Defects and Disorder in Covalent Organic Frameworks for Advanced Applications

Advanced Functional Materials, Год журнала: 2023, Номер 34(18)

Опубликована: Дек. 24, 2023

Abstract Crystalline porous organic polymers (CPPs) or covalent frameworks (COFs), are composed by light elements linked bonds. Despite the remarkable progress attained, there still bottlenecks limiting further development, some of them related to presence defects during their synthesis as well in‐depth understanding structure active centers and/or details reaction mechanism. Indeed, very often proposed structures far from reality because and disorders have not been considered. The present review provides an illustrative overview “defects disorder in COFs”. These include those only generated manipulation COFs, but also lack crystallinity, stacking network vacancies. starts giving general remarks on COFs synthetic methods, followed different methods play manage defects, how minimize take advantage gain new properties applications. Selected characterization techniques quantify defective sites presented. Finally, challenges future opportunities field summarized last section.

Язык: Английский

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Coordination directed metal covalent organic frameworks

Materials Chemistry Frontiers, Год журнала: 2023, Номер 7(15), С. 2995 - 3010

Опубликована: Янв. 1, 2023

The research on coordination directed metal covalent organic frameworks (MCOFs) is systematically reviewed for the continued development of this emerging field.

Язык: Английский

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Biomaterials Elicit Pyroptosis Enhancing Cancer Immunotherapy

Advanced Functional Materials, Год журнала: 2023, Номер 34(7)

Опубликована: Ноя. 5, 2023

Abstract Cancer immunotherapy has the potential to revolutionize treatment of malignant tumors, but its effectiveness is limited by low immune response rate and immune‐related adverse events. Pyroptosis, as an inflammatory programmed cell death type, triggers strong acute antitumor immunity, converting “cold” tumors “hot”. Particularly, biomaterials loading pyroptosis inducers targeting tumor microenvironment engineer pyroptosis, have achieved great progress in recent years. Herein, design strategy, mechanism pathway, role induce cancer are comprehensively reviewed. The present review focuses on application biomaterials‐induced immunotherapy, including nanogel, polymer prodrug, nanovesicle, mesoporous material. Additionally, synthesis a series stimuli‐responsive nanoplatforms, glutathione‐responsive, pH‐responsive, reactive oxygen species‐responsive, enzyme‐mimicking catalytic performance, described. Meanwhile, it augments multiple processes uptake, antigen presentation, T‐cell activation, expansion. Finally, perspectives pyroptosis‐mediated inflammation break through vascular basement membrane barrier achieving efficient volcanic penetration discussed. Artificial intelligence, multi‐omics analysis, anthropogenic animal models organoids presented, aiming provide guidance assistance for constructing effective controllable pyroptosis‐engineered improving immunotherapy.

Язык: Английский

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Metal-organic framework (MOF)/C-dots and covalent organic framework (COF)/C-dots hybrid nanocomposites: Fabrications and applications in sensing, medical, environmental, and energy sectors

Advances in Colloid and Interface Science, Год журнала: 2024, Номер 328, С. 103178 - 103178

Опубликована: Май 8, 2024

Язык: Английский

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Ligand Exchanges Among [N-I⁺-N] Halogen Bonds: A Robust Strategy for the Construction of Functional Halogen-Bonded Organic Frameworks (XOFs)

ACS Materials Letters, Год журнала: 2024, Номер 6(2), С. 508 - 516

Опубликована: Янв. 3, 2024

The development of diverse linking methods in organic framework materials is crucial for advancing science and engineering. [N-X+-N] halogen bonds are a powerful tool constructing supramolecular aggregates, including halogen-bonded frameworks (XOFs), which have emerged as new class frameworks. However, the existing production XOFs often yields insoluble AgI byproducts, impeding XOF crystallinity, performance, functionality. Hence, alternative preparation required. Here, we present novel approach to 2D via reversible ligand exchange reactions, avoiding unwanted byproducts enhancing crystallinity. Notably, this successfully highly crystalline XOF-TPTE, was unattainable with previous method. XOF-TPTE exhibits exceptional catalytic activity recyclability upon Pd(II) loading, showing remarkable selective performance Heck coupling reactions indicating its potential applications. This method broadens construction horizons expands their

Язык: Английский

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