Cyborg and Bionic Systems,
Год журнала:
2025,
Номер
6
Опубликована: Янв. 1, 2025
Soft
structures
driven
by
magnetic
fields
exhibit
the
characteristics
of
being
unencumbered
and
rapidly
responsive,
enabling
fabrication
various
soft
robots
according
to
specific
requirements.
However,
made
from
a
single
material
cannot
meet
multifunctional
demands
practical
scenarios,
necessitating
development
robot
technologies
with
composite
diverse
materials.
A
novel
enhanced
digital
light
processing
(DLP)
3-dimensional
(3D)
printing
technology
has
been
developed,
capable
different
materials
in
step.
Furthermore,
hard
material–superparamagnetic
was
designed
printed,
demonstrating
its
thermal
effect
under
high-frequency
editability
domains
material.
The
exhibits
range
locomotive
behaviors,
including
crawling,
rolling,
swimming.
Under
influence
1-Hz
actuation
field,
normalized
velocities
for
these
modes
motion
are
recorded
as
0.31
body
length
per
second
1.88
0.14
demonstrated
capacity
navigate
uneven
terrain,
surmount
barriers,
engage
directed
locomotion,
along
ability
capture
transport
objects.
Additionally,
it
showcased
swimming
capabilities
within
environments
characterized
low
Reynolds
numbers
high
fluid
viscosities,
findings
that
corroborate
simulation
analyses.
multimaterial
3D
introduced
this
research
presents
extensive
potential
design
manufacturing
robots.
Pharmaceutics,
Год журнала:
2023,
Номер
15(1), С. 236 - 236
Опубликована: Янв. 10, 2023
Despite
significant
advances
in
cancer
therapy
over
the
years,
its
complex
pathological
process
still
represents
a
major
health
challenge
when
seeking
effective
treatment
and
improved
healthcare.
With
advent
of
nanotechnologies,
nanomedicine-based
has
been
widely
explored
as
promising
technology
able
to
handle
requirements
clinical
sector.
Superparamagnetic
iron
oxide
nanoparticles
(SPION)
have
at
forefront
nanotechnology
development
since
mid-1990s,
thanks
their
former
role
contrast
agents
for
magnetic
resonance
imaging.
Though
use
MRI
probes
discontinued
due
an
unfavorable
cost/benefit
ratio,
several
innovative
applications
therapeutic
tools
prompted
renewal
interest.
The
unique
characteristics
SPION,
i.e.,
properties
enabling
specific
response
submitted
high
frequency
(magnetic
hyperthermia)
or
low
(magneto-mechanical
therapy)
alternating
field,
ability
generate
reactive
oxygen
species
(either
intrinsically
activated
using
various
stimuli),
make
them
particularly
adapted
therapy.
This
review
provides
comprehensive
description
fundamental
aspects
SPION
formulation
highlights
recent
approaches
regarding
vivo
field
Cancers,
Год журнала:
2024,
Номер
16(6), С. 1156 - 1156
Опубликована: Март 14, 2024
Hyperthermia
(HT)
is
an
anti-cancer
therapy
commonly
used
with
radio
and
chemotherapies
based
on
applying
heat
(39-45
°C)
to
inhibit
tumor
growth.
However,
controlling
towards
tumors
not
normal
tissues
challenging.
Therefore,
nanoparticles
(NPs)
are
in
HT
apply
only
induce
DNA
damage
the
expression
of
shock
proteins,
which
eventually
result
apoptosis.
The
aim
this
review
article
summarize
recent
advancements
use
magnetic
NPs
locally
increase
temperature
promote
cell
death.
In
addition,
development
nanocarriers
as
NP-based
drug
delivery
systems
discussed.
Finally,
efficacy
combined
chemotherapy,
radiotherapy,
gene
therapy,
photothermal
immunotherapy
explored.
Encyclopedia,
Год журнала:
2022,
Номер
2(4), С. 1811 - 1828
Опубликована: Ноя. 14, 2022
Magnetic
nanoparticles
(MNPs)
have
great
potential
in
various
areas
such
as
medicine,
cancer
therapy
and
diagnostics,
biosensing,
material
science.
In
particular,
magnetite
(Fe3O4)
are
extensively
used
for
numerous
bioapplications
due
to
their
biocompatibility,
high
saturation
magnetization,
chemical
stability,
large
surface
area,
easy
functionalization.
This
paper
describes
magnetic
nanoparticle
physical
biological
properties,
emphasizing
synthesis
approaches,
toxicity,
biomedical
applications,
focusing
on
the
most
recent
advancements
of
therapy,
theranostics,
separation,
biosensing.
Pharmaceutics,
Год журнала:
2022,
Номер
14(11), С. 2388 - 2388
Опубликована: Ноя. 5, 2022
Cancer
immunotherapy
has
tremendous
promise,
but
it
yet
to
be
clinically
applied
in
a
wider
variety
of
tumor
situations.
