European Journal of Organic Chemistry,
Год журнала:
2022,
Номер
2022(34)
Опубликована: Июль 29, 2022
Abstract
Herein,
a
method
for
N
‐aryl
amides
preparation
has
been
established
through
Rh(III)‐catalyzed
C(sp
2
)−N
cross‐coupling
reactions
of
alkyl
dioxazolones
with
arylboronic
acids,
heterocyclic
boronic
acid,
and
alkenyl
acid.
This
efficient
straightforward
catalytic
approach
was
featured
broad
substrate
scope
(38
examples),
good
functional
group
compatibility,
high
yields
(up
to
99
%),
is
suitable
late‐stage
modification
drug
molecular
structures.
The
possible
mechanism
hypothesis
also
accomplished.
Synthesis,
Год журнала:
2021,
Номер
54(06), С. 1621 - 1632
Опубликована: Окт. 23, 2021
Abstract
An
efficient
methodology
for
the
synthesis
of
dibenzo[a,c]carbazoles
via
annulation
2,3-diphenyl-1H-indoles
in
EtOH
under
UV
light
irradiation
(λ
=
365
nm)
along
with
hydrogen
evolution
is
described.
This
method
exhibits
advantages
mild
reaction
conditions,
no
requirement
any
oxidants
and
catalysts,
release
as
only
byproduct.
Notably,
mechanism
investigation
confirms
that
trans-4b,8a-dihydro-9H-dibenzo[a,c]carbazole
intermediate
could
convert
into
cis-4b,8a-dihydro-9H-dibenzo[a,c]carbazole,
which
relies
on
nitrogen
atom
indole
ring.
followed
by
intramolecular
dehydrogenation
yields
dibenzo[a,c]carbazoles.
European Journal of Organic Chemistry,
Год журнала:
2022,
Номер
2022(34)
Опубликована: Июль 29, 2022
Abstract
Herein,
a
method
for
N
‐aryl
amides
preparation
has
been
established
through
Rh(III)‐catalyzed
C(sp
2
)−N
cross‐coupling
reactions
of
alkyl
dioxazolones
with
arylboronic
acids,
heterocyclic
boronic
acid,
and
alkenyl
acid.
This
efficient
straightforward
catalytic
approach
was
featured
broad
substrate
scope
(38
examples),
good
functional
group
compatibility,
high
yields
(up
to
99
%),
is
suitable
late‐stage
modification
drug
molecular
structures.
The
possible
mechanism
hypothesis
also
accomplished.
