonstrate
the
potential
utility
this
developed
approach.
Organic Letters,
Год журнала:
2022,
Номер
24(31), С. 5679 - 5683
Опубликована: Июль 28, 2022
Benzofuran
is
a
privileged
structure
in
many
bioactive
compounds;
however,
the
controlled
synthesis
of
C2,C3-nonsubstituted
benzofurans
has
been
scarce.
In
particular,
cumbersome
multistep
processes
are
inevitable
for
most
inaccessible
C4-substituted
isomers.
Herein,
we
report
Rh-catalyzed
direct
vinylene
annulation
readily
available
m-salicylic
acid
derivatives
with
carbonate
to
achieve
selective
construction
benzofurans.
The
Weinreb
amide
directing
group
facilitated
following
product
derivatization.
reaction
mechanism
was
investigated
by
DFT
calculations.
Organic Letters,
Год журнала:
2023,
Номер
25(18), С. 3206 - 3209
Опубликована: Май 4, 2023
Isoquinoline
is
a
privileged
structure
in
many
bioactive
compounds
and
valuable
ligands.
Transition-metal-catalyzed
oxidative
annulation
of
imine
derivatives
has
become
promising
synthetic
method;
however,
catalytic
synthesis
3,4-nonsubstituted
isoquinolines
by
formal
acetylene
been
scarce
to
date.
Herein,
we
introduce
vinyl
selenone
as
an
effective
surrogate
for
the
Rh-catalyzed
annulative
coupling
under
mild
conditions.
The
Se
fragment
can
be
recovered
diselenide
recycled.
product
readily
converted
1-aminoisoquinolines.
Chemical Communications,
Год журнала:
2022,
Номер
58(74), С. 10262 - 10289
Опубликована: Янв. 1, 2022
The
metal–carbon
bond
generated
through
C–H
activation
is
a
key
organometallic
intermediate,
which
could
be
further
functionalized
with
various
reacting
partners.
Among
the
coupling
partners
used
in
metal-catalysed
activation,
alkynes
occupy
prominent
position
on
account
of
their
varied
reactivity.
ACS Catalysis,
Год журнала:
2021,
Номер
11(18), С. 11579 - 11587
Опубликована: Сен. 3, 2021
Unique
reactivity
of
diphenylacetylene
has
been
uncovered
through
weak
chelation-assisted
cobalt-catalyzed
regioselective
C(4)–H
activation
3-pivolyl
indole.
α-Hydroxy
ketone
and
α,β-unsaturated
derivatives
have
synthesized
in
good
yields
from
indole
alkynes.
Notably,
the
C(4)–H-functionalized
product
was
obtained
with
high
stereo-
regioselectivity
simply
by
changing
coupling
partner
symmetrical
alkynes
to
unsymmetrical
aromatic-aliphatic
Most
importantly,
trifluoroethanol
acts
as
a
sole
source
water
for
this
conversion.
Quantitative
detection
bis(2,2,2-trifluoroethyl)
ether
dry
19F
NMR
LCMS
studies
indirectly
confirms
situ
formation
water.
A
six-membered
cobaltacycle
intermediate
detected
HRMS,
also,
further
confirmed
quantum
mechanical
calculations,
which
accounts
highly
functionalization.
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(8)
Опубликована: Июль 3, 2023
Abstract
Pyrrolo[1,2‐
α
]quinoxaline
and
its
derivatives
have
excellent
biological
activity
photoelectric
properties,
are
widely
used
in
the
fields
of
pharmaceutical
preparations
organic
electroluminescence.
This
review
starts
from
catalysts
summarizes
single
metal
catalysis
palladium,
rhodium,
iron,
molybdenum,
copper,
as
well
synergistic
iron
molybdenum
bimetallic
metal‐free
catalytic
systems
for
synthesis
pyrrolo[1,2‐
]quinoxaline.
The
mechanism
different
was
detailly
introduced
analysed.
By
analysing
advantages
disadvantages
existing
catalyst
systems,
prospects
new
methods
presented.
