Nrf2 Regulates Oxidative Stress and Its Role in Cerebral Ischemic Stroke

Antioxidants, Год журнала: 2022, Номер 11(12), С. 2377 - 2377

Опубликована: Ноя. 30, 2022

Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain, which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there are limited effective clinical treatments for cerebral stroke, and recovery blood circulation will lead ischemia-reperfusion injury (CIRI). involves many pathological processes such as oxidative stress, inflammation, mitochondrial dysfunction. Nuclear factor erythroid 2-related 2 (Nrf2), one most critical antioxidant transcription factors cells, can coordinate various cytoprotective inhibit stress. Targeting Nrf2 considered potential strategy prevent treat injury. During ischemia, participates signaling pathways Keap1, PI3K/AKT, MAPK, NF-κB, HO-1, then alleviates or CIRI inhibiting anti-inflammation, maintaining homeostasis, protecting blood–brain barrier, ferroptosis. In this review, we have discussed structure Nrf2, mechanisms related research on treatment through pathway recent years, expounded important role future stroke.

Язык: Английский

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The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114671 - 114671

Опубликована: Апрель 8, 2023

Stroke is one of the leading causes death and long-term disability worldwide. More than 80 % strokes are ischemic, caused by an occlusion cerebral arteries. Without question, restoration blood supply as soon possible first therapeutic strategy. Nonetheless paradoxically, reperfusion can further aggravate injury through a series reactions known ischemia-reperfusion (CIRI). Mitochondria play vital role in promoting nerve survival neurological function recovery mitochondrial dysfunction considered characteristics CIRI. Neurons often die due to oxidative stress imbalance energy metabolism following CIRI, there strong association with dysfunction. Altered dynamics reaction stress. Mitochondrial refers maintenance integrity, distribution, size mitochondria well their ability resist external stimuli continuous cycle fission fusion. Therefore, improving means treating This review discusses relationship between CIRI emphasizes potential approach improve prognosis

Язык: Английский

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Diosmetin alleviates S. aureus-induced mastitis by inhibiting SIRT1/GPX4 mediated ferroptosis

Life Sciences, Год журнала: 2023, Номер 331, С. 122060 - 122060

Опубликована: Авг. 29, 2023

Язык: Английский

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Novel insight into the therapeutical potential of flavonoids from traditional Chinese medicine against cerebral ischemia/reperfusion injury

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Фев. 29, 2024

Cerebral ischemia/reperfusion injury (CIRI) is a major contributor to poor prognosis of ischemic stroke. Flavonoids are broad family plant polyphenols which abundant in traditional Chinese medicine (TCM) and have beneficial effects on several diseases including Accumulating studies indicated that flavonoids derived from herbal TCM effective alleviating CIRI after stroke vitro or vivo , exhibit favourable therapeutical potential. Herein, we systematically review the classification, metabolic absorption, neuroprotective efficacy, mechanisms against CIRI. The literature suggest exert potential medicinal functions suppressing excitotoxicity, Ca 2+ overloading, oxidative stress, inflammation, thrombin’s cellular toxicity, different types programmed cell deaths, protecting blood-brain barrier, as well promoting neurogenesis recovery stage following Furthermore, identified certain matters should be taken into account future research, proposed difficulties opportunities transforming TCM-derived medications functional foods for treatment prevention Overall, this aim provide novel ideas identification new prospective medication candidates therapeutic strategy

Язык: Английский

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Cocoa flavanols, Nrf2 activation, and oxidative stress in peripheral artery disease: mechanistic findings in muscle based on outcomes from a randomized trial

AJP Cell Physiology, Год журнала: 2024, Номер 326(2), С. C589 - C605

Опубликована: Янв. 8, 2024

The current study supports the hypothesis that in people with PAD, cocoa flavanols activate Nrf2, thereby increasing antioxidant protein levels, protecting against skeletal muscle damage, and mitochondrial abundance. These results suggest Nrf2 activation may be an important therapeutic target for improving walking performance PAD.

Язык: Английский

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Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(3)

Опубликована: Март 1, 2024

Abstract Objectives FTO is known to be involved in cerebral ischemia/reperfusion (I/R) injury. However, its related specific mechanisms during this condition warrant further investigations. This study aimed at exploring the impacts of and FYN/DRP1 axis on mitochondrial fission, oxidative stress (OS), ferroptosis I/R injury underlying mechanisms. Methods The models were established mice via temporary middle artery occlusion/reperfusion (tMCAO/R) hypoxia/reoxygenation induced mouse hippocampal neurons oxygen–glucose deprivation/reoxygenation (OGD/R). After gain‐ loss‐of‐function assays, gene expression was detected, along with examination OS‐ ferroptosis‐related marker levels, neuronal degeneration infarction, cell viability apoptosis. binding FYN, m6A modification levels interaction between FYN Drp1 evaluated. Results downregulated upregulated tMCAO/R OGD/R models. overexpression inhibited OS, suppress mice, which reversed by overexpressing FYN. also suppressed fission increase survival inhibit apoptosis models, aggravated additionally inhibiting DRP1. inactive signaling, thus reducing enhancing cells. Conclusions through modification, thereby subduing activity relieving

