ChemBioChem,
Journal Year:
2022,
Volume and Issue:
23(22)
Published: Sept. 29, 2022
Herein,
we
show
how
the
merge
of
biocatalysis
with
flow
chemistry
aided
by
3D-printing
technologies
can
facilitate
organic
synthesis.
This
concept
was
exemplified
for
reductive
amination
benzaldehyde
catalysed
co-immobilised
amine
dehydrogenase
and
formate
in
a
continuous
micro-reactor.
For
this
purpose,
investigated
enzyme
co-immobilisation
covalent
binding,
or
ion-affinity
entrapment.
Entrapment
an
agarose
hydrogel
turned
out
to
be
most
promising
solution
biocatalytic
reaction.
Therefore,
developed
scalable
customisable
approach
whereby
containing
co-entrapped
dehydrogenases
cast
3D-printed
mould.
The
reactor
applied
over
120
h
afforded
47
%
analytical
yield
space-time
7.4
g
L
day
Applied Sciences,
Journal Year:
2022,
Volume and Issue:
12(21), P. 10909 - 10909
Published: Oct. 27, 2022
Chirality
plays
an
important
role
in
the
development
of
many
pharmaceuticals,
being
a
general
property
‘handedness’;
nevertheless,
large
number
pharmaceuticals
are
still
marketed
and
administered
as
racemates.
is
all
around
even
within
us;
indeed,
receptors
enzymes
chiral
entities
interact
specific
manner
with
drugs.
Consequently,
controlling
enantiomeric
purity
isolating
enantiomers
from
drugs
remains
crucial
subject
for
analytical,
clinical,
regulatory
purposes,
thus,
improving
drug
safety
profile.
The
classical
examples
spontaneous
enantiomerization
severe
toxicity
related
to
chirality
represented
by
ibuprofen
thalidomide,
respectively,
but
numerous
other
cases
have
been
reported
literature.
This
review
intends
offer
brief
overview
on
most
common
used
therapy
treatment
various
diseases.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(15), P. 9397 - 9446
Published: July 7, 2023
The
proportion
of
approved
chiral
drugs
and
drug
candidates
under
medical
studies
has
surged
dramatically
over
the
past
two
decades.
As
a
consequence,
efficient
synthesis
enantiopure
pharmaceuticals
or
their
synthetic
intermediates
poses
profound
challenge
to
medicinal
process
chemists.
significant
advancement
in
asymmetric
catalysis
provided
an
effective
reliable
solution
this
challenge.
successful
application
transition
metal
catalysis,
organocatalysis,
biocatalysis
pharmaceutical
industries
promoted
discovery
by
precise
preparation
enantio-enriched
therapeutic
agents,
facilitated
industrial
production
active
ingredient
economic
environmentally
friendly
fashion.
present
review
summarizes
most
recent
applications
(2008–2022)
industry
ranging
from
scales
pilot
levels.
It
also
showcases
latest
achievements
trends
agents
with
state
art
technologies
catalysis.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(9), P. 5930 - 6050
Published: April 30, 2024
Since
the
last
century,
we
have
witnessed
development
of
molecular
magnetism
which
deals
with
magnetic
materials
based
on
species,
i.e.,
organic
radicals
and
metal
complexes.
Among
them,
broadest
attention
was
devoted
to
molecule-based
ferro-/ferrimagnets,
spin
transition
materials,
including
those
exploring
electron
transfer,
nanomagnets,
such
as
single-molecule
magnets
(SMMs),
qubits,
stimuli-responsive
materials.
Their
physical
properties
open
application
horizons
in
sensors,
data
storage,
spintronics,
quantum
computation.
It
found
that
various
optical
phenomena,
thermochromism,
photoswitching
characteristics,
luminescence,
nonlinear
chiroptical
effects,
well
responsivity
external
stimuli,
can
be
implemented
into
Moreover,
fruitful
interactions
these
effects
provide
new
cross-effects
multifunctionality,
enriching
applications
optical,
electronic,
devices.
This
Review
aims
show
scope
phenomena
generated
recent
advances
areas
high-temperature
photomagnetism,
thermometry
utilizing
SMMs,
addressability
magneto-chiral
dichroism,
opto-magneto-electric
multifunctionality.
These
findings
are
discussed
context
types
accessible
for
classes
Russian Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
92(12), P. RCR5104 - RCR5104
Published: Dec. 1, 2023
After
the
appearance
of
green
chemistry
concept,
which
was
introduced
in
vocabulary
early
1990s,
its
main
statements
have
been
continuously
developed
and
modified.
Currently,
there
are
10–12
cornerstones
that
should
form
basis
for
an
ideal
chemical
process.
This
review
analyzes
accumulated
experience
achievements
towards
design
products
processes
reduce
or
eliminate
use
generation
hazardous
substances.
The
presents
views
leading
Russian
scientists
specializing
various
fields
this
subject,
including
homogeneous
heterogeneous
catalysis,
fine
basic
organic
synthesis,
electrochemistry,
polymer
chemistry,
based
on
bio-renewable
feedstocks
energetic
compounds
materials.
