Precision Chemistry,
Год журнала:
2024,
Номер
2(11), С. 563 - 569
Опубликована: Авг. 24, 2024
Given
its
high
gravimetric
energy
density
and
status
as
a
clean
fuel
when
derived
from
renewables,
hydrogen
(H2)
is
considered
premier
candidate
for
storage;
however,
low
volumetric
limits
broader
application.
Chemical
storage
through
the
reversible
incorporation
of
H2
into
chemical
bonds
offers
promising
solution
to
density,
circumventing
subpar
densities
substantial
infrastructure
investments
associated
with
physical
methods.
Metal
hydrides
are
candidates
because
their
capacity
tunability
nanostructuring
alloying.
Moreover,
metal
hydride/H2
interconversion
may
be
interfaced
electrochemistry,
which
potential
solutions
some
challenges
traditional
thermochemical
platforms.
In
this
Perspective,
we
describe
anticipated
electrochemically
mediated
interconversion,
including
thermodynamic
efficiencies
hydride
formation,
sluggish
kinetics,
electrode
passivation.
Additionally,
propose
these
problems
design
molecular
mediators
that
control
factors
such
solubility,
particle
morphology,
affinity.
Realization
an
platform
introduces
new
tools
address
platforms
contributes
toward
development
room-temperature
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(10), С. 7275 - 7279
Опубликована: Май 3, 2024
An
unprecedented
DDQ-mediated
oxidative
aromatization
of
2-bezylidene-dihydrofurans
yielding
2-alkenyl-furans
is
disclosed.
Integration
this
transformation
with
a
prior
Pd-catalyzed
reaction
α-propargylic-β-ketoesters
and
(hetero)aryl
halides
into
one-pot
cascade
process
opens
direct
modular
route
to
highly
substituted
2-vinyl-furans.
Experimental
computational
studies
reveal
that
the
crucial
step
oxidative-aromatization
involves
facile
hydride
transfer
from
dihydrofuran
ring
O-center
DDQ.
Organic Letters,
Год журнала:
2024,
Номер
26(28), С. 5972 - 5977
Опубликована: Июль 5, 2024
Unprotected
alicyclic
amines
undergo
α-C-H
bond
phosphonylation
via
a
two-stage
one-pot
process
involving
the
oxidation
of
amine-derived
lithium
amides
with
simple
ketone
oxidants,
generating
transient
imines
which
are
then
captured
phosphites
or
phosphine
oxides.
Amines
an
existing
α-substituent
regioselective
α'-phosphonylation.
Amine
α-arylation
and
α'-phosphonylation
can
be
combined,
difunctionalized
product
in
single
operation.
Organic Letters,
Год журнала:
2024,
Номер
26(31), С. 6742 - 6747
Опубликована: Июль 26, 2024
Fluorinated
rings
have
emerged
as
privileged
structural
modules
in
the
fields
of
drug
discovery
and
materials
research.
The
incorporation
fluorine
atoms
into
aromatic
or
heterocycles
can
lead
to
significant
improvements
physicochemical
biological
properties
small
molecules,
making
them
valuable
components
design
new
drugs
functional
materials.
Herein,
we
presented
a
cobalt-catalyzed
C–H
oxidation/gem-difluorination
cascade
reaction
readily
available
cyclic
ethers
with
difluoroenoxysilanes,
affording
series
gem-difluorinated
analogues
moderate
high
yields.
obtained
products
versatile
fluoroalkyl
building
blocks
were
showcased
through
divergent-oriented
transformations.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(16), С. 11281 - 11292
Опубликована: Авг. 5, 2024
The
TEMPO
oxoammonium
cation
has
been
proven
to
be
both
an
efficient
oxidizing
reagent
and
electrophilic
substrate
frequently
found
in
organic
reactions.
Here,
we
report
that
this
versatile
chemical
can
also
used
as
promoter
for
C-
N-glycosylation
reactions
through
a
Ferrier
rearrangement
with
moderate
high
yields.
This
unprecedented
reactivity
is
explained
terms
of
Lewis
acid
activation
glycal
by
Precision Chemistry,
Год журнала:
2024,
Номер
2(11), С. 563 - 569
Опубликована: Авг. 24, 2024
Given
its
high
gravimetric
energy
density
and
status
as
a
clean
fuel
when
derived
from
renewables,
hydrogen
(H2)
is
considered
premier
candidate
for
storage;
however,
low
volumetric
limits
broader
application.
Chemical
storage
through
the
reversible
incorporation
of
H2
into
chemical
bonds
offers
promising
solution
to
density,
circumventing
subpar
densities
substantial
infrastructure
investments
associated
with
physical
methods.
Metal
hydrides
are
candidates
because
their
capacity
tunability
nanostructuring
alloying.
Moreover,
metal
hydride/H2
interconversion
may
be
interfaced
electrochemistry,
which
potential
solutions
some
challenges
traditional
thermochemical
platforms.
In
this
Perspective,
we
describe
anticipated
electrochemically
mediated
interconversion,
including
thermodynamic
efficiencies
hydride
formation,
sluggish
kinetics,
electrode
passivation.
Additionally,
propose
these
problems
design
molecular
mediators
that
control
factors
such
solubility,
particle
morphology,
affinity.
Realization
an
platform
introduces
new
tools
address
platforms
contributes
toward
development
room-temperature
