Advanced Functional Materials,
Год журнала:
2023,
Номер
33(45)
Опубликована: Июнь 26, 2023
Abstract
Possessing
the
largest
surface
area
of
mucosa
in
body,
gastrointestinal
(GI)
tract
can
easily
sufferfrom
inflammatory
damage
under
various
adverse
external
exposures,
resulting
occurrence
bowel
disease
(IBD).
Excessive
reactive
oxygen
species
(ROS)
usually
lead
to
local
mucosal
injury,
accelerate
formation
niduses,
andamplify
and
immune
response.
Antioxidant
therapy,
therefore,
is
considered
as
a
potential
strategy
against
IBDs.
Herein,
series
novel
dihydromyricetin‐based
nanoassemblies
with
excellent
antioxidant
activities
high
dispersion
GI
oral
preparations
are
developed
for
targeted
IBD
treatment.
By
changing
raw
materials,
current
be
well
extended
preparation
other
insoluble
natural
flavonoid
compound‐based
nanoassemblies.
The
well‐designed
dihydromyricetin‐PEG
1000‐based
(DMY‐1000
NAs)
stability
great
ROS
scavenging
capacity
harsh
environment
hold
an
admirable
capability
toward
intestinal
inflamed
lesions.
Therefore,
these
biocompatible
DMY‐1000
NAs
show
promising
therapeutic
effects
typical
IBDs
including
ulcerative
colitis
Crohn's
murine
models.
This
study
not
only
provides
new
method
constructing
therapy
platforms
but
also
illustrates
their
prominent
promise
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Фев. 3, 2024
Abstract
Chronic
diabetic
wounds
are
at
lifelong
risk
of
developing
foot
ulcers
owing
to
severe
hypoxia,
excessive
reactive
oxygen
species
(ROS),
a
complex
inflammatory
microenvironment,
and
the
potential
for
bacterial
infection.
Here
we
develop
programmed
treatment
strategy
employing
live
Haematococcus
(HEA).
By
modulating
light
intensity,
HEA
can
be
perform
variety
functions,
such
as
antibacterial
activity,
supply,
ROS
scavenging,
immune
regulation,
suggesting
its
use
in
therapy.
Under
high
intensity
(658
nm,
0.5
W/cm
2
),
green
(GHEA)
with
efficient
photothermal
conversion
mediate
wound
surface
disinfection.
decreasing
0.1
photosynthetic
system
GHEA
continuously
produce
oxygen,
effectively
resolving
problems
hypoxia
promoting
vascular
regeneration.
Continuous
irradiation
induces
astaxanthin
(AST)
accumulation
cells,
resulting
gradual
transformation
from
red
hue
(RHEA).
RHEA
scavenges
excess
ROS,
enhances
expression
intracellular
antioxidant
enzymes,
directs
polarization
M2
macrophages
by
secreting
AST
vesicles
via
exosomes.
The
living
hydrogel
sterilize
enhance
cell
proliferation
migration
promote
neoangiogenesis,
which
could
improve
infected
healing
female
mice.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(21), С. 7389 - 7460
Опубликована: Янв. 1, 2023
This
review
provides
a
comprehensive
overview
of
photothermal
regulation
strategies
from
fundamentals,
criteria,
and
advanced
materials
to
emerging
applications.
Materials Horizons,
Год журнала:
2022,
Номер
9(10), С. 2496 - 2517
Опубликована: Янв. 1, 2022
The
scarcity
of
clean
water
has
become
a
global
environmental
problem
which
constrains
the
development
public
health,
economy,
and
sustainability.
In
recent
years,
natural
polyphenols
have
drawn
increasing
interests
as
promising
platforms
towards
diverse
remediation
composites
devices,
owing
to
their
abundant
renewable
resource
in
nature,
highly
active
surface
chemistry,
multifunctionality.
This
review
aims
summarize
most
advances
highlights
polyphenol-based
composite
materials
(e.g.,
nanofibers,
membranes,
particles,
hydrogels)
for
remediation,
by
focusing
on
structural
functional
features,
well
diversified
applications
including
membrane
filtration,
solar
distillation,
adsorption,
advanced
oxidation
processes,
disinfection.
Finally,
future
challenges
this
field
are
also
prospected.
It
is
anticipated
that
will
provide
new
opportunities
other
kinds
naturally
occurring
molecules
purification
applications.