A
new
approach
to
quantitative
evaluation
environmental
friendliness
by
authors
is
described.
<br>
bibliography
includes
1761.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(38)
Published: Aug. 4, 2023
An
automated
high
throughput
multidimensional
reaction
screening
platform
based
on
an
inline
Fourier-transform
infrared
spectroscopy
is
presented.
By
combining
flow
chemistry,
machine
automation
and
analysis,
the
able
to
screen
reactions
in
multidimensions
(residence
time,
monomer
concentration,
degree
of
polymerization,
temperature
conversion)
rapidly
efficiently
way.
Kinetic
data
libraries
associated
with
precision
(absolute
error
<4
%),
reproducibility
density
are
built
ease
from
platform.
To
test
method,
we
screened
reversible
addition-fragmentation
chain
transfer
polymerization
methyl
acrylate
unmatched
detail,
ring
opening
metathesis
methyl-5-norbornene-2-carboxylate.
The
method
introduce
a
key
step
providing
"big
data"
for
driven
research
future,
already
at
present
allows
precise
prediction
outcomes
within
high-dimensional
chemical
parameter
space
that
screened.
Chirality,
Journal Year:
2024,
Volume and Issue:
36(7)
Published: July 1, 2024
ABSTRACT
Chirality,
the
property
of
molecules
having
mirror‐image
forms,
plays
a
crucial
role
in
pharmaceutical
and
biomedical
research.
This
review
highlights
its
growing
importance,
emphasizing
how
chiral
drugs
nanomaterials
impact
drug
effectiveness,
safety,
diagnostics.
Chiral
serve
as
precise
diagnostic
tools,
aiding
accurate
disease
detection
through
unique
biomolecule
interactions.
The
article
extensively
covers
applications
treating
cardiovascular
diseases,
CNS
disorders,
local
anesthesia,
anti‐inflammatories,
antimicrobials,
anticancer
drugs.
Additionally,
it
explores
emerging
field
nanomaterials,
highlighting
their
suitability
for
diagnostics
therapeutics,
enhancing
medical
treatments.
iScience,
Journal Year:
2022,
Volume and Issue:
25(3), P. 103892 - 103892
Published: Feb. 10, 2022
Multi-step
organic
syntheses
of
various
drugs,
active
pharmaceutical
ingredients,
and
other
pharmaceutically
agriculturally
important
compounds
have
already
been
reported
using
flow
synthesis.
Compared
to
batch,
hazardous
reactive
reagents
can
be
handled
safely
in
flow.
This
review
discusses
the
pros
cons
chemistry
today's
scenario
recent
developments
devices.
The
majorly
emphasizes
on
synthesis
products
last
five
years
including
flibanserin,
imatinib,
buclizine,
cinnarizine,
cyclizine,
meclizine,
ribociclib,
celecoxib,
SC-560
mavacoxib,
efavirenz,
fluconazole,
melitracen
HCl,
rasagiline,
tamsulosin,
valsartan,
hydroxychloroquine.
Critical
steps
new
development
selected
are
also
discussed.
ACS Catalysis,
Journal Year:
2024,
Volume and Issue:
14(4), P. 2202 - 2206
Published: Jan. 26, 2024
Continuous-flow
hydrogenations
provide
greatly
improved
reaction
efficiency
due
to
the
efficient
mass-transfer
between
heterogeneous
catalysts
and
hydrogen
gas.
However,
reported
flow
were
limited
only
simple
functional
group
transformations,
development
of
sophisticated
catalysis
such
as
enantioselective
reductive
C–C
bond
formations
remains
challenging.
Herein,
we
have
developed
continuous-flow
cyclization
1,6-enynes
using
chiral
supported
on
heteropoly
acid/amine-functionalized
SiO2
composites
in
our
group.
Investigations
under
conditions
revealed
that
tuning
structure
acids
amines
could
improve
catalyst
performance.
A
variety
substrates
produce
products
with
high
yields
enantioselectivities
optimized
without
leaching
Rh
catalyst.
Mechanistic
studies
cause
deactivation
this
transformation.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(4), P. 1024 - 1030
Published: Jan. 13, 2024
Abstract
An
asymmetric
enantioselective
flow
process
is
reported
for
the
formal
synthesis
of
a
1,2,3,4‐tetrahydroquinoline
selective
estrogen
receptor
modulator.
Starting
from
an
easily
available
2‐nitrochalcone,
first
part
comprised
telescoped
nitro
reduction/intramolecular
cyclocondensation
sequence
using
diboronic
acid
as
simple
reductant.
Subsequent
transfer
hydrogenation
in
presence
immobilized
phosphoric
organocatalyst
followed
by
N
‐alkylation
furnished
targeted
chiral
intermediate.
The
approach
ensures
flexibility
regarding
scale
synthesis,
whilst
minimizing
need
intermediate
purifications
and
ensuring
environmentally
benign
metal‐free
conditions.
