Molecular Biology Reports,
Год журнала:
2024,
Номер
51(1)
Опубликована: Май 25, 2024
Abstract
Selenium
nanoparticles
(SeNPs)
are
an
appealing
carrier
for
the
targeted
delivery.
The
selenium
gaining
global
attention
because
of
potential
therapeutic
applications
in
several
diseases
e.g.,
rheumatoid
arthritis
(RA),
inflammatory
bowel
disease
(IBD),
asthma,
liver,
and
various
autoimmune
disorders
like
psoriasis,
cancer,
diabetes,
a
variety
infectious
diseases.
Despite
fact
still
there
is
no
recent
literature
that
summarises
SeNPs.
There
some
challenges
need
to
be
addressed
finding
targets
SeNPs
diseases,
functionalization
techniques
utilized
increase
SeNP’s
stability
while
facilitating
wide
drug-loaded
SeNP
distribution
tumor
areas
preventing
off-target
impacts
focus
on
understanding
more
about
aspects
better
science
behind
it.
Keeping
mind
we
have
focused
this
gap
try
summarize
all
key
therapies
cancer
treatment
numerous
strategies.
We
also
advancements
methodologies
mechanisms
biomedical
applications,
particularly
anticancer,
anti-inflammatory,
anti-infection
therapeutics.
Based
our
observation
found
could
potentially
useful
suppressing
viral
epidemics,
ongoing
COVID-19
pandemic,
complement
their
antibacterial
antiparasitic
uses.
significant
nanoplatforms
with
desirable
properties
clinical
translation.
Graphical
Molecules,
Год журнала:
2023,
Номер
28(13), С. 4932 - 4932
Опубликована: Июнь 22, 2023
The
role
of
nanotechnology
is
increasingly
important
in
our
society.
Through
it,
scientists
are
acquiring
the
ability
to
understand
structure
and
properties
materials
manipulate
them
at
scale
atoms
molecules.
Nanomaterials
forefront
rapidly
growing
field
nanotechnology.
synthesis
nanostructured
materials,
especially
metallic
nanoparticles,
has
attracted
tremendous
interest
over
past
decade
due
their
unique
properties,
making
these
excellent
indispensable
many
areas
human
activity.
These
special
can
be
attributed
small
size
large
specific
surface
area
which
very
different
from
those
bulk
materials.
Nanoparticles
sizes
shapes
needed
for
applications,
so
a
variety
protocols
required
produce
monodisperse
nanoparticles
with
controlled
morphology.
purpose
this
review
firstly
introduce
reader
basic
aspects
related
and,
secondly,
discuss
greater
detail.
This
article
explains
concepts
nanotechnology,
introduces
methods
synthesizing
describes
types,
possible
applications.
Of
proposed
metal
chemical
reduction
usually
preferred
because
it
easy
perform,
cost-effective,
efficient,
also
allows
control
structural
parameters
through
optimization
conditions.
Therefore,
method
discussed
more
detail—each
factor
by
described
detail,
i.e.,
precursors,
solvents,
reducing
agents,
stabilizers.
that
used
characterize
nanomaterials
described.
Finally,
based
on
available
literature
collection,
shown
how
changing
parameters/methods
affects
final
characteristics
nanoparticles.
Nanomaterials,
Год журнала:
2023,
Номер
13(3), С. 424 - 424
Опубликована: Янв. 19, 2023
Selenium
is
an
important
dietary
supplement
and
essential
trace
element
incorporated
into
selenoproteins
with
growth-modulating
properties
cytotoxic
mechanisms
of
action.
However,
different
compounds
selenium
usually
possess
a
narrow
nutritional
or
therapeutic
window
low
degree
absorption
delicate
safety
margins,
depending
on
the
dose
chemical
form
in
which
they
are
provided
to
organism.
Hence,
nanoparticles
(SeNPs)
emerging
as
novel
diagnostic
platform
decreased
toxicity
capacity
enhance
biological
Se-based
compounds.
Consistent
exciting
possibilities
offered
by
nanotechnology
diagnosis,
treatment,
prevention
diseases,
SeNPs
useful
tools
current
biomedical
research
exceptional
benefits
potential
therapeutics,
enhanced
bioavailability,
improved
targeting,
effectiveness
against
oxidative
stress
inflammation-mediated
disorders.
In
view
need
for
developing
eco-friendly,
inexpensive,
simple,
high-throughput
agents
that
can
also
ally
theranostic
purposes
exhibit
negligible
side
effects,
biogenic
receiving
special
attention.
The
present
manuscript
aims
be
reference
its
kind
providing
readership
thorough
comprehensive
review
emphasizes
current,
yet
expanding,
field
promise
hold
among
selenium-derived
products
to,
eventually,
elicit
future
developments.
