Integration
of
bioelectronic
devices
in
clinical
practice
is
expanding
rapidly,
focusing
on
conditions
ranging
from
sensory
to
neurological
and
mental
health
disorders.
While
platinum
(Pt)
electrodes
neuromodulation
such
as
cochlear
implants
deep
brain
stimulators
have
shown
promising
results,
challenges
still
affect
their
long-term
performance.
Key
among
these
are
electrode
device
longevity
vivo,
formation
encapsulating
fibrous
tissue.
To
overcome
challenges,
organic
conductors
with
unique
chemical
physical
properties
being
explored.
They
hold
great
promise
coatings
for
neural
interfaces,
offering
more
rapid
regulatory
pathways
implementation
than
standalone
bioelectronics.
This
study
provides
a
comprehensive
review
the
potential
benefits
that
limit
effective
integration
into
existing
devices.
It
discusses
issues
related
metallic
use
introduces
physical,
electrical,
biological
applied
neuromodulation.
Furthermore,
previously
reported
coating
stability,
durability,
manufacturing,
biocompatibility
thoroughly
reviewed
proposed
adhesion
mechanisms
summarized.
Understanding
properties,
modifications,
current
industrial
settings
expected
provide
valuable
insights
future
development
Results in Chemistry,
Год журнала:
2024,
Номер
7, С. 101394 - 101394
Опубликована: Янв. 1, 2024
Titanium
has
an
extensive
record
of
serving
as
excellent
option
for
the
material
used
in
implant
construction.
It
been
demonstrated
that
certain
Ti
alloys
are
superior
to
other
types
every
respect.
Better
osseointegration
is
a
critical
component
implants,
and
titanium's
biocompatibility,
corrosion
tribology,
microstructure,
cell
adhesion
mechanism
have
subject
intensive
study
several
years.
Significant
strides
made
dental
research
thanks
company's
production
process,
analysis
material's
properties,
creation
new
innovative
alloys.
More
studies
should
be
done
at
dentistry
site
on
human
bone
determine
its
compatibility
with
metals
In
this
article,
we
will
discuss
latest
advancements
regarding
resistance,
mechanical
stability,
surface
chemistry,
electromechanical
behavior
titanium
implants.
addition
that,
also
recent
developments
production,
such
additive
manufacturing
technology,
well
characterization
techniques,
microstructure
characterization,
testing,
biocompatibility
tests,
clinical
use
Pharmaceutics,
Год журнала:
2022,
Номер
14(2), С. 455 - 455
Опубликована: Фев. 21, 2022
An
increase
in
the
world
population
and
its
life
expectancy,
as
well
ongoing
concern
about
our
physical
appearance,
have
elevated
relevance
of
dental
implantology
recent
decades.
Engineering
strategies
to
improve
survival
rate
implants
been
widely
investigated,
focusing
on
implant
material
composition,
geometry
(usually
guided
reduce
stiffness),
interface
surrounding
tissues.
Although
efforts
develop
different
surface
modifications
are
being
applied
commercial
prostheses
today,
inclusion
coatings
has
gained
special
interest,
they
can
be
tailored
efficiently
enhance
osseointegration,
bacterial-related
infection,
minimizing
peri-implantitis
appearance
associated
risks.
The
use
biomaterials
replace
teeth
highlighted
need
for
development
reliable
analytical
methods
assess
therapeutic
benefits
implants.
This
literature
review
considers
state-of-the-art
modification
or
coating
methodologies
increasing
restoration.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(31)
Опубликована: Ноя. 5, 2023
Abstract
Bacterial
infections
account
for
countless
deaths
globally.
Antibiotics
are
the
primary
countermeasure;
however,
alarming
spread
of
antibiotic‐resistant
strains
necessitates
alternative
solutions.
Silver
and
silver
compounds
have
emerged
as
promising
antibacterial
agents.
However,
issues
related
to
cytotoxicity
genotoxicity
remain
concern.
To
overcome
these
challenges,
this
proposes
an
easy‐to‐control
straightforward
method
synthesize
novel
Silver─gallium
(Ag─Ga)
nano‐amalgamated
particles.
Gallium
liquid
metal
(GaLM)
is
used
facilitate
galvanic
deposition
nanocrystals
(Ag)
on
oxide
layer.
