Journal of Asian Natural Products Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 27
Опубликована: Фев. 24, 2025
Marine
fungi,
rich
in
unique
secondary
metabolites
with
diverse
activities,
are
a
valuable
source
for
novel
lead
compounds.
Steroids,
prominent
class
of
bioactive
compounds
from
marine
have
been
extensively
studied
their
pharmacological
properties.
This
review
describes
the
structural
diversity,
bioactivities,
and
sources
175
fungal
steroids
(2015-2023),
mainly
Aspergillus,
Penicillium,
Talaromyces,
etc.,
seaweed,
mangroves,
sediments,
animals
like
sponges
corals.
Among
them,
74
exhibit
antibacterial,
antitumor,
enzyme
inhibitory,
antiviral,
other
providing
leads
steroid
drug
development
advancing
pharmaceutical
research.
Marine Drugs,
Год журнала:
2023,
Номер
21(10), С. 538 - 538
Опубликована: Окт. 14, 2023
Three
new
polyketides
(penidihydrocitrinins
A–C,
1–3)
and
fourteen
known
compounds
(4–17)
were
isolated
from
the
deep-sea-derived
Penicillium
citrinum
W17.
Their
structures
elucidated
by
comprehensive
analyses
of
1D
2D
NMR,
HRESIMS,
ECD
calculations.
Compounds
1–17
evaluated
for
their
anti-inflammatory
anti-osteoporotic
bioactivities.
All
isolates
exhibited
significant
inhibitory
effects
on
LPS-stimulated
nitric
oxide
production
in
murine
brain
microglial
BV-2
cells
a
dose-response
manner.
Notably,
compound
14
displayed
strongest
effect
with
IC50
value
4.7
µM.
Additionally,
6,
7,
8
significantly
enhanced
osteoblast
mineralization,
which
was
comparable
to
that
positive
control,
purmorphamine.
Furthermore,
these
three
also
suppressed
osteoclastogenesis
dose-dependent
manner
under
concentrations
2.5
μM,
5.0
10
μM.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(8)
Опубликована: Апрель 29, 2024
Three
new
indole
alkaloids,
named
talatensindoids
A-C
(1-3),
together
with
two
known
biogenetically
related
alkaloids
tryptamine
(4)
and
L-tryptophan
(5)
were
isolated
from
the
Talaromyces
assiutensis
JTY2
based
on
guidance
of
OSMAC
approach.
The
structures
these
determined
by
comprehensive
spectroscopic
analyses.
absolute
configuration
3
was
confirmed
X-ray
crystallographic
analysis.
Compound
1
represent
rare
example
a
chlorine-substituted
alkaloid
natural
products.
inhibitory
activity
compounds
1-5
against
phytopathogenic
fungi
three
bacteria
evaluated.
exhibited
broad
spectrum
antibacterial
activities.
Frontiers in Marine Science,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 21, 2025
The
microbial
diversity
in
oceans
is
considerable,
widely
distributed
seawater,
marine
sediments,
and
organisms.
Compared
with
terrestrial
resources
traditional
natural
product
research,
the
living
environments
of
microorganisms
are
starkly
different.
drastic
differences
survival
conditions,
such
as
high
salinity,
oligotrophic
lack
light,
limited
oxygen,
determine
that
exhibit
distinctive
characteristics
metabolism,
modes,
adaptive
mechanisms.
These
factors
contribute
to
significant
distinctions
secondary
metabolic
pathways
enzymatic
reaction
mechanisms
between
microorganisms.
In
this
review,
we
summarized
a
total
72
novel
products
antibacterial
activity,
published
2024,
which
derived
from
marine-derived
fungi.
(polyketides,
alkaloids,
terpenoids,
peptides)
emphasized
terms
their
structures
biological
activities.
This
article
aims
provide
useful
information
for
research
development
antibiotics.
Journal of Asian Natural Products Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 27
Опубликована: Фев. 24, 2025
Marine
fungi,
rich
in
unique
secondary
metabolites
with
diverse
activities,
are
a
valuable
source
for
novel
lead
compounds.
Steroids,
prominent
class
of
bioactive
compounds
from
marine
have
been
extensively
studied
their
pharmacological
properties.
This
review
describes
the
structural
diversity,
bioactivities,
and
sources
175
fungal
steroids
(2015-2023),
mainly
Aspergillus,
Penicillium,
Talaromyces,
etc.,
seaweed,
mangroves,
sediments,
animals
like
sponges
corals.
Among
them,
74
exhibit
antibacterial,
antitumor,
enzyme
inhibitory,
antiviral,
other
providing
leads
steroid
drug
development
advancing
pharmaceutical
research.