First,
recalls
physiological
importance
oligo-element
introduces
unique
biological,
physicochemical,
optoelectronic,
catalytic
Se
nanomaterials.
Then,
it
addresses
significance
nanosizing
pharmacological
activity
(pharmacokinetics
pharmacodynamics)
cellular
interactions
SeNPs.
Importantly,
discusses
detail
role
biosynthesized
innovative
personalized
nanomedicine-based
therapies.
Finally,
this
explores
ongoing
context
SARS-CoV-2
pandemic
presents
key
prospects
translational
nanomedicine.
Materials,
Год журнала:
2023,
Номер
16(15), С. 5363 - 5363
Опубликована: Июль 30, 2023
The
resistance
of
microorganisms
to
antimicrobial
drugs
is
an
important
problem
worldwide.
To
solve
this
problem,
active
searches
for
components,
approaches
and
therapies
are
being
carried
out.
Selenium
nanoparticles
have
high
potential
activity.
relevance
their
application
indisputable,
which
can
be
noted
due
the
significant
increase
in
publications
on
topic
over
past
decade.
This
review
research
aims
provide
reader
with
up-to-date
information
properties
selenium
nanoparticles,
including
susceptible
microorganisms,
mechanisms
action
bacteria
effect
nanoparticle
describes
most
complete
antiviral,
antibacterial
antifungal
effects
nanoparticles.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Июнь 3, 2023
Herein,
four
endophytic
fungal
strains
living
in
healthy
roots
of
garlic
were
used
to
produce
selenium
nanoparticles
(Se-NPs)
via
green
synthesis.
Penicillium
verhagenii
was
found
be
the
most
efficient
Se-NPs
producer
with
a
ruby
red
color
that
showed
maximum
surface
plasmon
resonance
at
270
nm.
The
as-formed
crystalline,
spherical,
and
well-arranged
without
aggregation,
ranged
from
25
75
nm
size
zeta
potential
value
-32
mV,
indicating
high
stability.
Concentration-dependent
biomedical
activities
P.
verhagenii-based
observed,
including
promising
antimicrobial
activity
against
different
pathogens
(Escherichia
coli,
Pseudomonas
aeruginosa,
Bacillus
subtilis,
Staphylococcus
aureus,
Candida
albicans,
C.
glabrata,
tropicalis,
parapsilosis)
minimum
inhibitory
concentration
(MIC)
12.5-100
µg
mL-1.
biosynthesized
antioxidant
DPPH-scavenging
percentages
86.8
±
0.6%
1000
mL-1
decreased
19.3
4.5%
1.95
Interestingly,
also
anticancer
PC3
MCF7
cell
lines
IC50
225.7
3.6
283.8
7.5
mL-1,
respectively
while
it
is
remaining
biocompatible
normal
WI38
Vero
lines.
Additionally,
synthesized
effective
instar
larvae
medical
insect,
Aedes
albopictus
mortality
85.1
3.1,
67.2
1.2,
62.10
1.4,
51.0
1.0%
50
for
I,
II,
III,
IV-instar
larva,
respectively.
These
data
highlight
efficacy
cost-effective
eco-friendly
synthesis
applications.
Antibiotics,
Год журнала:
2023,
Номер
12(1), С. 115 - 115
Опубликована: Янв. 8, 2023
The
continuous
need
to
satisfy
world
food
demand
has
led
the
search
for
new
alternatives
combat
economic
losses
in
agriculture
caused
by
phytopathogenic
fungi.
These
organisms
cause
plant
diseases,
reducing
their
productivity
and
decreasing
fruit
quality.
Among
tools
being
explored
is
nanotechnology.
Nanoparticles
with
antimicrobial
properties
could
be
an
excellent
alternative
address
this
problem.
In
work,
selenium
nanoparticles
(SeNPs)
were
obtained
using
extracts
of
Amphipterygium
glaucum
leaves
(SeNPs-AGL)
Calendula
officinalis
flowers
(SeNPs-COF).
Characterization
SeNPs
was
performed
ability
as
antifungal
agents
against
two
commercially
relevant
pathogenic
fungi,
Fusarium
oxysporum
Colletotrichum
gloeosporioides,
evaluated.
Assays
different
concentrations
(0,
0.25,
0.5,
1.0,
1.7
mg/mL).
It
observed
that
both
had
activity
pathogens
at
0.25
mg/mL
above.
SeNPs-AGL
demonstrated
better
smaller
size
(around
8.0
nm)
than
SeNPs-COF
(134.0
nm).
FTIR
analysis
evidenced
existence
functional
groups
constitute
types
SeNPs.
There
are
factors
have
considered
such
nanoparticle
phytochemical
composition
used,
these
may
affect
bioavailability.
