Bioprinting of self-healing materials and nanostructures for biomedical applications: Recent advances and progresses on fabrication and characterization techniques

Bioprinting, Год журнала: 2024, Номер 38, С. e00335 - e00335

Опубликована: Фев. 1, 2024

Язык: Английский

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Activating Macrophage Continual Efferocytosis via Microenvironment Biomimetic Short Fibers for Reversing Inflammation in Bone Repair

Advanced Materials, Год журнала: 2024, Номер 36(30)

Опубликована: Май 6, 2024

Abstract Efferocytosis‐mediated inflammatory reversal plays a crucial role in bone repairing process. However, refractory defects, the macrophage continual efferocytosis may be suppressed due to disrupted microenvironment homeostasis, particularly loss of apoptotic signals and overactivation intracellular oxidative stress. In this study, polydopamine‐coated short fiber matrix containing biomimetic “apoptotic signals” reconstruct reactivate for defect repair is presented. The (AM/CeO 2 ) are prepared using CeO nanoenzymes with neutrophil membrane coating recognition stress regulation. Additionally, “biomimetic matrix” utilized loading AM/CeO via abundant adhesion sites involving π – stacking hydrogen bonding interactions. Ultimately, implantable apoptosis‐mimetic nanoenzyme/short‐fiber matrixes (PFS@AM/CeO ), integrating matrixes, constructed facilitate reestablish pro‐efferocytosis microenvironment. vitro vivo data indicate that fibers can activate efferocytosis, leading suppression overactivated inflammation. enhanced rat femoral further demonstrates osteogenic potential strategy. It believed regulation through materials provide new perspective tissue repair.

Язык: Английский

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Harnessing bi-layered supramolecular Janus tissue-adhesive/anti-adhesive fibrous hydrogel for efficient hemostasis, wound healing, and suppressing postoperative tissue adhesion

Chemical Engineering Journal, Год журнала: 2024, Номер 495, С. 153095 - 153095

Опубликована: Июнь 13, 2024

Язык: Английский

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Cryogel Scaffolds for Tissue-Engineering: Advances and Challenges for Effective Bone and Cartilage Regeneration

Gels, Год журнала: 2023, Номер 9(12), С. 979 - 979

Опубликована: Дек. 14, 2023

Critical-sized bone defects and articular cartilage injuries resulting from trauma, osteonecrosis, or age-related degeneration can be often non-healed by physiological repairing mechanisms, thus representing a relevant clinical issue due to high epidemiological incidence rate. Novel tissue-engineering approaches have been proposed as an alternative common practices. This cutting-edge technology is based on the combination of three fundamental components, generally referred triad: autologous allogenic cells, growth-stimulating factors, scaffold. Three-dimensional polymer networks are frequently used scaffolds allow cell proliferation tissue regeneration. In particular, cryogels give promising results for this purpose, thanks their peculiar properties. Cryogels indeed characterized interconnected porous structure typical sponge-like behavior, which facilitate cellular infiltration ingrowth. Their composition fabrication procedure appropriately tuned obtain that match requirements specific organ regenerated. These features make interesting regeneration different tissues, including those very complex mechanical physical properties, such bones joints. review, state-of-the-art employment supporting effective osteogenic chondrogenic differentiation functional tissues reported. Current progress challenges implementation in practice also highlighted.

Язык: Английский

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The progressive trend of modeling and drug screening systems of breast cancer bone metastasis

Journal of Biological Engineering, Год журнала: 2024, Номер 18(1)

Опубликована: Фев. 5, 2024

Abstract Bone metastasis is considered as a considerable challenge for breast cancer patients. Various in vitro and vivo models have been developed to examine this occurrence. In are employed simulate the intricate tumor microenvironment, investigate interplay between cells their adjacent evaluate effectiveness of therapeutic interventions tumors. The endeavor replicate latency period bone animal has presented challenge, primarily due necessity primary removal presence multiple potential metastatic sites. utilization novel models, including three-dimensional (3D) proposed promising approach overcome constraints associated with conventional 2D models. However, existing 3D limited by various factors, such irregular cellular proliferation, autofluorescence, changes genetic epigenetic expression. imperative advancement future applications lies standardization automation. artificial intelligence exhibits capability predict behavior through examination substrate materials' chemical composition, geometry, mechanical performance. implementation these algorithms possesses progression proliferation cancer. This paper reviewed mechanisms following Current metastasis, along challenges, well perspectives using translational drug development, were discussed.

