An Immunoregulation Hydrogel with Controlled Hyperthermia‐Augmented Oxygenation and ROS Scavenging for Treating Diabetic Foot Ulcers

Advanced Functional Materials, Год журнала: 2024, Номер 34(33)

Опубликована: Май 6, 2024

Abstract Diabetic foot ulcers (DFUs), a serious and increasingly common chronic issue among diabetics, often do not respond well to generalized treatment strategies. Hypoxia the overexpression of reactive oxygen species (ROS), resulting in inflammatory dysregulation subsequent imbalance macrophage phenotypes, are critical factors contributing prolonged non‐healing DFU wounds. These two issues interact continuous, problematic cycle. Presently, there is lack comprehensive strategies aimed at addressing both these simultaneously interrupt this detrimental Herein, an immunomodulatory hydrogel (PHG2) developed for reshaping hostile microenvironment. The engineered PHG2 only removes excess internally‐produced ROS but also generates O 2 , with its efficiency further boosted by local hyperthermia (42.5 °C) activated near‐infrared light. Through vitro vivo studies, along transcriptomic assessment, it confirmed that disrupts feedback loop between inflammation while lowering M1/M2 ratio. Such discoveries contribute significant enhancement healing process injuries undergo gradual increase movement, covering wounds from back, mouth, foot. Ultimately, method provides easy, safe, highly effective solution treating DFUs.

Язык: Английский

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Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies

Advanced Functional Materials, Год журнала: 2024, Номер 34(38)

Опубликована: Апрель 23, 2024

Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.

Язык: Английский

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Immunomodulatory gallium/glycyrrhizic acid hydrogels for treating multidrug-resistant Pseudomonas aeruginosa-infected pressure ulcers

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150756 - 150756

Опубликована: Март 26, 2024

Язык: Английский

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In Situ Reaction-Generated Aldehyde-Scavenging Polypeptides-Curcumin Conjugate Nanoassemblies for Combined Treatment of Spinal Cord Injury

ACS Nano, Год журнала: 2024, Номер 18(10), С. 7346 - 7362

Опубликована: Фев. 28, 2024

The microenvironment after traumatic spinal cord injury (SCI) involves complex pathological processes, including elevated oxidative stress, accumulated reactive aldehydes from lipid peroxidation, excessive immune cell infiltration, etc. Unfortunately, most of current neuroprotection therapies cannot cope with the intricate pathophysiology SCI, leading to scant treatment efficacies. Here, we developed a facile in situ reaction-induced self-assembly method prepare aldehyde-scavenging polypeptides (PAH)-curcumin conjugate nanoassemblies (named as PFCN) for combined SCI. prepared PFCN could release PAH and curcumin response acidic SCI microenvironment. Subsequently, exhibited an effectively neuroprotective effect through scavenging toxic well nitrogen oxygen species neurons, modulating microglial M1/M2 polarization, down-regulating expression inflammation-related cytokines inhibit neuroinflammation. intravenous administration significantly ameliorate malignant injured cord, protect promote motor function recovery contusive rat model.

Язык: Английский

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An Antibiotic Nanobomb Constructed from pH‐Responsive Chemical Bonds in Metal‐Phenolic Network Nanoparticles for Biofilm Eradication and Corneal Ulcer Healing

Advanced Science, Год журнала: 2024, Номер 11(22)

Опубликована: Март 15, 2024

In the treatment of refractory corneal ulcers caused by Pseudomonas aeruginosa, antibacterial drugs delivery faces drawbacks low permeability and short ocular surface retention time. Hence, novel positively-charged modular nanoparticles (NPs) are developed to load tobramycin (TOB) through a one-step self-assembly method based on metal-phenolic network Schiff base reaction using 3,4,5-trihydroxybenzaldehyde (THBA), ε-poly-ʟ-lysine (EPL), Cu

Язык: Английский

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Bio-inspired and Multifunctional Polyphenol-Coated Textiles