Язык: Английский

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Modulating NLRP3 Inflammasomes in Idiopathic Pulmonary Fibrosis: A Comprehensive Review on Flavonoid-Based Interventions

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Abstract Idiopathic Pulmonary Fibrosis (IPF) is a severe, rapidly advancing disease that drastically diminishes life expectancy. Without treatment, it can progress to lung cancer. The precise etiology of IPF remains unknown, but inflammation and damage the alveolar epithelium are widely thought be pivotal in its development. Research has indicated activating NLRP3 inflammasome crucial mechanism pathogenesis, as triggers release pro-inflammatory cytokines such IL-1β, IL-18, TGF-β. These contribute myofibroblast differentiation extracellular matrix (ECM) accumulation. Currently, treatment options for limited. Only two FDA-approved medications, pirfenidone nintedanib, available. While these drugs decelerate progression, they come with range side effects do not cure disease. Additional strategies primarily involve supportive care therapy. Emerging research highlighted numerous flavonoids derived from traditional medicines inhibit critical regulators responsible inflammasome. show promise potential therapeutic agents managing IPF, offering new avenue targets core inflammatory processes this debilitating condition. Graphical

Язык: Английский

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Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway

Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 22

Опубликована: Сен. 30, 2022

Delayed neurocognitive recovery (dNCR) is a prevalent perioperative neurological complication in older patients and has common characteristics such as acute cognitive dysfunction, impaired memory, inattention. Mesenchymal stem cell-derived exosomes (MSCs-Exo) are enclosed by lipid bilayer contain proteins, DNA, miRNA, other components, which important mediators of intercellular communication. It been reported that could play an role the treatment neurodegenerative diseases, nerve injury, diseases. In this study, we examined effects MSCs-Exo on dNCR aged mice after exploratory laparotomy evaluated their potential regulatory mechanisms. We found ameliorated impairment mice. inhibit hippocampus ferroptosis increase expression silent information regulator 1 (SIRT1), factor nuclear factor-erythroid 2-related 2 (Nrf2), heme oxygenase-1 (HO-1) Interestingly, above were abolished SIRT1 selective inhibitor EX-527. conclusion, these findings indicated can ameliorate inhibiting via activating SIRT1/Nrf2/HO-1 signaling pathway, providing avenue for dNCR.

Язык: Английский

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Review of the Role of Ferroptosis in Testicular Function

Nutrients, Год журнала: 2022, Номер 14(24), С. 5268 - 5268

Опубликована: Дек. 10, 2022

Iron is an important metal element involved in the regulation of male reproductive functions and has dual effects on testicular tissue. A moderate iron content necessary to maintain testosterone synthesis spermatogenesis. overload can lead dysfunction by triggering oxidative stress, lipid peroxidation, even ferroptosis. Ferroptosis iron-dependent form cell death that characterized overload, mitochondrial damage, glutathione peroxidase depletion. This review summarizes regulatory mechanism ferroptosis research progress caused endogenous exogenous toxicants. The purpose present provide a theoretical basis for relationship between function. Some toxic substances or danger signals cause inducing It crucial deeply explore mechanism, which will help further elucidate molecular dysfunction. worth noting does not exist alone but rather coexists with other forms (such as apoptosis, necrosis, autophagic death). Alleviating may completely reverse various risk factors.

Язык: Английский

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Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia/reperfusion injury

Journal of Neuroinflammation, Год журнала: 2022, Номер 19(1)

Опубликована: Окт. 26, 2022

Abstract Background The aim of this study was to establish a complete retinal cell atlas ischemia–reperfusion injury by single-cell RNA sequencing, and explore the underlying mechanism in mice. Methods Single-cell sequencing used evaluate changes mouse ischemia reperfusion model. In vivo vitro experiments were performed verify protective effect inhibiting ferroptosis injury. Results After injury, cells significantly reduced, accompanied activation myeloid large amount blood-derived immune infiltration. IFNG, MAPK NFKB signaling pathways neuronal cells, together with TNF pathway give rise strong inflammatory response I/R state. Besides, expression genes implicating iron metabolism, oxidative stress multiple programed death have changed subtypes described above. Especially ferroptosis-related blocking process could apparently alleviate responses enhance ganglion survival. Conclusions We established comprehensive landscape at level, revealing important role during targeted inhibition can effectively protect structure function.

Язык: Английский

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