Chemical Science, Год журнала: 2020, Номер 12(4), С. 1295 - 1301
Опубликована: Ноя. 26, 2020
A hypoxia-tolerant photosensitizer FBC-based nanoplatform with strong NIR absorbance and ultra-high stability was facilely prepared for PDT of deep tumors.
Язык: Английский
Chemical Reviews, Год журнала: 2021, Номер 121(21), С. 13454 - 13619
Опубликована: Сен. 28, 2021
This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is photochemical-based treatment approach that involves the use of light combined with light-activated chemical, referred as PS. Attractively, PDT one alternatives conventional cancer due its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although concept photosensitizer-based photodynamic has been widely adopted clinical trials bioimaging, until now, our surprise, there no relevant article on rational designs organic PDT. Furthermore, most published articles focused nanomaterials nanotechnology based traditional PSs. Therefore, this aimed at reporting recent strategies develop innovative enhanced therapy, each example described detail instead providing only general overview, typically done previous reviews PDT, provide intuitive, vivid, specific insights readers.
Язык: Английский
Процитировано
1157
Chemical Society Reviews, Год журнала: 2022, Номер 51(12), С. 4996 - 5041
Опубликована: Янв. 1, 2022
This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.
Язык: Английский
Процитировано
280
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(21)
Опубликована: Фев. 21, 2023
Cancer is one of the deadliest diseases worldwide. Recent statistics have shown that metastases and tumor relapse are leading causes cancer-associated deaths. While traditional treatments able to efficiently remove primary tumor, secondary tumors remain poorly accessible. Capitalizing on this there an urgent need for novel treatment modalities. Among most promising approaches, increasing research interest has been devoted immunogenic cell death inducing agents trigger localized cancer cells as well induce immune response inside whole organism. Preliminary studies compounds could be overcome metastatic relapsing tumors. Herein, application metal complexes systematically reviewed.
Язык: Английский
Процитировано
115
Nature Communications, Год журнала: 2022, Номер 13(1)
Опубликована: Апрель 26, 2022
Abstract The limited therapeutic effect on hypoxic and refractory solid tumors has hindered the practical application of photodynamic therapy. Herein, we report our investigation an osmium-peroxo complex ( Os2 ), which is inactive in dark, but can release a peroxo ligand O 2 •− upon light irradiation even absence oxygen, transformed into cytotoxic osmium Os1 ). presence or tumors, behaving as chemotherapeutic drug. At same time, light-activated induces photocatalytic oxidation endogenous 1,4-dihydronicotinamide adenine dinucleotide living cancer cells, leading to ferroptosis, mediated by glutathione degradation, lipid peroxide accumulation down-regulation peroxidase 4. In vivo studies have confirmed that effectively inhibit growth mice. A promising strategy proposed for treatment with metal-based drugs.
Язык: Английский
Процитировано
88
Chemical Society Reviews, Год журнала: 2023, Номер 52(13), С. 4392 - 4442
Опубликована: Янв. 1, 2023
Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.
Язык: Английский
Процитировано
87
Coordination Chemistry Reviews, Год журнала: 2022, Номер 469, С. 214656 - 214656
Опубликована: Июнь 25, 2022
Язык: Английский
Процитировано
81
Chemical Reviews, Год журнала: 2023, Номер 123(16), С. 10135 - 10155
Опубликована: Авг. 3, 2023
Over the last few decades, various forms of regulated cell death (RCD) have been discovered and were found to improve cancer treatment. Although there are several reviews on RCD induced by photodynamic therapy (PDT), a comprehensive summary covering metal-based photosensitizers (PSs) as inducers has not yet presented. In this review, we systematically summarize works PSs that induce different types RCD, including ferroptosis, immunogenic (ICD), pyroptosis. The characteristics mechanisms each explained. At end section, reported commonalities between inducing same is emphasized, future perspectives novel discussed at review. Considering essential roles in therapy, hope review will provide stage for advances inducers.
Язык: Английский
Процитировано
81
Coordination Chemistry Reviews, Год журнала: 2022, Номер 461, С. 214495 - 214495
Опубликована: Март 12, 2022
Язык: Английский
Процитировано
75
Chemical Science, Год журнала: 2023, Номер 14(6), С. 1461 - 1471
Опубликована: Янв. 1, 2023
Conventional photodynamic therapy mainly causes a therapeutic effect on the primary tumor through localized generation of reactive oxygen species, while metastatic tumors remain poorly affected. Complementary immunotherapy is effective in eliminating small, non-localized distributed across multiple organs. Here, we report Ir(iii) complex Ir-pbt-Bpa as highly potent immunogenic cell death inducing photosensitizer for two-photon against melanoma. can produce singlet and superoxide anion radicals upon light irradiation, causing by combination ferroptosis death. In mouse model with two physically separated melanoma tumors, although only one was irradiated, strong reduction both observed. Upon not induced immune response CD8
Язык: Английский
Процитировано
66
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(20)
Опубликована: Март 14, 2023
Five osmium(II) polypyridyl complexes of the general formula [Os(4,7-diphenyl-1,10-phenanthroline)2 L]2+ were synthesized as photosensitizers for photodynamic therapy by varying nature ligand L. Thanks to pronounced π-extended structure ligands and heavy atom effect provided osmium center, these exhibit a high absorption in near-infrared (NIR) region (up 740 nm), unlike related ruthenium complexes. This led promising phototoxicity vitro against cancer cells cultured 2D cell layers but also multicellular tumor spheroids upon irradiation at nm. The complex (2,2'-bipyridine)]2+ was found be most efficient various lines, with indexes. Experiments on CT26 tumor-bearing BALB/c mice indicate that OsII could significantly reduce growth following nm laser irradiation. biological window this structurally simple makes it photosensitizer treatment.
Язык: Английский
Процитировано
45