Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 181, С. 114101 - 114101

Опубликована: Янв. 6, 2022

Язык: Английский

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Biomaterials as therapeutic drug carriers for inflammatory bowel disease treatment

Journal of Controlled Release, Год журнала: 2022, Номер 345, С. 1 - 19

Опубликована: Фев. 25, 2022

Язык: Английский

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Precision Nanotoxicology in Drug Development: Current Trends and Challenges in Safety and Toxicity Implications of Customized Multifunctional Nanocarriers for Drug-Delivery Applications

Pharmaceutics, Год журнала: 2022, Номер 14(11), С. 2463 - 2463

Опубликована: Ноя. 15, 2022

The dire need for the assessment of human and environmental endangerments nanoparticulate material has motivated formulation novel scientific tools techniques to detect, quantify, characterize these nanomaterials. Several paradigms possess enormous possibilities applications in many realms nanotoxicology. Furthermore, a large number cases, limited capabilities assess toxicological outcomes customized tailored multifunctional nanoparticles used drug delivery have hindered their full exploitation preclinical clinical settings. With ever-compounded availability materials commercialized settings, an ever-arising popular debate been egressing on whether social, human, costs associated with risks nanomaterials outweigh profits. Here we briefly review various health, pharmaceutical, regulatory aspects nanotoxicology engineered vitro vivo. issues encountered during safety toxicity assessments drug-delivery nanocarriers also summarized. recent trends implicated nanotoxicological evaluations matter vivo discussed. Due absence robust rigid guidelines, researchers currently frequently encounter larger challenges toxicology nanocarriers, which discussed here. Nanotoxicology appreciable significant part translational development as well commercialization potential nanocarriers; hence touched upon. Finally, brief overview provided regarding some nanocarrier-based medicines that are undergoing trials, those recently available patients. It is expected this will instigate interest research community working arena pharmaceutical nanoformulation-based delivery.

Язык: Английский

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Folic acid-modified lactoferrin nanoparticles coated with a laminarin layer loaded curcumin with dual-targeting for ulcerative colitis treatment

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 232, С. 123229 - 123229

Опубликована: Янв. 13, 2023

Язык: Английский

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Colon-targeted dual-coating MOF nanoparticles for the delivery of curcumin with anti-inflammatory properties in the treatment of ulcerative colitis

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 250, С. 114545 - 114545

Опубликована: Фев. 1, 2025

Язык: Английский

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Multifunctional chrysin-loaded gallic acid–glycerol monostearate conjugate-based injectable hydrogel for targeted inhibition of hypoxia-induced NLRP3 inflammasome in ulcerative colitis

Biomaterials Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Ulcerative colitis (UC) is a chronic inflammatory condition affecting the colon part of large intestine.

Язык: Английский

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Colon-Adhering Delivery System with Inflammation Responsiveness for Localized Therapy of Experimental Colitis

ACS Biomaterials Science & Engineering, Год журнала: 2023, Номер 9(8), С. 4781 - 4793

Опубликована: Июль 27, 2023

Ulcerative colitis (UC) is a chronic inflammation-related disease that severely affects the colon and rectum regions. A variety of therapy regimens are used for treatment UC. Clinically, therapeutic enema choice UC patients. Irrespective on-site administration, major limitation enemas dispossession medicine followed by low drug availability action. In our present work, we have developed an enzyme-responsive injectable hydrogel (ER-hydrogel) to overcome limitations enema. The hydrogels possess two advantages, which being exploited delivery in UC: prolonged retention enzyme responsiveness. former one prominent advantages compared free latter controls release or provides on-demand. ER-hydrogel was formulated heat-cool method purposes, corticosteroid drug, budesonide (Bud), encapsulated into evaluated its various physicochemical potentials dextran sodium sulfate (DSS)-induced vitro ex vivo adhesion studies confirm mucoadhesive nature ER-hydrogel, upsurge Bud from Bud-loaded upon addition esterase confirms enzyme-mediated ER-hydrogel. Moreover, exhibited promising results alleviating activity index UC, restored length colon, main hallmark terms health tissue, colonic tissue damage, as seen H&E-stained, AB-NR-stained, HID-AB-stained sections. Finally, also markedly subsided IL-1β, TNF-α, MPO, nitrite levels serum tissues. Thus, fabricated possesses appreciable translational potential due ability significantly ameliorate inflammatory changes naive water-based acute experimental mice.

Язык: Английский

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Leveraging thiol-functionalized biomucoadhesive hybrid nanoliposome for local therapy of ulcerative colitis

Biomaterials, Год журнала: 2024, Номер 312, С. 122747 - 122747

Опубликована: Авг. 6, 2024

Язык: Английский

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Oral chondroitin sulfate functionalized natural polyphenol for targeted therapy of ulcerative colitis

Materials & Design, Год журнала: 2024, Номер 238, С. 112645 - 112645

Опубликована: Янв. 6, 2024

Ulcerative colitis (UC) is an idiopathic, chronic, and progressive inflammatory set of conditions that affects the colonic mucosa. Natural Polyphenols are well documented for their excellent antioxidant properties have obvious advantages in strategy anti-oxidation treatment UC. However, poor water solubility, low bioavailability, unstable nature hindered clinical application. Therefore, we efficiently encapsulated bioactive polyphenol epigallocatechin gallate (EGCG) with poly(N-vinylpyrrolidone) (PVP) via reliable intermolecular hydrogen-bonded interactions, conjugated polysaccharide chondroitin sulfate (CS) gastrointestinal stability CD44 active targeting capability onto surfaces to achieve targeted delivery (EPC). The obtained EPC system showed average diameter 54 nm, monodisperse size distribution negatively charged surface. In vitro studies demonstrated reactive oxygen species (ROS)-scavenging anti-inflammatory ability system. After oral administration, localized inflamed colon effectively alleviated symptoms dextran sodium salt (DSS)-induced UC mice. Specifically, down-regulated expression cytokines, up-regulated tight junction-associated proteins restore intestinal barrier, modulated gut microbiota. This drug a simple self-assembling process may pave new polyphenol-based therapy

Язык: Английский

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Co-delivery of resveratrol and curcumin based on Mesona chinensis polysaccharides/zein nanoparticle for targeted alleviation of ulcerative colitis

Food Bioscience, Год журнала: 2024, Номер 59, С. 104060 - 104060

Опубликована: Апрель 10, 2024

Язык: Английский

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