The
GaLM
not
only
serves
a
carrier
through
replacement
process,
but
also
provides
controlled‐release
mechanism
silver,
in
way
improving
biocompatibility,
reducing
inflammation,
stimulating
bone
growth.
Notably,
Ag─Ga
suspensions
can
be
conveniently
deposited
by
spray‐coating
range
devices
material
surfaces,
effectively
eliminating
pathogenic
bacteria
with
efficacy
comparable
that
ions.
In
vivo
studies
rat
models
affirm
capabilities,
especially
against
methicillin‐resistant
Staphylococcus
aureus
Escherichia
coli
,
when
placed
implants
such
titanium
rods
magnesium
discs.
Furthermore,
promotes
matrix
formation
collagen
growth
without
eliciting
inflammatory
response,
indicating
major
promise
coatings
wide
variety
biomedical
materials.
Engineered Regeneration,
Год журнала:
2023,
Номер
5(1), С. 21 - 44
Опубликована: Окт. 27, 2023
Bone
fractures
are
common
occurrence
in
clinical
settings,
creating
a
high
demand
for
effective
repair
material.
Unfortunately,
limited
graft
availability,
donor
site
morbidities,
unpredictable
outcomes,
immunologic
reactions,
infection
risks,
and
geometrical
mismatching
concerns
hampered
tissue
use
underscored
the
need
scaffolds
more
bone
reconstructions
due
to
their
tunable
properties.
Significant
progress
has
been
carried
out
past
decade
fields
of
nanoceramics
synthesis,
bioconjugate
chemistry,
composite
material
processing.
This
review
outlines
hierarchical
structures
biology
tissue,
materialistic
components
(bioceramics,
polymers,
bioactive
drugs),
featured
scaffolding
strategies
(nanofibers,
hydrogels,
aerogels,
bioprinting,
fiber-reinforced
composite),
emphasis
that
physiochemical
characteristics
should
be
used
as
an
inspiration
scaffold
design.
discussed
how
differences
materiobiological
aspects
scaffolds,
such
polymer/bioceramic
nanocomposite,
mineralized
matrix-rich
3D
microenvironmental
cues,
pore
space
mechanical
usage
physical
stimulation
(magnetic,
electroactive,
photoactivated
cues),
surface
cues
(wettability,
roughness,
textured,
charge),
biointerface
(cell–biomaterial
interactions,
cell-selective
homing,
cell
regulatory
strategies)
modulate
cellular
biological
response
engineering.
study
further
challenges
benefits
integrating
Materials,
Год журнала:
2024,
Номер
17(21), С. 5157 - 5157
Опубликована: Окт. 23, 2024
Magnesium
(Mg)
has
attracted
considerable
attention
as
a
biodegradable
material
for
medical
implants
owing
to
its
excellent
biocompatibility,
mitigating
long-term
toxicity
and
stress
shielding.
Nevertheless,
challenges
arise
from
rapid
degradation
low
corrosion
resistance
under
physiological
conditions.
To
overcome
these
challenges,
titanium
(biocompatibility
resistance)
been
integrated
into
Mg.
The
incorporation
of
significantly
improves
mechanical
properties,
thereby
enhancing
performance
in
biological
settings.
Mg–Ti
alloys
are
produced
through
alloying
spark
plasma
sintering
(SPS).
SPS
technique
transforms
powder
mixtures
bulk
materials
while
preserving
structural
integrity,
resulting
enhanced
resistance,
particularly
Mg80-Ti20
alloy
simulated
body
fluids.
Moreover,
revealed
no
more
when
assessed
on
pre-osteoblastic
cells.
Furthermore,
the
ability
Mg–Ti-based
create
composites
with
polymers
such
PLGA
(polylactic-co-glycolic
acid)
widen
their
biomedical
applications
by
regulating
ensuring
pH
stability.
These
promote
temporary
orthopaedic
implants,
offering
initial
load-bearing
capacity
during
healing
process
fractures
without
requiring
second
surgery
removal.
address
scalability
constraints,
further
research
is
necessary
investigate
additional
consolidation
methods
beyond
SPS.
It
essential
evaluate
relationship
between
loading
confirm
adequacy
environments.
This
review
article
highlights
importance
characterization
evaluation
alloys,
reinforcing
applicability
fracture
fixation
various
implants.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Год журнала:
2023,
Номер
149, С. 106210 - 106210
