Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 11, 2024
Abstract
Organic
agents
possessing
NIR‐II
and
photoacoustic
duplex
imaging
capabilities,
coupled
with
high‐efficiency
photothermal
conversion,
offer
significant
potential
for
noninvasive
precise
phototheranostics
of
glioblastoma,
which
is
further
augmented
when
these
can
concurrently
exhibit
tumor
targeting
blood–brain
barrier
(BBB)
permeability.
This
study
reports
a
series
finely
tunable
molecular
luminophores
based
on
the
aza‐BODIPY
scaffold,
featuring
unique
twisted
rotatable
structures.
They
are
constructed
to
folate‐decorated
polymeric
nanoparticles,
exhibiting
remarkable
NIR‐II/photoacoustic
performance
superior
conversion
efficiency
(49.7%).
Folate
modification
enables
BBB
permeability
through
receptor‐mediated
transcytosis,
allowing
efficient
phototherapy
in
4T1‐/glioblastoma‐bearing
mice
after
single
intravenous
injection
irradiation.
presents
rational
engineering
approach
versatile
structural
scaffold
designing
emitters
tailored
photophysical
properties
desirable
phototherapeutic
efficacy,
thereby
offering
novel
perspectives
development
advanced
depth
probes
brain
therapeutics.
Chemistry - An Asian Journal,
Journal Year:
2022,
Volume and Issue:
17(10)
Published: March 28, 2022
Intracellular
bioactive
molecules
are
essential
for
the
maintenance
of
homeostasis
in
living
organisms.
Abnormal
levels
them
closely
related
to
occurrence
and
development
some
diseases.
Hence,
direct
accurate
visualization
these
is
vital
importance
exploring
their
pathological
roles.
However,
low-content,
short-lived,
widely
distributed
properties
impede
comprehensive
analysis
dramatically.
Fluorescence
photoacoustic
dual-mode
imaging
technology
provides
a
new
solution
above
issue.
Specifically,
combination
fluorescence
photoacoustic,
which
possesses
advantages
high
resolution
in-depth
tissue
analysis,
enables
more
systematic
exploration
pathogenic
mechanisms
molecules.
Moreover,
due
structural
tailorability
small
molecule
probes,
numerous
probes
have
been
developed
meet
demand
real-time
tracking
cells
or
vivo.
this
review,
we
briefly
summarize
key
advances
dual-modal
within
recent
years
(2015-2021).
A
particular
focus
placed
on
design
strategies
biological
applications
detection
various
Furthermore,
challenges
further
prospects
hot
field
highlighted.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(4), P. 1906 - 1906
Published: Feb. 16, 2023
Cell
membrane
(CM)
is
a
phospholipid
bilayer
that
maintains
integrity
of
whole
cell
and
relates
to
many
physiological
pathological
processes.
Developing
CM
imaging
tools
feasible
method
for
visualizing
membrane-related
events.
In
recent
decades,
small-molecular
fluorescent
probes
in
the
near-infrared
(NIR)
region
have
been
pursued
extensively
staining
investigate
its
functions
related
this
review,
we
summarize
development
such
from
aspect
design
principles,
CM-targeting
mechanisms
biological
applications.
Moreover,
at
end
challenges
future
research
directions
designing
NIR
are
discussed.
This
review
indicates
more
efforts
required
activatable
probes,
easily
prepared
biocompatible
with
long
retention
time
regarding
CM,
super-resolution
monitoring
nanoscale
organization
multifunctional
phototherapy
effects.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(70), P. 10520 - 10523
Published: Jan. 1, 2023
Carboxylesterase
(CE)
is
crucial
in
metabolizing
ester-containing
biomolecules
and
particularly
significant
liver
metabolic
diseases.
Herein,
we
present
the
first
activatable
NIRF/PA
dual-mode
imaging
probe
QHD-CE
for
detection
of
CE
vitro
vivo.
displays
excellent
sensitivity
selectivity
with
a
high
reaction
efficiency
(∼90
min).
By
utilizing
QHD-CE,
dynamic
changes
drug-induced
injury
diabetic
mice
models
were
monitored.
Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
95(42), P. 15795 - 15802
Published: Oct. 10, 2023
Lysosomes
are
one
of
the
important
organelles
within
cells,
and
their
dynamic
movement
processes
associated
with
many
biological
events.
Therefore,
real-time
monitoring
lysosomal
dynamics
has
far-reaching
implications.
A
lysosome-targeted
fluorescent
probe
N(CH2)3-BD-PZ
is
proposed
for
kinetic
motility.
Using
this
probe,
process
lysosomes
under
starvation
induction
was
successfully
explored
through
fluorescence
imaging.
Importantly,
we
observed
a
new
pattern
movement,
in
which
an
irregular
lysosome
slowly
cleaved
into
two
different-sized
touching
then
fused
to
form
round
lysosome.
This
research
provides
powerful
tool
understand
motility
intracellular
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 11, 2024
Abstract
Organic
agents
possessing
NIR‐II
and
photoacoustic
duplex
imaging
capabilities,
coupled
with
high‐efficiency
photothermal
conversion,
offer
significant
potential
for
noninvasive
precise
phototheranostics
of
glioblastoma,
which
is
further
augmented
when
these
can
concurrently
exhibit
tumor
targeting
blood–brain
barrier
(BBB)
permeability.
This
study
reports
a
series
finely
tunable
molecular
luminophores
based
on
the
aza‐BODIPY
scaffold,
featuring
unique
twisted
rotatable
structures.
They
are
constructed
to
folate‐decorated
polymeric
nanoparticles,
exhibiting
remarkable
NIR‐II/photoacoustic
performance
superior
conversion
efficiency
(49.7%).
Folate
modification
enables
BBB
permeability
through
receptor‐mediated
transcytosis,
allowing
efficient
phototherapy
in
4T1‐/glioblastoma‐bearing
mice
after
single
intravenous
injection
irradiation.
presents
rational
engineering
approach
versatile
structural
scaffold
designing
emitters
tailored
photophysical
properties
desirable
phototherapeutic
efficacy,
thereby
offering
novel
perspectives
development
advanced
depth
probes
brain
therapeutics.
