Photoredox‐Promoted Co‐Production of Dihydroisoquinoline and H₂O₂ over Defective Zn₃In₂S₆

Advanced Materials, Год журнала: 2023, Номер 35(10)

Опубликована: Янв. 5, 2023

One of the most sustainable and promising approaches for hydrogen peroxide (H2 O2 ) production in a low-cost environment-friendly way is photosynthesis, which, however, suffers from poor carrier utilization low H2 productivity. The addition proton donors such as isopropanol or ethanol can increase production, unfortunately, will inevitably elevate entire cost while wasting oxidizing power holes (h+ ). Herein, tetrahydroisoquinolines (THIQs) employed distinctive donor thermodynamically feasible selective semi-dehydrogenation reaction to highly valuable dihydroisoquinolines (DHIQs), meanwhile, couple with promote generation one photoredox under photocatalysis by dual-functional Zn3 In2 S6 photocatalyst. Surprisingly, suitably defective offers an excellent near-stoichiometric co-production performance DHIQs at unprecedentedly high rates 66.4 62.1 mmol h-1 g-1 visible light (λ ≥ 400 nm), respectively, which outperforms all previously available reports even though sacrificial agents were those reports. Additionally, photocatalytic redox mechanism demonstrates that be generated through multiple pathways, highlighting synergistic effect among ROS (·O2- 1 ), h+ donor, has been ignored previous studies.

Язык: Английский

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Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms

Chemical Reviews, Год журнала: 2023, Номер 123(16), С. 10135 - 10155

Опубликована: Авг. 3, 2023

Over the last few decades, various forms of regulated cell death (RCD) have been discovered and were found to improve cancer treatment. Although there are several reviews on RCD induced by photodynamic therapy (PDT), a comprehensive summary covering metal-based photosensitizers (PSs) as inducers has not yet presented. In this review, we systematically summarize works PSs that induce different types RCD, including ferroptosis, immunogenic (ICD), pyroptosis. The characteristics mechanisms each explained. At end section, reported commonalities between inducing same is emphasized, future perspectives novel discussed at review. Considering essential roles in therapy, hope review will provide stage for advances inducers.

Язык: Английский

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Recent developments on other platinum metal complexes as target-specific anticancer therapeutics

Coordination Chemistry Reviews, Год журнала: 2023, Номер 490, С. 215231 - 215231

Опубликована: Май 19, 2023

Язык: Английский

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Recent Development of Copper‐Based Nanozymes for Biomedical Applications

Advanced Healthcare Materials, Год журнала: 2023, Номер 13(1)

Опубликована: Сен. 24, 2023

Copper (Cu), an indispensable trace element within the human body, serving as intrinsic constituent of numerous natural enzymes, carrying out vital biological functions. Furthermore, nanomaterials exhibiting enzyme-mimicking properties, commonly known nanozymes, possess distinct advantages over their enzyme counterparts, including cost-effectiveness, enhanced stability, and adjustable performance. These advantageous attributes have captivated attention researchers, inspiring them to devise various Cu-based nanomaterials, such copper oxide, Cu metal-organic framework, CuS, explore potential in enzymatic catalysis. This comprehensive review encapsulates most recent advancements illuminating applications realm biochemistry. Initially, it is delved into emulation typical types achieved by nanomaterials. Subsequently, latest breakthroughs concerning nanozymes biochemical sensing, bacterial inhibition, cancer therapy, neurodegenerative diseases treatment discussed. Within this segment, also explored modulation nanozyme activity. Finally, a visionary outlook for future development presented.

Язык: Английский

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Type I Photosensitizer Targeting G‐Quadruplex RNA Elicits Augmented Immunity for Cancer Ablation

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(17)

Опубликована: Март 1, 2023

Type I photodynamic therapy (PDT) represents a promising treatment modality for tumors with intrinsic hypoxia. However, type photosensitizers (PSs), especially ones near infrared (NIR) absorption, are limited and their efficacy needs improvement via new targeting tactics. We develop NIR PS by engineering acridinium derived donor-π-acceptor systems. The exhibits an exclusive PDT mechanism due to effective intersystem crossing disfavored energy transfer O2 , shows selective binding G-quadruplexes (G4s) hydrogen bonds identified molecular docking study. Moreover, it enables fluorogenic detection of G4s efficient ⋅- production in hypoxic conditions, leading immunogenic cell death substantial variations gene expression RNA sequencing. Our strategy demonstrates augmented antitumor immunity ablation cold tumor, highlighting its potential RNA-targeted precision cancer therapy.

