Nanoassemblies Derived from Natural Flavonoid Compounds as New Antioxidant Oral Preparations for Targeted Inflammatory Bowel Disease Therapy DOI
Nan Tang, Zhen Ding, Siqi Zhang

и другие.

Advanced Functional Materials, Год журнала: 2023, Номер 33(45)

Опубликована: Июнь 26, 2023

Abstract Possessing the largest surface area of mucosa in body, gastrointestinal (GI) tract can easily sufferfrom inflammatory damage under various adverse external exposures, resulting occurrence bowel disease (IBD). Excessive reactive oxygen species (ROS) usually lead to local mucosal injury, accelerate formation niduses, andamplify and immune response. Antioxidant therapy, therefore, is considered as a potential strategy against IBDs. Herein, series novel dihydromyricetin‐based nanoassemblies with excellent antioxidant activities high dispersion GI oral preparations are developed for targeted IBD treatment. By changing raw materials, current be well extended preparation other insoluble natural flavonoid compound‐based nanoassemblies. The well‐designed dihydromyricetin‐PEG 1000‐based (DMY‐1000 NAs) stability great ROS scavenging capacity harsh environment hold an admirable capability toward intestinal inflamed lesions. Therefore, these biocompatible DMY‐1000 NAs show promising therapeutic effects typical IBDs including ulcerative colitis Crohn's murine models. This study not only provides new method constructing therapy platforms but also illustrates their prominent promise

Язык: Английский

Bioinspired polydopamine hydrogels: Strategies and applications DOI
Yuanting Xu, Junfei Hu, Jingjing Hu

и другие.

Progress in Polymer Science, Год журнала: 2023, Номер 146, С. 101740 - 101740

Опубликована: Сен. 17, 2023

Язык: Английский

Процитировано

122
A robust and 3D-printed solar evaporator based on naturally occurring molecules DOI
Xueqian Zhang, Yan Yu, Ning Li

и другие.

Science Bulletin, Год журнала: 2023, Номер 68(2), С. 203 - 213

Опубликована: Янв. 1, 2023

Язык: Английский

Процитировано

111
Programmed microalgae-gel promotes chronic wound healing in diabetes DOI Creative Commons
Yong Kang, Lingling Xu,

Jinrui Dong

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 3, 2024

Abstract Chronic diabetic wounds are at lifelong risk of developing foot ulcers owing to severe hypoxia, excessive reactive oxygen species (ROS), a complex inflammatory microenvironment, and the potential for bacterial infection. Here we develop programmed treatment strategy employing live Haematococcus (HEA). By modulating light intensity, HEA can be perform variety functions, such as antibacterial activity, supply, ROS scavenging, immune regulation, suggesting its use in therapy. Under high intensity (658 nm, 0.5 W/cm 2 ), green (GHEA) with efficient photothermal conversion mediate wound surface disinfection. decreasing 0.1 photosynthetic system GHEA continuously produce oxygen, effectively resolving problems hypoxia promoting vascular regeneration. Continuous irradiation induces astaxanthin (AST) accumulation cells, resulting gradual transformation from red hue (RHEA). RHEA scavenges excess ROS, enhances expression intracellular antioxidant enzymes, directs polarization M2 macrophages by secreting AST vesicles via exosomes. The living hydrogel sterilize enhance cell proliferation migration promote neoangiogenesis, which could improve infected healing female mice.

Язык: Английский

Процитировано

108
Advances in photothermal regulation strategies: from efficient solar heating to daytime passive cooling DOI
Liangliang Zhu, Liang Tian, Siyi Jiang

и другие.

Chemical Society Reviews, Год журнала: 2023, Номер 52(21), С. 7389 - 7460

Опубликована: Янв. 1, 2023

This review provides a comprehensive overview of photothermal regulation strategies from fundamentals, criteria, and advanced materials to emerging applications.

Язык: Английский

Процитировано

97
Robust and multifunctional natural polyphenolic composites for water remediation DOI
Yuanting Xu, Junfei Hu, Xueqian Zhang

и другие.

Materials Horizons, Год журнала: 2022, Номер 9(10), С. 2496 - 2517

Опубликована: Янв. 1, 2022

The scarcity of clean water has become a global environmental problem which constrains the development public health, economy, and sustainability. In recent years, natural polyphenols have drawn increasing interests as promising platforms towards diverse remediation composites devices, owing to their abundant renewable resource in nature, highly active surface chemistry, multifunctionality. This review aims summarize most advances highlights polyphenol-based composite materials (e.g., nanofibers, membranes, particles, hydrogels) for remediation, by focusing on structural functional features, well diversified applications including membrane filtration, solar distillation, adsorption, advanced oxidation processes, disinfection. Finally, future challenges this field are also prospected. It is anticipated that will provide new opportunities other kinds naturally occurring molecules purification applications.

Язык: Английский

Процитировано

87
A bioinspired antibacterial and photothermal membrane for stable and durable clean water remediation DOI

Yiyan Yang,

Lei Yang,

Fengying Yang

и другие.

Materials Horizons, Год журнала: 2022, Номер 10(1), С. 268 - 276

Опубликована: Ноя. 8, 2022

The tobramycin-doped polydopamine nanoparticles were developed to construct solar evaporator, which exhibited synergistic antibacterial behaviors and high water evaporation rate, thus achieving stable reuse even under microbe-rich environment.

Язык: Английский

Процитировано

86
A melanin-inspired robust aerogel for multifunctional water remediation DOI
Peng Yang,

Wanjie Bai,

Yuan Zou

и другие.