Many
therapeutic
combinations
are
envisaged
improve
their
effectiveness.
In
this
way,
strategies
capable
inducing
immunogenic
cell
death
(e.g.,
doxorubicin,
radiotherapy,
hyperthermia)
and
the
reprogramming
immunosuppressive
microenvironment
(TME)
M2-to-M1-like
macrophages
repolarization
tumor-associated
(TAMs))
particularly
appealing
enhance
efficacy
approved
immunotherapies
immune
checkpoint
inhibitors,
ICIs).
Due
modular
construction
versatility,
iron
oxide-based
nanomedicines
such
as
superparamagnetic
oxide
nanoparticles
(SPIONs)
can
combine
these
different
approaches
single
agent.
SPIONs
have
already
shown
safety
biocompatibility
possess
both
drug-delivery
chemotherapy,
ICIs)
magnetic
capabilities
hyperthermia
(MHT),
resonance
imaging).
review,
we
will
discuss
multiple
applications
cancer
immunotherapy,
focusing
on
theranostic
properties
target
TAMs
generate
MHT.
The
first
section
review
briefly
describe
targets
for
NPs.
following
sections
deal
with
overall
(including
MHT).
last
is
dedicated
SPION-induced
response
through
its
effects
ACS Omega,
Год журнала:
2024,
Номер
9(31), С. 33303 - 33334
Опубликована: Июль 25, 2024
The
increasing
occurrence
of
infectious
diseases
caused
by
antimicrobial
resistance
organisms
urged
the
necessity
to
develop
more
potent,
selective,
and
safe
agents.
unique
magnetic
tunable
properties
iron
oxide
nanoparticles
(IONPs)
make
them
a
promising
candidate
for
different
theragnostic
applications,
including
Though
IONPs
act
as
nonspecific
agent,
their
activities
are
directly
or
indirectly
linked
with
synthesis
methods,
synthesizing
precursors,
size,
shapes,
concentration,
surface
modifications.
Alteration
these
parameters
could
accelerate
decelerate
production
reactive
oxygen
species
(ROS).
An
increase
in
ROS
role
disrupts
bacterial
cell
walls,
membranes,
alters
major
biomolecules
(e.g.,
lipids,
proteins,
nucleic
acids),
affects
metabolic
processes
Krebs
cycle,
fatty
acid
synthesis,
ATP
glycolysis,
mitophagy).
In
this
review,
we
will
investigate
antibacterial
activity
bare
surface-modified
influence
physiochemical
on
activity.
Additionally,
report
potential
mechanism
IONPs'
action
driving
Nanoscale Horizons,
Год журнала:
2024,
Номер
9(3), С. 334 - 364
Опубликована: Янв. 1, 2024
Integrating
the
advances
of
emerging
hyperthermia
techniques
with
3D
tumor
models
and
non-invasive
temperature
control
systems
can
contribute
to
identifying
top-performing
hyperthermic
nanomedicines
in
preclinical
evaluation
stages.
Journal of Controlled Release,
Год журнала:
2024,
Номер
372, С. 751 - 777
Опубликована: Июль 4, 2024
Despite
significant
advances,
cancer
remains
a
leading
global
cause
of
death.
Current
therapies
often
fail
due
to
incomplete
tumor
removal
and
nonspecific
targeting,
spurring
interest
in
alternative
treatments.
Hyperthermia,
which
uses
elevated
temperatures
kill
cells
or
boost
their
sensitivity
radio/chemotherapy,
has
emerged
as
promising
alternative.
Recent
advancements
employ
nanoparticles
(NPs)
heat
mediators
for
selective
cell
destruction,
minimizing
damage
healthy
tissues.
This
approach,
known
NP
hyperthermia,
falls
into
two
categories:
photothermal
(PTT)
magnetothermal
(MTT).
PTT
utilizes
NPs
that
convert
light
heat,
while
MTT
magnetic
activated
by
alternating
fields
(AMF),
both
achieving
localized
damage.
These
methods
offer
advantages
like
precise
minimal
invasiveness,
reduced
systemic
toxicity.
However,
the
efficacy
hyperthermia
depends
on
many
factors,
particular,
properties,
microenvironment
(TME),
TME-NP
interactions.
Optimizing
this
treatment
requires
accurate
monitoring
strategies,
such
nanothermometry
biologically
relevant
screening
models
can
better
mimic
physiological
features
human
body.
review
explores
state-of-the-art
NP-mediated
discussing
available
nanomaterials,
strengths
weaknesses,
characterization
methods,
future
directions.
Our
particular
focus
lies
preclinical
techniques,
providing
an
updated
perspective
relevance
journey
towards
clinical
trials.
