Flavonoids for gastrointestinal tract local and associated systemic effects: A review of clinical trials and future perspectives

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Flavonoids are naturally occurring dietary phytochemicals with significant antioxidant effects aside from several health benefits. People often consume them in combination other food components. Compiling data establishes a link between bioactive flavonoids and prevention of diseases animal models, including cardiovascular diseases, diabetes, gut dysbiosis, metabolic dysfunction-associated steatotic liver disease (MASLD). However, numerous clinical studies have demonstrated the ineffectiveness contradicting rodent thereby challenging validity using as supplements. This review provides perspective to emphasize effective roles well summarize their specific mechanisms animals briefly. First, this offers an in-depth elucidation processes within human, encompassing small, large intestine, liver. Furthermore, comprehensive overview various functions gastrointestinal tract, hindering breakdown assimilation macronutrients, such polysaccharides lipids, regulating hormone secretion inhibition mineral iron absorption. In unabsorbed major portion interact flora leading biotransformation. Once absorbed circulated bloodstream, or metabolites exert beneficial systemic effects. Lastly, we examine protective disorders, endothelial dysfunction, MASLD, disease, obesity, hyperlipidemia, insulin resistance. conclusion, outlines safety future prospects field health, especially syndrome (MetS).

Язык: Английский

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Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1098 - 1098

Опубликована: Янв. 27, 2025

This article reviews the synergistic effects of antioxidant-enriched functional foods and exercise in improving metabolic health, focusing on underlying molecular mechanisms. The review incorporates evidence from PubMed, SCOPUS, Web Science, PsycINFO, reference lists relevant up to 20 December 2024, highlighting central role Nrf2 pathway. As a critical regulator oxidative stress adaptation, mediates benefits these interventions. presents an innovative approach understanding regulation inflammation, its potential prevention treatment various diseases, including cancer, neurodegenerative disorders, cardiovascular pulmonary diabetes, inflammatory conditions, ageing, infections such as COVID-19. novelty this study is investigate bioactive compounds found (such polyphenols, flavonoids, vitamins) exercise-induced activation combined reveals their improve insulin sensitivity lipid metabolism reduce offering promising strategy for management chronic diseases. However, there are significant gaps current research, particularly regarding mechanisms interaction between diet, physical activity, activation, well long-term different populations, those with In addition, interactions other signalling pathways, AMPK, NF-κB, PI3K/Akt, collective contributions health explored. Furthermore, novel biomarkers presented assess impact strategies, NAD+/NADH ratio, GSH markers mitochondrial health. findings provide valuable insights into how integration antioxidant-rich diet regular can by activating related pathways represent strategies disorders. Further studies needed fully understand therapeutic interventions diseases stress, disease, cancer.

Язык: Английский

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Biomaterial-based vascularization strategies for enhanced treatment of peripheral arterial disease

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 12, 2025

Язык: Английский

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Microvegetables and Their Potential Health Relevance: A Systematic Review of In Vitro and In Vivo Evidence

Journal of Food Biochemistry, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

A rise in noncommunicable disease (NCD) prevalence has been partly attributed to the low intake of food groups rich phytochemicals, particularly fruits and vegetables. For this reason, microvegetables (MV) are an emerging functional group. Nutrient‐dense with bioactive compounds, MV exhibit properties that may be relevant for NCD malnutrition risk modulation. No chronic supplementation human clinical trials have conducted. However, experimental vitro vivo studies shown can exert a range beneficial effects. In systematic review, we analysed effects such investigations discussed potential mechanisms involved. bibliographical search was performed PubMed Scopus, based on inclusion criteria, 28 articles were summarised critically discussed. Twelve demonstrated direct antioxidant capabilities MVs via assays. Few investigated more physiologically impact endogenous cellular systems. proapoptotic activity immortalised cell lines, limited evidence indicating anti‐inflammatory, lipid gut microbiota‐modifying These warrant further investigation evaluate their translational potential, our summary literature offers rationale basis trials.

Язык: Английский

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Redox signaling in age-related vascular disease and wound healing

Elsevier eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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Flavonoids and Other Polyphenols: Bioactive Molecules from Traditional Medicine Recipes/Medicinal Plants and Their Potential for Phytopharmaceutical and Medical Application

Molecules, Год журнала: 2024, Номер 29(23), С. 5760 - 5760

Опубликована: Дек. 5, 2024

Currently, natural bioactive ingredients and/or raw materials are of significant interest to scientists around the world. Flavonoids and other polyphenols a major group phytochemicals that have been researched noted as molecules. They offer several pharmacological medical benefits. This current review aims (1) illustrate their benefits for human health, such antioxidant, anti-aging, anti-cancer, anti-inflammatory, anti-microbial, cardioprotective, neuroprotective, UV-protective effects, also (2) perform quality evaluation traditional medicines future application. Consequently, keywords were searched on Scopus, Google Scholar, PubMed so search related publications. Then, those publications carefully checked in order find non-redundant studies matched objective this review. According review, researchers worldwide very interested discovering potential flavonoids polyphenols, used taken from medicinal plants, relation pharmaceutical applications. Many focus health tested using silico, vitro, vivo models. However, few carried out clinical trials trustworthy subject sizes accordance with practice guidelines. Additionally, interesting research directions perspectives highlighted work.