Язык: Английский

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A non-covalent binding strategy for the stabilization of fish collagen triple helices to promote its applications

Food Hydrocolloids, Год журнала: 2024, Номер 152, С. 109896 - 109896

Опубликована: Фев. 16, 2024

Язык: Английский

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Advancing 3D Dental Implant FEA: Incorporating Biomimetic Trabecular Bone with Varied Pore Sizes in Voronoi Lattices

Опубликована: Март 1, 2024

The human mandible's cancellous bone, which is characterized by its unique porosity and directional sensitivity to external forces, crucial for sustaining biting stress. Traditional CAD models fail fully represent bone's anisotropic structure thus depend on simple isotropic assumptions. For our research, we use the latest versions of nTopology Creo Parametric software make biomimetic Voronoi lattice that accurately reflect complex geometry mechanical properties trabecular bone. bone modeled in this work using models. porosities range from 70% 95%, can be achieved changing pore sizes 1.0 mm, 1.5 2.0 2.5 mm. Finite element analysis (FEA) was used examine displacements, stresses, strains acting dental implants with a buttress thread, abutment, retaining screw, load surface. results show model depicts anatomy jaw, compared standard solid block ideal size 2 taking into account both von Mises stress distribution over implant, screw retention, cortical micromotions. This displayed balanced performance successfully matching natural characteristics. Advanced finite improves biomechanical understanding how bones interact creating more accurate biological problems dynamic loading situations. makes engineering better.

Язык: Английский

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Calcium Phosphates: A Key to Next‐Generation In Vitro Bone Modeling

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(29)

Опубликована: Авг. 23, 2024

Abstract The replication of bone physiology under laboratory conditions is a prime target behind the development in vitro models. model should be robust enough to elicit an unbiased response when stimulated experimentally, giving reproducible outcomes. In tissue generation majorly requires availability cellular components, presence factors promoting proliferation and differentiation, efficient nutrient supply, supporting matrix for cells anchor – gaining predefined topology. Calcium phosphates (CaP) are difficult ignore while considering above requirements model. Therefore, current review focuses on role CaP developing addressing prerequisites generation. Special emphasis given physico‐chemical properties that promote osteogenesis, angiogenesis provide sufficient mechanical strength load‐bearing applications. Finally, future course action discussed ensure utilization field.

Язык: Английский

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An Injectable Hydrogel Composing Anti‐Inflammatory and Osteogenic Therapy toward Bone Erosions Microenvironment Remodeling in Rheumatoid Arthritis

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Июнь 25, 2024

Healing bone erosions in rheumatoid arthritis (RA) remains greatly challenging via biomaterial strategies. Given the unsuccessful innate erosion healing due to an inflammatory disorder, over-activated osteoclasts, and impaired osteoblasts differentiation, RA pathogenesis-guided engineering of innovative hydrogel platform is needed for remodeling osteoimmune osteogenic microenvironment healing. Herein, situ adaptable injectable interpenetrating polymer network (IPN) developed through ingenious combination a bio-orthogonal reaction between hyaluronic acid (HA) collagen, along with effective electrostatic interactions leveraging bisphosphonate (BP)-functionalized HA macromers (HABP) nanorod shaped zinc (Zn)-doped biphasic calcium phosphate (ZnBCP). IPN exhibits exceptional adaptability local shape complexity at erosions, by integrating ZnBCP HABP, multi-stage releasing engineered, facilitating controlled cargo delivery more anti-inflammatory M2 cells reducing osteoclastic activities, thereby reconstructing regeneration microenvironment. Sustainedly co-delivering multiple ions (calcium phosphate) can display excellent properties be conducive formation process, effects osteogenesis-associated cell differentiation. Overall, introduced bioactive therapy remodels environment synergistic pro-inflammation-resolving, osteogenesis, anti-osteoclastic displaying reconstruction collagen-induced rabbit model.

Язык: Английский

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3D-Printed Silk Proteins for Bone Tissue Regeneration and Associated Immunomodulation

Biomacromolecules, Год журнала: 2024, Номер 25(9), С. 5512 - 5540

Опубликована: Авг. 12, 2024

Current bone repair methods have limitations, prompting the exploration of innovative approaches. Tissue engineering emerges as a promising solution, leveraging biomaterials to craft scaffolds replicating natural environment, facilitating cell growth and differentiation. Among fabrication techniques, three-dimensional (3D) printing stands out for its ability tailor intricate scaffolds. Silk proteins (SPs), known their mechanical strength biocompatibility, are an excellent choice 3D-printed tissue (BTE) This article comprehensively reviews biology, 3D printing, unique attributes SPs, specifically detailing criteria scaffold such composition, structure, mechanics, cellular responses. It examines structural, mechanical, biological emphasizing suitability BTE. Recent studies on diverse approaches using SPs-based BTE highlighted, alongside advancements in four-dimensional (4D) role osteo-immunomodulation. Future directions use SPs outlined.

Язык: Английский

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