Integration
of
bioelectronic
devices
in
clinical
practice
is
expanding
rapidly,
focusing
on
conditions
ranging
from
sensory
to
neurological
and
mental
health
disorders.
While
platinum
(Pt)
electrodes
neuromodulation
such
as
cochlear
implants
deep
brain
stimulators
have
shown
promising
results,
challenges
still
affect
their
long-term
performance.
Key
among
these
are
electrode
device
longevity
vivo,
formation
encapsulating
fibrous
tissue.
To
overcome
challenges,
organic
conductors
with
unique
chemical
physical
properties
being
explored.
They
hold
great
promise
coatings
for
neural
interfaces,
offering
more
rapid
regulatory
pathways
implementation
than
standalone
bioelectronics.
This
study
provides
a
comprehensive
review
the
potential
benefits
that
limit
effective
integration
into
existing
devices.
It
discusses
issues
related
metallic
use
introduces
physical,
electrical,
biological
applied
neuromodulation.
Furthermore,
previously
reported
coating
stability,
durability,
manufacturing,
biocompatibility
thoroughly
reviewed
proposed
adhesion
mechanisms
summarized.
Understanding
properties,
modifications,
current
industrial
settings
expected
provide
valuable
insights
future
development
Biomimetics,
Год журнала:
2024,
Номер
9(11), С. 672 - 672
Опубликована: Ноя. 3, 2024
Bone
histology
and
histomorphometry
are
reliable
diagnostic
tools
for
the
assessment
of
bone-implant
interface,
material
safety
biocompatibility,
tissue
response.
They
allow
qualitative
quantitative
analysis
undecalcified
bone
specimens.
This
scoping
review
aims
to
identify
most
common
staining
techniques,
study
models
in
vivo
experiments,
histomorphometric
parameters
used
evaluation
osseointegrated
dental
implants
last
decade.
The
Web
Science,
PubMed,
Scopus
databases
were
searched
on
1
July
2024
relevant
articles
English,
published
ten
years,
data
exported
an
MS
Excel
spreadsheet.
A
total
115
studies
met
eligibility
criteria
included
present
review.
results
indicate
that
dogs,
rabbits,
pigs.
Some
frequently
methods
interface
Toluidine
blue,
Stevenel's
blue
with
Van
Gieson,
Levai-Laczko
stainings.
from
this
demonstrate
commonly
implant
dentistry
bone-to-implant
contact
(BIC),
area
fraction
occupancy
(BAFO),
(BA),
density
(BD).
presents
recent
trends
identifies
some
research
gaps
necessitate
further
research.
Integration
of
bioelectronic
devices
in
clinical
practice
is
expanding
rapidly,
focusing
on
conditions
ranging
from
sensory
to
neurological
and
mental
health
disorders.
While
platinum
(Pt)
electrodes
neuromodulation
such
as
cochlear
implants
deep
brain
stimulators
have
shown
promising
results,
challenges
still
affect
their
long-term
performance.
Key
among
these
are
electrode
device
longevity
vivo,
formation
encapsulating
fibrous
tissue.
To
overcome
challenges,
organic
conductors
with
unique
chemical
physical
properties
being
explored.
They
hold
great
promise
coatings
for
neural
interfaces,
offering
more
rapid
regulatory
pathways
implementation
than
standalone
bioelectronics.
This
study
provides
a
comprehensive
review
the
potential
benefits
that
limit
effective
integration
into
existing
devices.
It
discusses
issues
related
metallic
use
introduces
physical,
electrical,
biological
applied
neuromodulation.
Furthermore,
previously
reported
coating
stability,
durability,
manufacturing,
biocompatibility
thoroughly
reviewed
proposed
adhesion
mechanisms
summarized.
Understanding
properties,
modifications,
current
industrial
settings
expected
provide
valuable
insights
future
development
