Bioengineering,
Год журнала:
2024,
Номер
11(5), С. 508 - 508
Опубликована: Май 17, 2024
Magnesium
(Mg)
is
considered
an
attractive
option
for
orthopedic
applications
due
to
its
density
and
elastic
modulus
close
the
natural
bone
of
body,
as
well
biodegradability
good
tensile
strength.
However,
it
faces
serious
challenges,
including
a
high
degradation
rate
and,
result,
loss
mechanical
properties
during
long
periods
exposure
biological
environment.
Also,
among
other
weaknesses,
can
be
mentioned
that
does
not
deal
with
bacterial
biofilms.
It
has
been
found
making
composites
by
synergizing
various
components
efficient
way
improve
properties.
Among
metal
oxide
nanoparticles,
magnesium
nanoparticles
(MgO
NPs)
have
distinct
physicochemical
properties,
biocompatibility,
biodegradability,
bioactivity,
significant
antibacterial
which
make
choice
reinforcement
in
composites.
lack
comprehensive
understanding
effectiveness
Mg
NPs
matrix
reinforcements
mechanical,
corrosion,
fields
challenge
their
application.
While
introducing
role
MgO
medical
fields,
this
article
summarizes
most
important
results
recent
research
on
performance
Mg/MgO
ACS Nano,
Год журнала:
2023,
Номер
17(20), С. 20445 - 20461
Опубликована: Окт. 6, 2023
Radiotherapy
is
inevitably
accompanied
by
some
degree
of
radiation
resistance,
which
leads
to
local
recurrence
and
even
therapeutic
failure.
To
overcome
this
limitation,
herein,
we
report
the
room-temperature
synthesis
an
iodine-
ferrocene-loaded
covalent
organic
framework
(COF)
nanozyme,
termed
TADI-COF-Fc,
for
enhancement
radiotherapeutic
efficacy
in
treatment
radioresistant
esophageal
cancer.
The
iodine
atoms
on
COF
not
only
exerted
a
direct
effect
radiotherapy,
increasing
its
X-ray
absorption,
but
also
promoted
radiolysis
water,
increased
production
reactive
oxygen
species
(ROS).
In
addition,
ferrocene
surface
decoration
disrupted
redox
homeostasis
levels
hydroxyl
lipid
peroxide
radicals
depleting
intracellular
antioxidants.
Both
vitro
vivo
experiments
substantiated
excellent
response
TADI-COF-Fc.
This
study
demonstrates
potential
COF-based
multinanozymes
as
radiosensitizers
suggests
possible
integration
strategy
combination
oncotherapy.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(30)
Опубликована: Авг. 9, 2023
Developing
efficient
integrated
diagnosis
and
treatment
agents
based
on
fuel-free
self-movement
nanomotors
remains
challenging
in
antitumor
therapy.
In
this
study,
a
covalent
organic
framework
(COF)-based
biomimetic
nanomotor
composed
of
polypyrrole
(PPy)
core,
porphyrin-COF
shell,
HCT116
cancer
cell
membrane
coating
is
reported.
Under
near-infrared
(NIR)
light
irradiation,
the
obtained
mPPy@COF-Por
can
overcome
Brownian
motion
achieves
directional
through
self-thermophoretic
force
generated
from
PPy
core.
The
enables
to
selectively
recognize
source
lines
reduces
bio-adhesion
biological
medium,
endowing
with
NIR
light-powered
good
mobility.
More
importantly,
such
multifunctional
integration
allows
COF-based
be
powerful
nanoagent
for
treatment,
high
infrared
thermal
imaging/photoacoustic
imaging/fluorescence
trimodal
imaging-guided
combined
photothermal/photodynamic
therapeutic
effect
tumor
successfully
achieved.
results
offer
considerable
promise
development
COF
imaging/therapy
modalities
biomedical
applications.
Toxin Reviews,
Год журнала:
2024,
Номер
43(4), С. 513 - 539
Опубликована: Июль 2, 2024
Potentially
toxic
elements
(PTEs)
are
well-known
for
exposing
living
organisms
and
humans
to
different
levels
of
risk.
The
present
study
aimed
evaluate
the
extent
exposure
health
risks
sustained
by
inhabitants
suburbs
across
Southeastern
Nigeria
as
a
result
contaminated
water
sources.
There
existing
literatures
on
human
risk
assessment
in
region.
However,
this
is
first
report
detailed
breakdown
faced
nine
age
groups
area.
This
was
achieved
integrating
novel
code
(HERisk),
statistical
clustering,
quality
data.
Laboratory
analysis
showed
that
PTEs
(Fe2+,
Ni2+,
Cr3+,
Pb2+)
53.6%,
17.8%,
3.5%,
46%
samples
were
found
be
above
recommended
limits.
Aggregated
scores
ingestion
dermal
routes
revealed
children
aged
1
2
years
most
vulnerable
hazards.
According
cumulative
carcinogenic
values
(0.00E+00
2.41E-04),
proximal
regions
with
significant
activities
expose
locals
high
developing
cancer
via
ingestion.
Q-mode
hierarchical
cluster
successfully
validated
classification
schemes
used
interpretation
HERisk
values,
captured
patterns
dataset,
brought
forth
new
perspectives.
comprehensive
approach
can
adopted
framework
ongoing
monitoring
quality.