Язык: Английский

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Dietary Polyphenols as Anti-Aging Agents: Targeting the Hallmarks of Aging

Nutrients, Год журнала: 2024, Номер 16(19), С. 3305 - 3305

Опубликована: Сен. 29, 2024

Background: Aging is a natural biological process influenced by multiple factors and significant contributor to various chronic diseases. Slowing down the aging extending health span have been pursuits of scientific field. Methods: Examination effects dietary polyphenols on hallmarks such as genomic instability, telomere attrition, epigenetic alterations, loss proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, inflammation, dysbiosis. Results: Polyphenols, abundant in nature, exhibit numerous activities, including antioxidant effects, free radical scavenging, neuroprotection, anti-aging properties. These compounds are generally safe effective potentially slowing preventing age-related disorders. Conclusions: The review encourages development novel therapeutic strategies using create holistic therapies nutritional supplements.

Язык: Английский

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Evaluation of the Bioactive Compounds of Apis mellifera Honey Obtained from the Açai (Euterpe oleracea) Floral Nectar

Molecules, Год журнала: 2024, Номер 29(19), С. 4567 - 4567

Опубликована: Сен. 25, 2024

The biodiversity of Brazil provides an excellent climate and favorable pollination conditions for Apis mellifera L., especially in the Eastern Amazon region, which boasts vast floral wealth, including abundance açaí (Euterpe oleracea) flowers fruits. In present study, seven types honey were evaluated: three containing nectar from (Açaí honey) collected region Breu Branco (AH1 AH2) Açaí Santa Maria (AH3), both state Pará, Brazil) four honeys different regions (Aroeira Minas Gerais, Cipó-Uva Distrito Federal, Mangue Timbó Rio Grande do Sul). characteristics these evaluated by examining their physicochemical properties, melissopalynological aspects, color, antioxidant potential, constituent compounds, confirmed through GC-MS analysis. presented results similar to those other honeys, aligning with Brazilian legislation norms, but differed high values free acidity, apparent sugars, lower reducing are directly related botanical origin. These differences correlate unique flavor distinct aroma characteristics. Melissopalynological analysis origin nectar, had a color range amber dark amber. demonstrated capacity superior flavonoid polyphenol content compared particularly (AH1), times combat radicals highest potential honey). presence properties as well anti-inflammatory, antibacterial, antimicrobial, antitumor capabilities have not yet been fully studied.

Язык: Английский

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Revitalizing Muscle Regeneration: Cocoa Polyphenols Shield Mitochondrial Integrity and Boost Myogenesis Under Oxidative Stress

Microscopy Research and Technique, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 30, 2024

ABSTRACT In this study, we describe the effect of cocoa polyphenol extract (CPE, from flavanols‐rich cocoa) on myogenic differentiation in murine myoblasts (C2C12 cells) exposed to H 2 O . The program was monitored using morphological, ultrastructural, and molecular approaches. Treatment with 100 μM for 1 h decreased cell viability. C2C12 (D1) shows more apoptotic necrotic cells, mitochondria appear emptied, cristae heavily damaged. To evaluate CPE myoblast viability myotube formation, 10 μg/mL were added 24 prior treatment cells supplemented fresh every during differentiation. Supplementation protected ‐induced oxidative damage both at early late (D6) phases differentiation, preventing death mitochondrial damage. number (per area surface) increased 2‐fold control CPE‐supplemented myotubes D6 showed a greater extension than D1. At D1 monolayers surface inner features relatively comparable untreated suggesting that supplementation significantly mitigated Preliminary data obtained by index (Giemsa staining) suggested partially myogenesis inhibition. seems preserve integrity ability oxidatively injured ensuing further nutraceutical perspectives.

Язык: Английский

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Epicatechin Derivatives in Tissue Engineering: Antioxidant, Anti-Inflammatory, Regenerative Use

Tissue Engineering Part B Reviews, Год журнала: 2024, Номер unknown

Опубликована: Дек. 10, 2024

Epicatechin (EC)-based derivatives have garnered significant attention for their powerful antioxidant, anti-inflammatory, anticancer, and antibacterial properties, all of which are attributed to the phenolic hydroxyl groups in structure. These compounds promising regenerative medicine, particularly as bioactive components scaffolds. This review provides an in-depth analysis mechanisms by EC-based materials enhance tissue repair, examining application various scaffold forms, such hydrogels, nanoparticles, nanofibers. study also addresses challenges stability bioavailability associated with ECs proposes encapsulation techniques overcome these barriers. The potential clinical benefits medicine role fostering advancements engineering discussed, making this a valuable resource guiding future studies on integration into practice.

Язык: Английский

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