Molecules,
Год журнала:
2022,
Номер
27(17), С. 5382 - 5382
Опубликована: Авг. 24, 2022
In
this
paper,
detailed
comparisons
of
the
driving
force
in
thermodynamics
and
intrinsic
kinetics
1,2-dihydropyridine
1,4-dihydropyridine
isomers
PNAH,
HEH,
PYH
hydride
transfer
reactions
are
made.
For
1,2-PNAH
1,4-PNAH,
values
thermodynamic
forces,
kinetic
barriers,
thermo-kinetic
parameters
60.50
61.90
kcal/mol,
27.92
26.34
44.21
44.12
respectively.
1,2-HEH
1,4-HEH,
63.40
65.00
31.68
34.96
47.54
49.98
1,2-PYH
1,4-PYH,
order
69.90
72.60
33.06
25.74
51.48
49.17
It
is
not
difficult
to
find
that
thermodynamically
favorable
structures
necessarily
kinetically
favorable.
addition,
according
analysis
parameters,
1,2-HEH,
1,4-PYH
have
a
strong
hydride-donating
ability
actual
chemical
reactions.
Results in Chemistry,
Год журнала:
2024,
Номер
7, С. 101304 - 101304
Опубликована: Янв. 1, 2024
A
diverse
set
of
tetrahydrobenzofuran-4(2H)-one
derivative
4(a-o)
were
synthesized
using
a
one-pot
treatment
dimedone,
3-(1H-imidazol-1-yl)benzaldehyde,
and
different
phenacyl
bromide
by
utilizing
cesium
carbonate
as
cost-effective
catalyst
in
acetonitrile
under
mild
reaction
condition.
During
the
synthesis
compounds,
two
carbon–carbon
(C–C)
bonds
one
carbon–oxygen
(C–O)
bond
are
formed.
All
compounds
obtained
with
moderate
to
good
yield.
The
underwent
screening
assess
their
antimicrobial
antimalarial
properties.
Compounds
4
l
(117
µM)
4d
(145
exhibited
highest
potency
against
A.
baumannii
Car.
Resistant
P.
aeruginosa
comparison
standard
drug
chloramphenicol
(155
µM),
respectively.
Compound
(234
displayed
efficacy
C.
albicans
than
that
drug,
fluconazole
(327
while
4f
(1018
showed
greater
niger
griseofulvin
(1417
µM).
In
addition,
all
titled
activity.
Among
them,
(1.60
has
falciparum
quinine
(2.71
Since
compound
exhibits
strong
antibacterial
fungal
action
among
synthetics,
it
shows
remarkable
binding
affinities
−8.5
kcal
mol−1
−9.1
RSC Advances,
Год журнала:
2024,
Номер
14(13), С. 9300 - 9313
Опубликована: Янв. 1, 2024
Twenty-three
new
derivatives
of
(
R
/
S
)-TDHPM-5-carboxanilide
have
been
synthesized
with
up
to
99%
yield.
All
racemates
were
separated
using
chiral
HPLC
(Prep
LC)
which
provided
99.99%
purity.
AC
was
determined
circular
dichroism
spectra.
Annals of Medicine,
Год журнала:
2022,
Номер
54(1), С. 2548 - 2560
Опубликована: Сен. 18, 2022
A
series
of
N-(4-chlorophenyl)
substituted
pyrano[2,3-c]pyrazoles
was
synthesised
and
screened
for
their
potential
to
inhibit
kinases
exhibit
anticancer
activity
against
primary
patient-derived
glioblastoma
2D
cells
3D
neurospheres.
collection
10
compounds
evaluated
glioma
cell
lines,
with
compound
4j
exhibiting
promising
growth
inhibitory
properties.
Compound
139
purified
exhibited
low
micromolar
kinase
AKT2/PKBβ.
AKT
signalling
is
one
the
main
oncogenic
pathways
in
often
targeted
novel
therapeutics.
Indeed,
AKT2
levels
correlated
malignancy
poorer
patient
survival.
inhibited
neurosphere
formation
stem
potent
EC50
lines.
Although
potency
cells,
significantly
less
cytotoxicity
non-cancerous
even
at
fourfold–fivefold
concentration.
Herein
we
establish
a
biochemical
function
further
report
anti-glioma
vitro
first
time.KEY
MESSAGEAnti-glioma
pyrano[2,3-c]pyrazole
cells.
also
displayed
PKBβ/AKT2
activity.
nontoxic
towards
Archiv der Pharmazie,
Год журнала:
2021,
Номер
354(6)
Опубликована: Фев. 15, 2021
In
this
study,
we
report
on
antiproliferative
benzyloxy
dihydropyrimidinones
(DHPMs)
produced
by
the
Biginelli
reaction
of
benzaldehyde,
urea,
and
diverse
1,3-diones.
The
was
catalyzed
lanthanum
triflate
completed
within
1-1.5
h,
with
74-97%
yield.
assay
carried
out
for
all
synthesized
against
six
human
solid
tumor
cell
lines.
Six
compounds
showed
good
activity
GI50
values
below
5
μM.
Among
compounds,
most
potent
derivative
lines
in
range
1.1-3.1
These
DHPMs
comply
druglikeness.
Furthermore,
ADMET
prediction
effect
P-glycoprotein
were
also
studied.
Overall,
our
method
allows
eco-friendly
access
to
as
potential
anticancer
drugs.
Ultrasonics Sonochemistry,
Год журнала:
2021,
Номер
79, С. 105683 - 105683
Опубликована: Июль 27, 2021
The
pyrimidine
scaffold
is
present
in
many
bioactive
drugs;
therefore,
efficient
synthetic
routes
that
provide
shorter
reaction
times,
higher
yields,
and
site-selective
reactions
are
constantly
being
sought.
Ultrasound
(US)
irradiation
has
emerged
as
an
alternative
energy
source
the
synthesis
of
these
heterocyclic
scaffolds,
over
last
ten
years
there
been
a
significant
increase
number
publications
mentioning
US
either
construction
or
derivatization
core.
This
review
presents
detailed
summary
(with
140
references)
effects
(synergic
not)
on
core
through
classical
(e.g.,
multicomponent,
cyclocondensation,
cycloaddition,
alkylation
reactions).
main
points
were
taken
into
consideration
follows:
chemo-
regioselectivity
issues,
results
conventional
heating
methods
compared
to
mechanistic
insights
also
presented
discussed
for
key
reactions.
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(9)
Опубликована: Июль 29, 2023
Abstract
Multicomponent
reactions
(MCRs)
have
emerged
as
powerful
tools
in
synthetic
chemistry
for
the
efficient
synthesis
of
diverse
molecular
scaffolds,
particularly
nitrogen‐containing
heterocycles.
Despite
their
numerous
advantages,
use
transition
metal
catalysts
or
additives
MCRs
can
present
limitations
due
to
cost,
toxicity,
and
environmental
concerns.
In
recent
years,
there
has
been
a
growing
interest
metal‐free
N
‐heterocyclic
compounds.
This
review
provides
comprehensive
concise
overview
advancements
valuable
‐heterocycles
over
past
five
years.
The
is
systematically
organized,
categorizing
discussed
based
on
size
heterocyclic
ring
number
nitrogen
atoms.
Only
that
result
formation
rings
containing
at
least
one
atom
are
included,
while
derivatization
using
falls
outside
scope
this
review.
By
highlighting
developments
field,
aims
showcase
potential
significance
sustainable
strategies
accessing
elimination
metals
not
only
simplifies
reaction
conditions
but
also
contributes
greener
more
environmentally
friendly
approaches.
serves
resource
researchers
interested
design
application
