Separation and Purification Technology, Год журнала: 2024, Номер unknown, С. 130640 - 130640
Опубликована: Ноя. 1, 2024
Язык: Английский
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 12, 2025
Ulcerative colitis (UC) is a chronic gastrointestinal inflammatory disorder with rising prevalence. Due to the recurrent and difficult-to-treat nature of UC symptoms, current pharmacological treatments fail meet patients' expectations. This study presents machine learning-assisted high-throughput screening strategy expedite discovery efficient nanozymes for treatment. Therapeutic requirements, including antioxidant property, acid stability, zeta potential, are quantified predicted by using learning model. Non-quantifiable attributes, intestinal barrier repair efficacy biosafety, assessed via screening. Feature significance analysis, sure independence screening, sparsifying operator symbolic regression reveal high-dimensional structure-activity relationships between material features therapeutic needs. SrDy
Язык: Английский
Процитировано
2
Advanced Fiber Materials, Год журнала: 2024, Номер unknown
Опубликована: Июнь 26, 2024
Язык: Английский
Процитировано
8
Chemical Society Reviews, Год журнала: 2024, Номер 53(18), С. 9059 - 9132
Опубликована: Янв. 1, 2024
Nanodrugs, which utilise nanomaterials in disease prevention and therapy, have attracted considerable interest since their initial conceptualisation the 1990s. Substantial efforts been made to develop nanodrugs for overcoming limitations of conventional drugs, such as low targeting efficacy, high dosage toxicity, potential drug resistance. Despite significant progress that has nanodrug discovery, precise design or screening with desired biomedical functions prior experimentation remains a challenge. This is particularly case regard personalised precision nanodrugs, require simultaneous optimisation structures, compositions, surface functionalities nanodrugs. The development powerful computer clusters algorithms it possible overcome this challenge through
Язык: Английский
Процитировано
8
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 156186 - 156186
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
6
Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(4), С. 100943 - 100943
Опубликована: Июль 14, 2024
Inflammatory bowel diseases (IBD) significantly contribute to high mortality globally and negatively affect patients' qualifications of life. The gastrointestinal tract has unique anatomical characteristics physiological environment limitations. Moreover, certain natural or synthetic anti-inflammatory drugs are associated with poor targeting, low drug accumulation at the lesion site, other side effects, hindering them from exerting their therapeutic effects. Colon-targeted delivery systems represent attractive alternatives as novel carriers for IBD treatment. This review mainly discusses treatment status IBD, obstacles delivery, design strategies colon-targeted systems, perspectives on existing complementary therapies. based recent reports, we summarized mechanism delivery. Finally, addressed challenges future directions facilitate exploitation advanced nanomedicine therapy.
Язык: Английский
Процитировано
5
The Chemical Record, Год журнала: 2025, Номер unknown
Опубликована: Март 12, 2025
Abstract Biomolecule‐engineered metal‐organic frameworks (Bio‐MOFs) are designed by incorporating biomolecules into or onto MOFs through covalent and non‐covalent interactions. These composite exhibit unique catalytic biological activities, making them highly suitable for various biocatalytic applications. In this review, we highlight recent advances in the material design, bioengineering methods, structural functional regulation techniques, applications of Bio‐MOFs. From a materials perspective, explore their structures multifunctional properties, including high surface area, tunable pore sizes, excellent biocompatibility. We also discuss techniques such as biomineralization post‐synthetic modification that employed synthesis. Furthermore, examine regulations Bio‐MOFs, which enhance activity stability interactions with enzymes, peptides, other biomolecules. Finally, analyze diverse reactions, biosensors/sensors, drug delivery, therapy, organic wastewater purification, emerging bio‐energy science. This review underscores pivotal role enhancing functions aims to inspire design synthesis novel Bio‐MOFs future bio‐related
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 8, 2025
Abstract For size‐sensitive catalytic reaction systems, precise control of geometric size heterogeneous transition metal catalysts, especially for non‐noble metals, is in desperate need and also a great challenge. Here, highly dispersed Ni nanoparticles (NPs) anchored within mesoporous silica (MS) fabricated through hybrid strategy amino‐modification vacuum‐impregnation. The NPs Ni/MS catalyst can be precisely regulated from 2.2 to 12.6 nm, causing variation the proportion low high coordination sites atoms. catalysts show volcanic trend between 2‐methoxy‐4‐methylphenol (MMP) yield geometry hydrodeoxygenation (HDO) bio‐derived vanillin, Ni/MS‐4.8 with middle (4.8 nm) shows optimal HDO performance highest MMP productivity 19.5 g −1 h . DFT calculation demonstrates that medium‐sized possesses abundant low/high coordinated atoms, wherein atoms facilitate adsorption H 2 promote dissociation activating C═O C─O bonds, thus displays superior reaction. This work paves way applicating catalysis.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 296, С. 139629 - 139629
Опубликована: Янв. 10, 2025
Язык: Английский
Процитировано
0
Environmental science and engineering, Год журнала: 2025, Номер unknown, С. 105 - 118
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
JACS Au, Год журнала: 2025, Номер unknown
Опубликована: Март 31, 2025
Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common cause of dementia. By 2050, number AD cases projected to exceed 131 million, placing significant strain on healthcare systems economies worldwide. The pathogenesis multifactorial, involving hypotheses/mechanisms, such as amyloid-β (Aβ) plaques, tau protein hyperphosphorylation, cholinergic neuron damage, oxidative stress, inflammation. Despite extensive research, complexity these potentially entangled mechanisms has hindered development treatments that can reverse progression. Nanotechnology, leveraging unique physical, electrical, magnetic, optical properties nanomaterials, emerged promising approach for treatment. In this Perspective, we first outlined major current pathogenic hypotheses then reviewed recent advances in nanomaterials addressing hypotheses. We have also discussed challenges translating into clinical applications proposed future directions, particularly multifunctional multitarget enhance their therapeutic efficacy applicability
Язык: Английский
Процитировано
0