Organic Letters,
Год журнала:
2023,
Номер
25(30), С. 5692 - 5696
Опубликована: Июль 26, 2023
A
photocatalyzed,
efficient,
and
mild
approach
for
the
synthesis
of
various
substituted
isothiocyanates
from
amine
carbon
disulfide
was
reported
in
this
work.
This
expands
scope
photocatalytic
applications
provides
a
new
method
preparation
aliphatic
aromatic
isothiocyanates,
which
are
significant
organic
building
blocks
biological
diagnostic
markers.
Organic Letters,
Год журнала:
2023,
Номер
25(39), С. 7115 - 7119
Опубликована: Сен. 22, 2023
Despite
a
well-developed
and
growing
body
of
work
on
the
directed
evolution
hemoproteins,
potential
hemoproteins
to
catalyze
non-natural
reactions
remains
underexplored.
This
paper
reports
new
biocatalytic
strategy
for
one-pot
synthesis
unnatural
α-amino
acids.
Engineered
variants
dual-function
Vitreoscilla
hemoglobin
were
found
efficiently
N-H
insertion
C-H
sp3
alkylation,
providing
moderate
excellent
yields
(57%-95%)
acid
derivatives
turnover
numbers
(1425-2375).
Organic Letters,
Год журнала:
2023,
Номер
25(13), С. 2258 - 2263
Опубликована: Март 26, 2023
An
operationally
simple
and
efficient
domino
etiquette
has
been
developed
for
the
facile
construction
of
1,2-dithioles
employing
easily
accessible
dithioesters
as
a
three-atom
CCS
synthon
aryl
isothiocyanates
two-atom
CS
unit
in
absence
any
catalyst
additive
at
room
temperature
under
open
air.
The
reaction
proceeded
efficiently
affording
desired
good
yields
having
various
functional
groups
diverse
electronic
steric
nature.
This
approach
avoids
possible
toxicity
tiresome
workup
conditions
features
easy
to
handle,
cheap,
readily
reagents,
O2
green
oxidant,
gram-scale
ability.
Notably,
final
S-S
bond
formation
cascade
ring
follow
radical
pathway,
which
recognized
via
trapping
experiment
with
BHT
during
course
reaction.
exocyclic
C═N
position
3
1,2-dithiole
possesses
Z
stereochemistry.
Abstract
In
this
study,
supercritical
carbon
dioxide
(ScCO
2
),
which
is
a
sustainable
and
green
solvent,
was
used
as
reaction
medium
in
the
lipase‐catalyzed
synthesis
of
anthrone‐functionalized
benzylic
amines
for
first
time.
We
synthesized
target
compounds
via
multicomponent
cascade
aldehydes,
sulfonamides,
anthrones
ScCO
.
The
can
be
accomplished
good‐to‐excellent
yields
(77
%–95
%)
exhibit
good
functional
group
tolerance.
brief,
characterized
by
step
economy,
metal‐free
conditions,
environmentally
friendly
solvents,
biocatalysts.
Green Chemistry Letters and Reviews,
Год журнала:
2022,
Номер
15(3), С. 689 - 694
Опубликована: Июль 3, 2022
In
this
work,
an
efficient
synthesis
of
3-hydroxy
chromones
was
accomplished
through
oxidative
cyclization
mediated
by
lipase.
This
enzymatic
process
has
salient
features
environmental
friendliness,
mild
reaction
condition,
satisfactory
yield,
green
reusable
biocatalyst,
and
short
time.
The
proposed
method
expands
the
application
lipase
in
organic
synthesis.
Abstract
A
novel
oxadiazolone‐based
method
for
the
synthesis
of
3‐aminobenzisoxazoles
by
N−O
bond
formation
and
2‐aminobenzoxazoles
through
a
Tiemann‐type
rearrangement
has
been
developed.
The
these
two
pharmaceutically
relevant
heterocycles
was
realized
an
unexplored
retrosynthetic
disconnection
using
cyclic
nitrenoid
precursor‐based
strategy.
selective
isomers
significantly
influenced
steric
electronic
effects
substituents.
However,
tetrabutylammonium
chloride
(TBACl)
efficiently
promoted
over
formation.
Control
experiments
indicate
that
deprotonation
phenol
induces
both
rearrangements.
