Bioactive steroids from marine-derived fungi: a review (2015–2023) DOI
Xueyang Ma,

Huan‐Nan Wang,

Lixiang Sun

и другие.

Journal of Asian Natural Products Research, Год журнала: 2025, Номер unknown, С. 1 - 27

Опубликована: Фев. 24, 2025

Marine fungi, rich in unique secondary metabolites with diverse activities, are a valuable source for novel lead compounds. Steroids, prominent class of bioactive compounds from marine have been extensively studied their pharmacological properties. This review describes the structural diversity, bioactivities, and sources 175 fungal steroids (2015-2023), mainly Aspergillus, Penicillium, Talaromyces, etc., seaweed, mangroves, sediments, animals like sponges corals. Among them, 74 exhibit antibacterial, antitumor, enzyme inhibitory, antiviral, other providing leads steroid drug development advancing pharmaceutical research.

Язык: Английский

Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities DOI Creative Commons
Yong Zhang,

Chun-Lan Xie,

Yuan Wang

и другие.

Marine Drugs, Год журнала: 2023, Номер 21(10), С. 538 - 538

Опубликована: Окт. 14, 2023

Three new polyketides (penidihydrocitrinins A–C, 1–3) and fourteen known compounds (4–17) were isolated from the deep-sea-derived Penicillium citrinum W17. Their structures elucidated by comprehensive analyses of 1D 2D NMR, HRESIMS, ECD calculations. Compounds 1–17 evaluated for their anti-inflammatory anti-osteoporotic bioactivities. All isolates exhibited significant inhibitory effects on LPS-stimulated nitric oxide production in murine brain microglial BV-2 cells a dose-response manner. Notably, compound 14 displayed strongest effect with IC50 value 4.7 µM. Additionally, 6, 7, 8 significantly enhanced osteoblast mineralization, which was comparable to that positive control, purmorphamine. Furthermore, these three also suppressed osteoclastogenesis dose-dependent manner under concentrations 2.5 μM, 5.0 10 μM.

Язык: Английский

Процитировано

9

Biogeochemical cycling of halogenated organic compounds in the ocean: Current progress and future directions DOI
Yuheng Liu, Li Wang, Rulong Liu

и другие.

Deep Sea Research Part I Oceanographic Research Papers, Год журнала: 2024, Номер 205, С. 104237 - 104237

Опубликована: Янв. 19, 2024

Язык: Английский

Процитировано

3

New Indole Alkaloids from the Fungus Talaromyces assiutensis JTY2 DOI
He Zhu,

Shuo Feng,

R R Xie

и другие.

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(8)

Опубликована: Апрель 29, 2024

Three new indole alkaloids, named talatensindoids A-C (1-3), together with two known biogenetically related alkaloids tryptamine (4) and L-tryptophan (5) were isolated from the Talaromyces assiutensis JTY2 based on guidance of OSMAC approach. The structures these determined by comprehensive spectroscopic analyses. absolute configuration 3 was confirmed X-ray crystallographic analysis. Compound 1 represent rare example a chlorine-substituted alkaloid natural products. inhibitory activity compounds 1-5 against phytopathogenic fungi three bacteria evaluated. exhibited broad spectrum antibacterial activities.

Язык: Английский

Процитировано

3

Marine fungi as a goldmine for novel antibiotics: a 2024 perspective DOI Creative Commons
Chengqian Pan,

Syed Shams ul Hassan,

Ishaq Muhammad

и другие.

Frontiers in Marine Science, Год журнала: 2025, Номер 11

Опубликована: Янв. 21, 2025

The microbial diversity in oceans is considerable, widely distributed seawater, marine sediments, and organisms. Compared with terrestrial resources traditional natural product research, the living environments of microorganisms are starkly different. drastic differences survival conditions, such as high salinity, oligotrophic lack light, limited oxygen, determine that exhibit distinctive characteristics metabolism, modes, adaptive mechanisms. These factors contribute to significant distinctions secondary metabolic pathways enzymatic reaction mechanisms between microorganisms. In this review, we summarized a total 72 novel products antibacterial activity, published 2024, which derived from marine-derived fungi. (polyketides, alkaloids, terpenoids, peptides) emphasized terms their structures biological activities. This article aims provide useful information for research development antibiotics.

Язык: Английский

Процитировано

0

Bioactive steroids from marine-derived fungi: a review (2015–2023) DOI
Xueyang Ma,

Huan‐Nan Wang,

Lixiang Sun

и другие.

Journal of Asian Natural Products Research, Год журнала: 2025, Номер unknown, С. 1 - 27

Опубликована: Фев. 24, 2025

Marine fungi, rich in unique secondary metabolites with diverse activities, are a valuable source for novel lead compounds. Steroids, prominent class of bioactive compounds from marine have been extensively studied their pharmacological properties. This review describes the structural diversity, bioactivities, and sources 175 fungal steroids (2015-2023), mainly Aspergillus, Penicillium, Talaromyces, etc., seaweed, mangroves, sediments, animals like sponges corals. Among them, 74 exhibit antibacterial, antitumor, enzyme inhibitory, antiviral, other providing leads steroid drug development advancing pharmaceutical research.

Язык: Английский

Процитировано

0