Photochemical & Photobiological Sciences, Год журнала: 2022, Номер 21(5), С. 849 - 861
Опубликована: Фев. 3, 2022
Язык: Английский
Applied Sciences, Год журнала: 2022, Номер 12(21), С. 10909 - 10909
Опубликована: Окт. 27, 2022
Chirality plays an important role in the development of many pharmaceuticals, being a general property ‘handedness’; nevertheless, large number pharmaceuticals are still marketed and administered as racemates. is all around even within us; indeed, receptors enzymes chiral entities interact specific manner with drugs. Consequently, controlling enantiomeric purity isolating enantiomers from drugs remains crucial subject for analytical, clinical, regulatory purposes, thus, improving drug safety profile. The classical examples spontaneous enantiomerization severe toxicity related to chirality represented by ibuprofen thalidomide, respectively, but numerous other cases have been reported literature. This review intends offer brief overview on most common used therapy treatment various diseases.
Язык: Английский
Процитировано
71
Chemical Reviews, Год журнала: 2023, Номер 123(15), С. 9397 - 9446
Опубликована: Июль 7, 2023
The proportion of approved chiral drugs and drug candidates under medical studies has surged dramatically over the past two decades. As a consequence, efficient synthesis enantiopure pharmaceuticals or their synthetic intermediates poses profound challenge to medicinal process chemists. significant advancement in asymmetric catalysis provided an effective reliable solution this challenge. successful application transition metal catalysis, organocatalysis, biocatalysis pharmaceutical industries promoted discovery by precise preparation enantio-enriched therapeutic agents, facilitated industrial production active ingredient economic environmentally friendly fashion. present review summarizes most recent applications (2008–2022) industry ranging from scales pilot levels. It also showcases latest achievements trends agents with state art technologies catalysis.
Язык: Английский
Процитировано
43
Chemical Reviews, Год журнала: 2024, Номер 124(9), С. 5930 - 6050
Опубликована: Апрель 30, 2024
Since the last century, we have witnessed development of molecular magnetism which deals with magnetic materials based on species, i.e., organic radicals and metal complexes. Among them, broadest attention was devoted to molecule-based ferro-/ferrimagnets, spin transition materials, including those exploring electron transfer, nanomagnets, such as single-molecule magnets (SMMs), qubits, stimuli-responsive materials. Their physical properties open application horizons in sensors, data storage, spintronics, quantum computation. It found that various optical phenomena, thermochromism, photoswitching characteristics, luminescence, nonlinear chiroptical effects, well responsivity external stimuli, can be implemented into Moreover, fruitful interactions these effects provide new cross-effects multifunctionality, enriching applications optical, electronic, devices. This Review aims show scope phenomena generated recent advances areas high-temperature photomagnetism, thermometry utilizing SMMs, addressability magneto-chiral dichroism, opto-magneto-electric multifunctionality. These findings are discussed context types accessible for classes
Язык: Английский
Процитировано
32
Russian Chemical Reviews, Год журнала: 2023, Номер 92(12), С. RCR5104 - RCR5104
Опубликована: Дек. 1, 2023
After the appearance of green chemistry concept, which was introduced in vocabulary early 1990s, its main statements have been continuously developed and modified. Currently, there are 10–12 cornerstones that should form basis for an ideal chemical process. This review analyzes accumulated experience achievements towards design products processes reduce or eliminate use generation hazardous substances. The presents views leading Russian scientists specializing various fields this subject, including homogeneous heterogeneous catalysis, fine basic organic synthesis, electrochemistry, polymer chemistry, based on bio-renewable feedstocks energetic compounds materials. A new approach to quantitative evaluation environmental friendliness by authors is described. <br> bibliography includes 1761.