Materials Horizons,
Год журнала:
2022,
Номер
10(1), С. 268 - 276
Опубликована: Ноя. 8, 2022
The
tobramycin-doped
polydopamine
nanoparticles
were
developed
to
construct
solar
evaporator,
which
exhibited
synergistic
antibacterial
behaviors
and
high
water
evaporation
rate,
thus
achieving
stable
reuse
even
under
microbe-rich
environment.
Materials Horizons,
Год журнала:
2023,
Номер
10(3), С. 1020 - 1029
Опубликована: Янв. 1, 2023
Solar-driven
vapor
generation
has
emerged
as
a
promising
wastewater
remediation
technology
for
clean
water
production.
However,
the
complicated
and
diversified
contaminants
in
still
restrict
its
practical
applications.
Herein,
inspired
by
melanin
nature,
robust
aerogel
was
facilely
fabricated
multifunctional
via
one-pot
condensation
copolymerization
of
5,6-dihydroxyindole
formaldehyde.
Benefiting
from
superhydrophilicity,
underwater
superoleophobicity,
synergistic
coordination
effects,
resulting
not
only
showed
excellent
performances
oil
resistance
oil-water
separation
ability,
but
also
removed
organic
dyes
heavy
metal
ions
simultaneously.
Moreover,
owing
to
admirable
light
harvesting
capacity
porous
microstructure
fast
transportation,
aerogel-based
evaporator
exhibited
an
evaporation
rate
1.42
kg
m-2
h-1
with
91%
efficiency
under
1
sun
illumination,
which
can
be
reused
long-term
evaporation.
Note
that
such
stable
could
maintained
even
containing
complex
multicomponent
contaminants.
Outdoor
experiments
lotus
pond
natural
sunlight
proved
great
potential
All
those
features
this
all-in-one
melanin-inspired
may
provide
new
strategies
development
photothermal
devices
solar-driven
remediation.
Abstract
The
purpose
of
this
review
was
to
evaluate
data
generated
by
animal
models
intervertebral
disc
(IVD)
degeneration
published
in
the
last
decade
and
show
how
has
made
invaluable
contributions
identification
molecular
events
occurring
contributing
pain
generation.
IVD
associated
spinal
is
a
complex
multifactorial
process,
its
complexity
poses
difficulties
selection
most
appropriate
therapeutic
target
focus
on
many
potential
candidates
formulation
strategies
alleviate
perception
effect
repair
regeneration
prevention
neuropathic
nociceptive
pain.
Nerve
ingrowth
increased
numbers
nociceptors
mechanoreceptors
degenerate
are
mechanically
stimulated
biomechanically
incompetent
abnormally
loaded
leading
generation
low
back
Maintenance
healthy
is,
thus,
an
important
preventative
measure
that
warrants
further
investigation
preclude
Recent
studies
with
growth
differentiation
factor
6
puncture
multi‐level
rat
xenograft
radiculopathy
model
have
shown
it
considerable
deterioration
IVDs,
regenerative
properties
promote
recovery
normal
architectural
functional
organization
inhibits
inflammatory
mediators
lead
Human
clinical
trials
warranted
eagerly
anticipated
compound
assess
efficacy
treatment
ACS Nano,
Год журнала:
2023,
Номер
17(18), С. 18562 - 18575
Опубликована: Сен. 14, 2023
The
treatment
of
spinal
cord
injury
(SCI)
remains
unsatisfactory
owing
to
the
complex
pathophysiological
microenvironments
at
site
and
limited
regenerative
potential
central
nervous
system.
Metformin
has
been
proven
in
clinical
animal
experiments
repair
damaged
structures
functions
by
promoting
endogenous
neurogenesis.
However,
early
stage
acute
SCI,
adverse
microenvironment
sites,
such
as
reactive
oxygen
species
inflammatory
factor
storm,
can
prevent
activation
neural
stem
cells
(NSCs)
differentiation
NSCs
into
neurons,
decreasing
whole
effect.
To
address
those
issues,
a
series
robust
multifunctional
natural
polyphenol-metformin
nanoparticles
(polyphenol-Met
NPs)
were
fabricated
with
pH-responsiveness
excellent
antioxidative
capacities.
resulting
NPs
possessed
several
favorable
advantages:
First,
composed
active
ingredients
different
biological
properties,
without
need
for
carriers;
second,
feature
could
allow
targeted
drug
delivery
injured
site;
more
importantly,
enabled
drugs
performances
exhibit
strong
synergistic
effects.
results
demonstrated
that
improved
polyphenols
boosted
activated
neurons
oligodendrocytes,
which
efficiently
nerve
enhance
functional
recovery
SCI
rats.
This
work
highlighted
design
fabrication
via
efficient
microenvironmental
regulation
activation.