Pillararene-Based Supramolecular Polymers for Cancer Therapy

Molecules, Год журнала: 2023, Номер 28(3), С. 1470 - 1470

Опубликована: Фев. 3, 2023

Supramolecular polymers have attracted considerable interest due to their intriguing features and functions. The dynamic reversibility of noncovalent interactions endows supramolecular with tunable physicochemical properties, self-healing, externally stimulated responses. Among them, pillararene-based show great potential for biomedical applications fascinating host–guest easy modification. Herein, we summarize the state art cancer therapy illustrate its developmental trend future perspective.

Язык: Английский

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Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

Beilstein Journal of Nanotechnology, Год журнала: 2023, Номер 14, С. 218 - 232

Опубликована: Фев. 9, 2023

Cyclodextrins have been widely employed for drug delivery systems (DDSs) in which drugs are selectively delivered to a target site the body. Recent interest has focused on construction of cyclodextrin-based nanoarchitectures that show sophisticated DDS functions. These precisely fabricated based three important features cyclodextrins, namely (1) preorganized three-dimensional molecular structure nanometer size, (2) easy chemical modification introduce functional groups, and (3) formation dynamic inclusion complexes with various guests water. With use photoirradiation, released from at designated timing. Alternatively, therapeutic nucleic acids stably protected site. The efficient CRISPR-Cas9 system gene editing was also successful. Even more complicated can be designed DDSs. Cyclodextrin-based highly promising future applications medicine, pharmaceutics, other relevant fields.

Язык: Английский

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Octopus‐Inspired Adaptive Molecular Motion for Synergistic Photothermal and Nitric Oxide Antibacterial Therapy in Diabetic Wound Repair

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 1, 2024

Abstract Bacterial infections, especially those from drug‐resistant strains, pose a significant threat to healing diabetic skin injuries, with current treatments being intricated and often unsatisfactory. Inspired by octopuses, biomimetic material using α‐cyclodextrin (α‐CD) polyethylene glycol (PEG) assembled graphene oxide end‐capped polyrotaxanes (GO‐PR) is developed, where α‐CD mimics the flexible tentacles of an octopus. Further, cationically modified polyethyleneimine (PEI) resemble octopus suction cups, creating GO‐PRP, which effectively captures adheres bacteria. Importantly, emulate octopus's ink defense, GO‐PRP used as carrier for nitric (NO), resulting in GO‐PRP/NONOate. Utilizing photothermal conversion GO, near‐infrared light exposure triggers rapid heating NO release, providing efficient antibacterial activity biofilm dispersion, significantly reducing inflammation injuries type I rats. During wound healing, sustained release promotes vascular endothelial growth factor production blood vessel regeneration, enhancing collagen formation shortening time infections. Thus, octopus‐inspired GO‐PRP/NONOate emerges novel biomaterial treating bacterial infections wounds biomedical field.

Язык: Английский

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A universal electrochemical sensor for detection of nucleic acids and protein based on host-guest recognition of β-cyclodextrin polymer

Microchemical Journal, Год журнала: 2024, Номер 204, С. 110987 - 110987

Опубликована: Июнь 14, 2024

Язык: Английский

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Cyclodextrin Metal–Organic Framework Functionalized Carbon Materials with Optimized Interface Electronics and Selective Supramolecular Channels for High‐Performance Lithium–Sulfur Batteries

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

During the reaction process in lithium-sulfur batteries, Lewis acidic lithium polysulfides (LiPSs) affect ion distribution and overall electrolyte stability, degrading battery performance product (e.g., Li

Язык: Английский

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