Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 660 - 660
Опубликована: Фев. 16, 2023
Two
types
of
mesoporous
materials,
MCM-41
and
MCM-48,
were
functionalized
by
the
soft-template
method
using
(3-aminopropyl)triethoxysilane
(APTES)
as
a
modifying
agent.
The
obtained
silica
materials
loaded
with
trans-ferulic
acid
(FA).
In
order
to
establish
morphology
structure
series
specific
techniques
used
such
as:
X-ray
Diffraction
(XRD),
Scanning
Electron
Microscopy
(SEM),
Brunauer-Emmet-Teller
(BET),
Fourier
Transform
Infrared
Spectroscopy
(FTIR)
thermogravimetric
analysis
(TGA).
We
monitored
in
vitro
release
FA
at
two
different
pH
values,
simulated
gastric
fluid
(SGF)
intestinal
(SIF).
Additionally,
Staphylococcus
aureus
ATCC
25923,
Escherichia
coli
25922,
Pseudomonas
aeruginosa
27853
Candida
albicans
10231
evaluate
antimicrobial
activity
materials.
conclusion
can
be
employed
controlled
systems
for
polyphenols
extracted
from
natural
sources.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 1008 - 1008
Опубликована: Март 21, 2023
Several
developments
and
research
methods
are
ongoing
in
drug
technology
chemistry
to
elicit
effectiveness
regarding
the
therapeutic
activity
of
drugs
along
with
photoprotection
for
their
molecular
integrity.
The
detrimental
effect
UV
light
induces
damaged
cells
DNA,
which
leads
skin
cancer
other
phototoxic
effects.
application
sunscreen
shields
is
important,
recommended
filters.
Avobenzone
widely
used
as
a
UVA
filter
formulations.
However,
keto-enol
tautomerism
propagates
photodegradation
into
it,
further
channelizes
photoirradiation
effects,
limiting
its
use.
approaches
have
been
counter
these
issues,
including
encapsulation,
antioxidants,
photostabilizers,
quenchers.
To
seek
gold
standard
approach
photosensitive
drugs,
combinations
strategies
implemented
identify
effective
safe
agents.
stringent
regulatory
guidelines
formulations,
availability
limited
FDA-approved
filters,
led
many
researchers
develop
perfect
photostabilization
available
photostable
such
avobenzone.
From
this
perspective,
objective
current
review
summarize
recent
literature
on
delivery
avobenzone
that
could
be
useful
frame
industrially
oriented
potential
large
scale
circumvent
all
possible
photounstable
issues
ACS Nano,
Год журнала:
2023,
Номер
17(8), С. 7733 - 7749
Опубликована: Апрель 10, 2023
As
adjuvants
or
antigens,
bacterial
membranes
have
been
widely
used
in
recent
antibacterial
and
antitumor
research,
but
they
are
often
injected
multiple
times
to
achieve
therapeutic
outcomes,
with
limitations
biosafety
clinical
application.
Herein,
we
leverage
the
biocompatibility
immune
activation
capacity
of
Salmonella
strain
VNP20009
produce
double-layered
membrane
vesicles
(DMVs)
for
enhanced
systemic
safety
immunity.
Considering
photothermal
effect
polydopamine
upon
irradiation,
VNP20009-derived
DMVs
prepared
coat
surface
mesoporous
(MPD)
nanoparticles,
leading
potential
synergies
between
therapy
mediated
by
MPD
immunotherapy
magnified
DMVs.
The
single
dose
MPD@DMV
can
passively
target
tumors
activate
system
upregulated
T
cell
infiltration
secretion
levels
pro-inflammatory
factors
as
well
related
cytokines.
All
these
promoted
responses
result
malignant
melanoma
tumor
regression
extended
survival
time
on
local
distant
tumor-bearing
mouse
models.
Importantly,
further
explore
advantages
intravenous
injection
agent
compared
its
intratumoral
injection,
former
demonstrates
better
long-term
effects
animal
bodies.
Overall,
this
formulation
design
brings
broader
prospects
autologous
vaccine
adjuvant
cancer
therapy.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 365 - 365
Опубликована: Янв. 21, 2023
The
article
is
divided
into
several
sections,
focusing
on
extracellular
vesicles’
(EVs)
nature,
features,
commonly
employed
methodologies
and
strategies
for
their
isolation/preparation,
characterization/visualization.
This
work
aims
to
give
an
overview
of
advances
in
EVs’
extensive
nanomedical-drug
delivery
applications.
Furthermore,
considerations
EVs
translation
clinical
application
are
summarized
here,
before
the
review
a
special
kind
vesicles,
ones
derived
from
red
blood
cells
(RBCEVs).
Generally,
employing
as
drug
carriers
means
managing
entities
with
advantageous
properties
over
synthetic
vehicles
or
nanoparticles.
Besides
fact
that
certain
also
reveal
intrinsic
therapeutic
characteristics,
regenerative
medicine,
nanosize,
lipidomic
proteomic
profiles
enable
them
pass
biologic
barriers
display
cell/tissue
tropisms;
indeed,
engineering
can
further
optimize
organ
targeting.
In
second
part
review,
we
focus
our
attention
RBCEVs.
First,
describe
biogenesis
composition
those
naturally
produced
by
(RBCs)
under
physiological
pathological
conditions.
Afterwards,
discuss
current
procedures
isolate
and/or
produce
RBCEVs
lab
load
specific
cargo
exploitation.
Finally,
disclose
most
recent
applications
at
vitro
preclinical
research
level
potential
industrial
conclusion,
be,
near
future,
very
promising
versatile
platform
pharmaceutical
exploitations.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 660 - 660
Опубликована: Фев. 16, 2023
Two
types
of
mesoporous
materials,
MCM-41
and
MCM-48,
were
functionalized
by
the
soft-template
method
using
(3-aminopropyl)triethoxysilane
(APTES)
as
a
modifying
agent.
The
obtained
silica
materials
loaded
with
trans-ferulic
acid
(FA).
In
order
to
establish
morphology
structure
series
specific
techniques
used
such
as:
X-ray
Diffraction
(XRD),
Scanning
Electron
Microscopy
(SEM),
Brunauer-Emmet-Teller
(BET),
Fourier
Transform
Infrared
Spectroscopy
(FTIR)
thermogravimetric
analysis
(TGA).
We
monitored
in
vitro
release
FA
at
two
different
pH
values,
simulated
gastric
fluid
(SGF)
intestinal
(SIF).
Additionally,
Staphylococcus
aureus
ATCC
25923,
Escherichia
coli
25922,
Pseudomonas
aeruginosa
27853
Candida
albicans
10231
evaluate
antimicrobial
activity
materials.
conclusion
can
be
employed
controlled
systems
for
polyphenols
extracted
from
natural
sources.