Molecules,
Год журнала:
2023,
Номер
28(24), С. 8125 - 8125
Опубликована: Дек. 15, 2023
Selenium
nanoparticles
(SeNPs)
are
extremely
popular
objects
in
nanotechnology.
"Green"
synthesis
has
special
advantages
due
to
the
growing
necessity
for
environmentally
friendly,
non-toxic,
and
low-cost
methods.
This
review
considers
biosynthesis
mechanism
of
bacteria,
fungi,
algae,
plants,
including
role
various
biological
substances
processes
reducing
selenium
compounds
SeNPs
their
further
packaging.
Modern
information
approaches
possible
biomedical
use
presented:
antimicrobial,
antiviral,
anticancer,
antioxidant,
anti-inflammatory,
other
properties,
as
well
mechanisms
these
processes,
that
have
important
potential
therapeutic
value.
Fungal Diversity,
Год журнала:
2024,
Номер
125(1), С. 1 - 71
Опубликована: Март 20, 2024
Abstract
The
field
of
mycology
has
grown
from
an
underappreciated
subset
botany,
to
a
valuable,
modern
scientific
discipline.
As
this
study
grown,
there
have
been
significant
contributions
science,
technology,
and
industry,
highlighting
the
value
fungi
in
era.
This
paper
looks
at
current
research,
along
with
existing
limitations,
suggests
future
areas
where
scientists
can
focus
their
efforts,
mycology.
We
show
how
become
important
emerging
diseases
medical
discuss
trends
potential
drug
novel
compound
discovery.
explore
phylogenomics,
its
potential,
outcomes
address
question
phylogenomics
be
applied
fungal
ecology.
In
addition,
functional
genomics
studies
are
discussed
importance
unravelling
intricate
mechanisms
underlying
behaviour,
interactions,
adaptations,
paving
way
for
comprehensive
understanding
biology.
look
research
building
materials,
they
used
as
carbon
sinks,
biocircular
economies.
numbers
always
great
interest
often
written
about
estimates
varied
greatly.
Thus,
we
needs
order
obtain
more
reliable
estimates.
aspects
machine
learning
(AI)
it
mycological
research.
Plant
pathogens
affecting
food
production
systems
on
global
scale,
such,
needed
area,
particularly
disease
detection.
latest
data
High
Throughput
Sequencing
if
still
gaining
new
knowledge
same
rate
before.
A
review
nanotechnology
is
provided
addressed.
Arbuscular
Mycorrhizal
Fungi
addressed
acknowledged.
Fungal
databases
becoming
important,
therefore
provide
major
databases.
Edible
medicinal
huge
medicines,
especially
Asia
prospects
discussed.
Lifestyle
changes
(e.g.,
endophytes,
pathogens,
and/or
saprobes)
also
extremely
trend
special
issue
Diversity.
Abstract
Background
As
antibiotics
and
chemotherapeutics
are
no
longer
as
efficient
they
once
were,
multidrug
resistant
(MDR)
pathogens
cancer
presently
considered
two
of
the
most
dangerous
threats
to
human
life.
In
this
study,
Selenium
nanoparticles
(SeNPs)
biosynthesized
by
Streptomyces
parvulus
MAR4,
nano-chitosan
(NCh),
their
nanoconjugate
(Se/Ch-nanoconjugate)
were
suggested
be
efficacious
antimicrobial
anticancer
agents.
Results
SeNPs
MAR4
NCh
successfully
achieved
conjugated.
The
spherical
with
a
mean
diameter
94.2
nm
high
stability.
Yet,
Se/Ch-nanoconjugate
was
semispherical
74.9
much
higher
SeNPs,
NCh,
showed
significant
activity
against
various
microbial
strong
inhibitory
effect
on
tested
metabolic
key
enzymes
[phosphoglucose
isomerase
(PGI),
pyruvate
dehydrogenase
(PDH),
glucose-6-phosphate
(G6PDH)
nitrate
reductase
(NR)];
powerful
agent.
Furthermore,
revealed
cytotoxicity
HepG2
(IC
50
=
13.04
μg/ml)
moderate
toxicity
Caki-1
(HTB-46)
tumor
cell
lines
21.35
but
low
WI-38
normal
line
85.69
μg/ml).
Nevertheless,
displayed
substantial
IC
values
11.82
7.83
μg/ml,
respectively.
Consequently,
may
more
easily
absorbed
both
lines.
However,
it
exhibited
very
153.3
μg/ml.
Therefore,
presented
activity.
Conclusion
convincingly
recommended
used
in
biomedical
applications
versatile
potent
agents
ensuring
notable
levels
biosafety,
environmental
compatibility,
efficacy.