Язык: Английский
Процитировано
39
Chirality, Год журнала: 2024, Номер 36(7)
Опубликована: Июль 1, 2024
ABSTRACT Chirality, the property of molecules having mirror‐image forms, plays a crucial role in pharmaceutical and biomedical research. This review highlights its growing importance, emphasizing how chiral drugs nanomaterials impact drug effectiveness, safety, diagnostics. Chiral serve as precise diagnostic tools, aiding accurate disease detection through unique biomolecule interactions. The article extensively covers applications treating cardiovascular diseases, CNS disorders, local anesthesia, anti‐inflammatories, antimicrobials, anticancer drugs. Additionally, it explores emerging field nanomaterials, highlighting their suitability for diagnostics therapeutics, enhancing medical treatments.
Язык: Английский
Процитировано
10
Nature Reviews Chemistry, Год журнала: 2024, Номер 8(11), С. 851 - 869
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
9
ACS Catalysis, Год журнала: 2024, Номер 14(4), С. 2202 - 2206
Опубликована: Янв. 26, 2024
Continuous-flow hydrogenations provide greatly improved reaction efficiency due to the efficient mass-transfer between heterogeneous catalysts and hydrogen gas. However, reported flow were limited only simple functional group transformations, development of sophisticated catalysis such as enantioselective reductive C–C bond formations remains challenging. Herein, we have developed continuous-flow cyclization 1,6-enynes using chiral supported on heteropoly acid/amine-functionalized SiO2 composites in our group. Investigations under conditions revealed that tuning structure acids amines could improve catalyst performance. A variety substrates produce products with high yields enantioselectivities optimized without leaching Rh catalyst. Mechanistic studies cause deactivation this transformation.
Язык: Английский
Процитировано
8
iScience, Год журнала: 2022, Номер 25(3), С. 103892 - 103892
Опубликована: Фев. 10, 2022
Multi-step organic syntheses of various drugs, active pharmaceutical ingredients, and other pharmaceutically agriculturally important compounds have already been reported using flow synthesis. Compared to batch, hazardous reactive reagents can be handled safely in flow. This review discusses the pros cons chemistry today's scenario recent developments devices. The majorly emphasizes on synthesis products last five years including flibanserin, imatinib, buclizine, cinnarizine, cyclizine, meclizine, ribociclib, celecoxib, SC-560 mavacoxib, efavirenz, fluconazole, melitracen HCl, rasagiline, tamsulosin, valsartan, hydroxychloroquine. Critical steps new development selected are also discussed.
Язык: Английский
Процитировано
30
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(38)
Опубликована: Авг. 4, 2023
An automated high throughput multidimensional reaction screening platform based on an inline Fourier-transform infrared spectroscopy is presented. By combining flow chemistry, machine automation and analysis, the able to screen reactions in multidimensions (residence time, monomer concentration, degree of polymerization, temperature conversion) rapidly efficiently way. Kinetic data libraries associated with precision (absolute error <4 %), reproducibility density are built ease from platform. To test method, we screened reversible addition-fragmentation chain transfer polymerization methyl acrylate unmatched detail, ring opening metathesis methyl-5-norbornene-2-carboxylate. The method introduce a key step providing "big data" for driven research future, already at present allows precise prediction outcomes within high-dimensional chemical parameter space that screened.
Язык: Английский
Процитировано
22
Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(4), С. 1024 - 1030
Опубликована: Янв. 13, 2024
Abstract An asymmetric enantioselective flow process is reported for the formal synthesis of a 1,2,3,4‐tetrahydroquinoline selective estrogen receptor modulator. Starting from an easily available 2‐nitrochalcone, first part comprised telescoped nitro reduction/intramolecular cyclocondensation sequence using diboronic acid as simple reductant. Subsequent transfer hydrogenation in presence immobilized phosphoric organocatalyst followed by N ‐alkylation furnished targeted chiral intermediate. The approach ensures flexibility regarding scale synthesis, whilst minimizing need intermediate purifications and ensuring environmentally benign metal‐free conditions.
Язык: Английский
Процитировано
7