Molecules,
Год журнала:
2023,
Номер
28(4), С. 1906 - 1906
Опубликована: Фев. 16, 2023
Cell
membrane
(CM)
is
a
phospholipid
bilayer
that
maintains
integrity
of
whole
cell
and
relates
to
many
physiological
pathological
processes.
Developing
CM
imaging
tools
feasible
method
for
visualizing
membrane-related
events.
In
recent
decades,
small-molecular
fluorescent
probes
in
the
near-infrared
(NIR)
region
have
been
pursued
extensively
staining
investigate
its
functions
related
this
review,
we
summarize
development
such
from
aspect
design
principles,
CM-targeting
mechanisms
biological
applications.
Moreover,
at
end
challenges
future
research
directions
designing
NIR
are
discussed.
This
review
indicates
more
efforts
required
activatable
probes,
easily
prepared
biocompatible
with
long
retention
time
regarding
CM,
super-resolution
monitoring
nanoscale
organization
multifunctional
phototherapy
effects.
Chemistry - An Asian Journal,
Год журнала:
2022,
Номер
17(10)
Опубликована: Март 28, 2022
Intracellular
bioactive
molecules
are
essential
for
the
maintenance
of
homeostasis
in
living
organisms.
Abnormal
levels
them
closely
related
to
occurrence
and
development
some
diseases.
Hence,
direct
accurate
visualization
these
is
vital
importance
exploring
their
pathological
roles.
However,
low-content,
short-lived,
widely
distributed
properties
impede
comprehensive
analysis
dramatically.
Fluorescence
photoacoustic
dual-mode
imaging
technology
provides
a
new
solution
above
issue.
Specifically,
combination
fluorescence
photoacoustic,
which
possesses
advantages
high
resolution
in-depth
tissue
analysis,
enables
more
systematic
exploration
pathogenic
mechanisms
molecules.
Moreover,
due
structural
tailorability
small
molecule
probes,
numerous
probes
have
been
developed
meet
demand
real-time
tracking
cells
or
vivo.
this
review,
we
briefly
summarize
key
advances
dual-modal
within
recent
years
(2015-2021).
A
particular
focus
placed
on
design
strategies
biological
applications
detection
various
Furthermore,
challenges
further
prospects
hot
field
highlighted.
Biomacromolecules,
Год журнала:
2022,
Номер
23(6), С. 2655 - 2666
Опубликована: Май 18, 2022
Owing
to
having
a
unique
mechanism
kill
cancer
cells
via
the
membrane
accumulation
of
lipid
peroxide
(LPO)
and
downregulation
glutathione
peroxidase-4
(GPX-4),
ferroptosis
therapy
(FT)
tumors
based
on
Fenton
reaction
iron
nanoparticles
has
been
receiving
much
attention
in
past
decade;
however,
there
are
some
hurdles
including
uncontrollable
release
ions,
slower
kinetics
intracellular
reaction,
poor
efficacy
FT
that
need
be
overcome.
Considering
cooperative
coordination
multivalent
thiol-pendant
polypeptide
ligand
with
we
put
forward
facile
strategy
for
constructing
iron-coordinated
nanohybrid
methacryloyloxyethyl
phosphorylcholine-grafted
polycysteine/iron
ions/tannic
acid
(i.e.,
PCFT),
which
could
deliver
higher
concentration
ions
into
cells.
The
dynamic
unsaturated
PCFT
is
favorable
stimuli-triggered
fast
realize
efficient
FT,
while
its
intrinsic
photothermia
would
boost
induce
synergistic
effect
between
photothermal
(PTT).
Both
immunofluorescence
analyses
reactive
oxygen
species
(ROS)
LPO
confirmed
resulted
during
process
greatly
boosted
ferroptosis,
Western
blot
assay
corroborated
expression
level
GPX-4
was
downregulated
by
highly
degraded
PTT-FT
vitro.
Excitingly,
single
intravenous
dose
plus
one
NIR
irradiation,
vivo
treatment
completely
eradicated
4T1
without
skin
scar
tumor
recurrence
16
days,
demonstrating
prominent
antitumor
efficacy,
as
evidenced
GPX-4,
H&E,
TUNEL
assays.
Chemical Communications,
Год журнала:
2023,
Номер
59(70), С. 10520 - 10523
Опубликована: Янв. 1, 2023
Carboxylesterase
(CE)
is
crucial
in
metabolizing
ester-containing
biomolecules
and
particularly
significant
liver
metabolic
diseases.
Herein,
we
present
the
first
activatable
NIRF/PA
dual-mode
imaging
probe
QHD-CE
for
detection
of
CE
vitro
vivo.
displays
excellent
sensitivity
selectivity
with
a
high
reaction
efficiency
(∼90
min).
By
utilizing
QHD-CE,
dynamic
changes
drug-induced
injury
diabetic
mice
models
were
monitored.
Analytical Chemistry,
Год журнала:
2023,
Номер
95(42), С. 15795 - 15802
Опубликована: Окт. 10, 2023
Lysosomes
are
one
of
the
important
organelles
within
cells,
and
their
dynamic
movement
processes
associated
with
many
biological
events.
Therefore,
real-time
monitoring
lysosomal
dynamics
has
far-reaching
implications.
A
lysosome-targeted
fluorescent
probe
N(CH2)3-BD-PZ
is
proposed
for
kinetic
motility.
Using
this
probe,
process
lysosomes
under
starvation
induction
was
successfully
explored
through
fluorescence
imaging.
Importantly,
we
observed
a
new
pattern
movement,
in
which
an
irregular
lysosome
slowly
cleaved
into
two
different-sized
touching
then
fused
to
form
round
lysosome.
This
research
provides
powerful
tool
understand
motility
intracellular
Molecules,
Год журнала:
2023,
Номер
28(4), С. 1906 - 1906
Опубликована: Фев. 16, 2023
Cell
membrane
(CM)
is
a
phospholipid
bilayer
that
maintains
integrity
of
whole
cell
and
relates
to
many
physiological
pathological
processes.
Developing
CM
imaging
tools
feasible
method
for
visualizing
membrane-related
events.
In
recent
decades,
small-molecular
fluorescent
probes
in
the
near-infrared
(NIR)
region
have
been
pursued
extensively
staining
investigate
its
functions
related
this
review,
we
summarize
development
such
from
aspect
design
principles,
CM-targeting
mechanisms
biological
applications.
Moreover,
at
end
challenges
future
research
directions
designing
NIR
are
discussed.
This
review
indicates
more
efforts
required
activatable
probes,
easily
prepared
biocompatible
with
long
retention
time
regarding
CM,
super-resolution
monitoring
nanoscale
organization
multifunctional
phototherapy
effects.