Materials Horizons, Год журнала: 2023, Номер 10(3), С. 1020 - 1029

Опубликована: Янв. 1, 2023

Solar-driven vapor generation has emerged as a promising wastewater remediation technology for clean water production. However, the complicated and diversified contaminants in still restrict its practical applications. Herein, inspired by melanin nature, robust aerogel was facilely fabricated multifunctional via one-pot condensation copolymerization of 5,6-dihydroxyindole formaldehyde. Benefiting from superhydrophilicity, underwater superoleophobicity, synergistic coordination effects, resulting not only showed excellent performances oil resistance oil-water separation ability, but also removed organic dyes heavy metal ions simultaneously. Moreover, owing to admirable light harvesting capacity porous microstructure fast transportation, aerogel-based evaporator exhibited an evaporation rate 1.42 kg m-2 h-1 with 91% efficiency under 1 sun illumination, which can be reused long-term evaporation. Note that such stable could maintained even containing complex multicomponent contaminants. Outdoor experiments lotus pond natural sunlight proved great potential All those features this all-in-one melanin-inspired may provide new strategies development photothermal devices solar-driven remediation.

Язык: Английский

Процитировано

77
Intervertebral disc degeneration and how it leads to low back pain DOI Creative Commons
Ashish D. Diwan, James Melrose

JOR Spine, Год журнала: 2022, Номер 6(1)

Опубликована: Ноя. 14, 2022

Abstract The purpose of this review was to evaluate data generated by animal models intervertebral disc (IVD) degeneration published in the last decade and show how has made invaluable contributions identification molecular events occurring contributing pain generation. IVD associated spinal is a complex multifactorial process, its complexity poses difficulties selection most appropriate therapeutic target focus on many potential candidates formulation strategies alleviate perception effect repair regeneration prevention neuropathic nociceptive pain. Nerve ingrowth increased numbers nociceptors mechanoreceptors degenerate are mechanically stimulated biomechanically incompetent abnormally loaded leading generation low back Maintenance healthy is, thus, an important preventative measure that warrants further investigation preclude Recent studies with growth differentiation factor 6 puncture multi‐level rat xenograft radiculopathy model have shown it considerable deterioration IVDs, regenerative properties promote recovery normal architectural functional organization inhibits inflammatory mediators lead Human clinical trials warranted eagerly anticipated compound assess efficacy treatment

Язык: Английский

Процитировано

76
Mimicking Antioxidases and Hyaluronan Synthase: A Zwitterionic Nanozyme for Photothermal Therapy of Osteoarthritis DOI Open Access
Peng Yu, Yanyan Li, Hui Sun

и другие.

Advanced Materials, Год журнала: 2023, Номер 35(44)

Опубликована: Июль 17, 2023

Abstract Restoring joint homeostasis is crucial for relieving osteoarthritis (OA). Current strategies are limited to unilateral efforts in lubrication, inhibition of inflammation, free radicals scavenging, and cartilage regeneration. Herein, by modifying molybdenum disulfide (MoS 2 ) with Mg 2+ ‐doped polydopamine coating polysulfobetaines, a dual‐bionic photothermal nanozyme (MPMP) constructed mimic antioxidases/hyaluronan synthase OA therapy. Photothermally enhanced lubrication lowers the coefficient friction (0.028) early stage treatment. The antioxidases‐mimicking properties MPMP contribute eliminating reactive oxygen nitrogen species (ROS/RNS) (over 90% scavenging ratio H O /·OH/O · – /DPPH/ABTS + supplying . With NIR irradiation, triggers thermogenesis (upregulating HSP70 expression) release, which promotes chondrogenesis inflammatory conditions deactivating NF‐κB/IL‐17 signaling pathways enhancing MAPK pathway. Benefiting from , MPMP‐NIR shows HAS‐mimicking activity increase intracellular (twofold) extracellular (3.12‐fold) HA production. Therefore, demonstrates superior spatiotemporally therapeutic effect on mice model, terms osteophytes (83.41% reduction), OARSI scores (88.57% ACAN expression (2.70‐fold increment). Hence, insights into nanozymes can be promising strategy therapy or other inflammation‐related diseases.

Язык: Английский

Процитировано

71
Robust and Multifunctional Nanoparticles Assembled from Natural Polyphenols and Metformin for Efficient Spinal Cord Regeneration DOI
Taoyang Yuan, Tianyou Wang, Jianhua Zhang

и другие.

ACS Nano, Год журнала: 2023, Номер 17(18), С. 18562 - 18575

Опубликована: Сен. 14, 2023

The treatment of spinal cord injury (SCI) remains unsatisfactory owing to the complex pathophysiological microenvironments at site and limited regenerative potential central nervous system. Metformin has been proven in clinical animal experiments repair damaged structures functions by promoting endogenous neurogenesis. However, early stage acute SCI, adverse microenvironment sites, such as reactive oxygen species inflammatory factor storm, can prevent activation neural stem cells (NSCs) differentiation NSCs into neurons, decreasing whole effect. To address those issues, a series robust multifunctional natural polyphenol-metformin nanoparticles (polyphenol-Met NPs) were fabricated with pH-responsiveness excellent antioxidative capacities. resulting NPs possessed several favorable advantages: First, composed active ingredients different biological properties, without need for carriers; second, feature could allow targeted drug delivery injured site; more importantly, enabled drugs performances exhibit strong synergistic effects. results demonstrated that improved polyphenols boosted activated neurons oligodendrocytes, which efficiently nerve enhance functional recovery SCI rats. This work highlighted design fabrication via efficient microenvironmental regulation activation.

Язык: Английский

Процитировано

49