Advanced Fiber Materials, Год журнала: 2024, Номер 6(4), С. 952 - 977

Опубликована: Апрель 11, 2024

Язык: Английский

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Two Birds with One Stone: Guanidyl Carbon Dots with Enhanced Antioxidative and Lipolytic Functions in Metabolic Associated Fatty Liver

Advanced Functional Materials, Год журнала: 2024, Номер 34(45)

Опубликована: Авг. 21, 2024

Abstract Metabolic‐associated fatty liver disease (MAFLD) has become one of the most widespread metabolic diseases nowadays, while no definitive agent is approved for practical treatment. Given excessive lipid deposition and cellular oxidative stress are two main inducers MAFLD, developing synergistic therapeutic agents that enhance metabolism antioxidative ability effective routes MAFLD therapy. Herein, a novel kind bio‐functional carbon dots (MTCDs) derived from metformin tea polyphenols based on fused pharmacophore strategy developed. The surface MTCDs retains abundant phenolic hydroxyl guanidine groups, which designed to reduce both in liver. Moreover, by finely controlling charge, exhibit excellent lysosome targeting functionality with favorable biocompatibility low biotoxicity. Mechanistical studies further reveal treatment protects lysosomes damage activates hepatocyte AMP‐activated protein kinase signaling, initiates lipophagy progress accelerate lipolysis consumption. Collectively, these propose an “two birds stone” tool therapy suggest viable multi‐pharmacophore development.

Язык: Английский

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ROS-Responsive Hydrogels: from Design, Additive Manufacturing to Biomedical Applications

Materials Horizons, Год журнала: 2024, Номер 11(16), С. 3721 - 3746

Опубликована: Янв. 1, 2024

Hydrogels with intricate 3D networks and high hydrophilicity have qualities resembling those of biological tissues, making them ideal candidates for use as smart biomedical materials. Reactive oxygen species (ROS) responsive hydrogels are an innovative class hydrogels, cross-linked by ROS-responsive modules through covalent interactions, coordination or supramolecular interactions. Due to the introduction ROS response modules, this exhibits a sensitive oxidative stress microenvironment existing in organisms. Simultaneously, due modularity structure, can be manufactured on large scale additive manufacturing. This review will delve into design, fabrication, applications hydrogels. The main goal is clarify chemical principles that govern mechanism these further providing new perspectives methods designing hydrogel

Язык: Английский

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Microenvironment-responsive nanomedicines: a promising direction for tissue regeneration

Military Medical Research, Год журнала: 2024, Номер 11(1)

Опубликована: Окт. 21, 2024

Abstract Severe tissue defects present formidable challenges to human health, persisting as major contributors mortality rates. The complex pathological microenvironment, particularly the disrupted immune landscape within these defects, poses substantial hurdles existing regeneration strategies. However, emergence of nanobiotechnology has opened a new direction in immunomodulatory nanomedicine, providing encouraging prospects for and restoration. This review aims gather recent advances nanomedicine foster regeneration. We begin by elucidating distinctive features local microenvironment defective tissues its crucial role Subsequently, we explore design functional properties nanosystems. Finally, address clinical translation development, aiming propose potent approach enhance through synergistic modulation integration.

Язык: Английский

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Sonochemical Synthesis of Natural Polyphenolic Nanoparticles for Modulating Oxidative Stress

Small, Год журнала: 2024, Номер 20(35)

Опубликована: Апрель 29, 2024

Natural polyphenolic compounds play a vital role in nature and are widely utilized as building blocks the fabrication of emerging functional nanomaterials. Although diverse methodologies developed recent years, challenges purification, uncontrollable reaction processes additional additives persist. Herein, modular facile methodology is reported toward natural nanoparticles. By utilizing low frequency ultrasound (40 kHz), assembly various successfully induced, allowing for precise control over particle formation process. The resulting nanoparticles possessed excellent vitro antioxidative abilities vivo therapeutic effects typical oxidative stress models including wound healing acute kidney injury. This study opens new avenues materials from naturally occurring blocks, offering promising prospects future advancements this field.

Язык: Английский

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