Язык: Английский

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Progress and Challenges in Tumor Ferroptosis Treatment Strategies: A Comprehensive Review of Metal Complexes and Nanomedicine

Small, Год журнала: 2024, Номер 20(25)

Опубликована: Янв. 14, 2024

Abstract Ferroptosis is a new form of regulated cell death featuring iron‐dependent lipid peroxides accumulation to kill tumor cells. A growing body evidence has shown the potential ferroptosis‐based cancer therapy in eradicating refractory malignancies that are resistant apoptosis‐based conventional therapies. In recent years, studies have reported number ferroptosis inducers can increase vulnerability cells by regulating ferroptosis‐related signaling pathways. Encouraged rapid development ferroptosis‐driven therapies, interdisciplinary fields combine ferroptosis, pharmaceutical chemistry, and nanotechnology focused. First, prerequisites metabolic pathways for briefly introduced. Then, detail emerging designed boost ferroptosis‐induced therapy, including metal complexes, metal‐based nanoparticles, metal‐free nanoparticles summarized. Subsequently, application synergistic strategies with apoptosis other emphasis on use both cuproptosis induce redox dysregulation intracellular bimetallic copper/iron metabolism disorders during treatment discussed. Finally, challenges associated clinical translation future directions potentiating therapies highlighted.

Язык: Английский

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Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies

Chemical Science, Год журнала: 2024, Номер 15(31), С. 12234 - 12257

Опубликована: Янв. 1, 2024

Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently, great efforts have made improve the PDT effect in terms of safety efficiency. In this review, we highlight recent advances innovative strategies for enhanced PDT, including (1) development novel radicals, (2) design activatable photosensitizers based on TME light, (3) photocatalytic NADH oxidation damage mitochondrial electron transport chain. Additionally, new mechanisms are also presented an inspiration PSs. Finally, discuss current challenges future prospects clinical practice these strategies. It is hoped that review will provide angle understanding relationship between intratumoural redox environment mechanisms, ideas smart systems.

Язык: Английский

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Glial Perturbation in Metal Neurotoxicity: Implications for Brain Disorders

Neuroglia, Год журнала: 2025, Номер 6(1), С. 4 - 4

Опубликована: Янв. 6, 2025

Overexposure of humans to heavy metals and essential poses a significant risk for the development neurological neurodevelopmental disorders. The mechanisms through which these exert their effects include generation reactive oxygen species, mitochondrial dysfunction, activation inflammatory pathways, disruption cellular signaling. function glial cells in brain maintenance homeostasis cannot be overlooked. are particularly susceptible metal-induced neurotoxicity. Accumulation promotes microglial activation, triggering responses that can coincide with other neurotoxicity, inducing alteration synaptic transmission, cognitive deficit, neuronal damage. In this review, we highlighted role dysfunction some selected neurodegenerative diseases We further dive into how exposure such as nickel, manganese, methyl mercury, cadmium, iron, arsenic, lead affect functions microglia, astrocytes, oligodendrocytes they on relation Potential therapeutic interventions use new improved chelating agents antioxidant therapies might approach alleviating perturbations.

Язык: Английский

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Ferroptosis promotes sonodynamic therapy: a platinum(ii)–indocyanine sonosensitizer

Chemical Science, Год журнала: 2022, Номер 13(34), С. 9921 - 9926

Опубликована: Янв. 1, 2022

Sonodynamic therapy (SDT) has unique advantages in deep tumour ablation due to its penetration depth, showing great preclinical and clinical potential. Herein, a platinum(ii)-cyanine complex been designed investigate potential as SDT anticancer agent. It generates singlet oxygen (1O2) under ultrasound (US) irradiation or light irradiation, exhibits US-cytotoxicity breast cancer 4T1 cells but with negligible dark-cytotoxicity. Mechanistic investigations reveal that Pt-Cy reduces the cellular GSH GPX4, triggers cell ferroptosis US irradiation. The metabolomics analysis illustrates upon treatment significantly dysregulates glutathione metabolism, finally induces ferroptosis. In vivo studies further demonstrate inhibits tumor growth efficiency for is better than PDT vivo. This first example of platinum(ii) complexes sonodynamic therapy. work extends biological applications metal from SDT.

Язык: Английский

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A Photoactivated Sorafenib-Ruthenium(II) Prodrug for Resistant Hepatocellular Carcinoma Therapy through Ferroptosis and Purine Metabolism Disruption

Journal of Medicinal Chemistry, Год журнала: 2022, Номер 65(19), С. 13041 - 13051

Опубликована: Сен. 22, 2022

The curative effect of sorafenib in hepatocellular carcinoma (HCC) is limited and resistance remains a major obstacle for HCC. To overcome this obstacle, new photoactive sorafenib-Ru(II) complex Ru-Sora has been designed. Upon irradiation (λ = 465 nm), rapidly releases generates reactive oxygen species, which can oxidize intracellular substances such as GSH. Cellular experiments show that irradiated highly cytotoxic toward Hep-G2 cells, including sorafenib-resistant Hep-G2-SR cells. Compared to sorafenib, significant photoactivated chemotherapeutic against cancer cells 3D multicellular tumor spheroids. Furthermore, inducing apoptosis ferroptosis proved by GSH depletion, GPX4 downregulation, lipid peroxide accumulation. Metabolomics results suggest exerts photocytotoxicity disrupting the purine metabolism, expected inhibit development. This study provides promising strategy enhancing chemotherapy combating drug-resistant HCC disease.

Язык: Английский

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