Advanced Therapeutics,
Год журнала:
2023,
Номер
6(9)
Опубликована: Июнь 24, 2023
Abstract
Recent
research
offers
several
approaches
for
the
advancement
of
manganese‐based
nanomaterials
its
therapeutic
use.
The
present
paper
reports
development
smartly
engineered
casein
manganese
oxide
nanobiomaterials
(CMnNP)
using
chloride
and
under
alkaline
condition
at
room
temperature.
CMnNP
are
systematically
characterized
by
various
analytical
techniques.
biocompatibility
these
is
observed
in
vitro
cell
viability
vivo
hemolysis
assay.
exhibit
pro‐angiogenic
properties,
established
through
assays
endothelial
cells
experiments.
interaction
with
different
enzymes
angiogenic
proteins
identified
silico
analysis
that
further
validated
western
blot
studies.
This
study
also
demonstrates
application
angiogenesis
wound
healing
as
well
hindlimb
ischemia
C57BL/6J
BALB/c
mouse
model,
respectively.
formation
redox
signaling
molecules
(especially
H
2
O
,
˙
−
NO)
may
be
one
plausible
mechanisms
CMnNP‐mediated
angiogenesis.
Considering
results,
current
a
nanomedical
perspective
therapy
ischemic
diseases
where
involves
crucial
step.
Biomaterials Research,
Год журнала:
2022,
Номер
26(1)
Опубликована: Июль 6, 2022
Theranostic
nanoplatforms
integrating
diagnostic
and
therapeutic
functions
have
received
considerable
attention
in
the
past
decade.
Among
them,
hollow
manganese
(Mn)-based
are
superior
since
they
combine
advantages
of
structures
intrinsic
theranostic
features
Mn
Nanoscale,
Год журнала:
2022,
Номер
14(38), С. 13950 - 13989
Опубликована: Янв. 1, 2022
Biosynthesized
MONPs
promote
plant
growth
via
improved
photosynthesis,
antioxidant
defense
activation
and
gene
upregulation.
Hence
they
can
be
used
as
nanofertilizers
further
applied
nanopesticides/antimicrobial
agents/nanobiosensors.
Journal of Materials Chemistry A,
Год журнала:
2023,
Номер
11(15), С. 7924 - 7948
Опубликована: Янв. 1, 2023
Critical
Mg–air
battery
researches
is
reviewed
on
mechanisms
and
electrode
materials.
The
effect
of
reaction
characteristics
performance
the
impact
energy
storage
material
design
are
discussed
with
emphasis.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Ноя. 21, 2023
Ferroptosis,
a
newly
characterized
form
of
regulated
cell
death,
is
induced
by
excessive
accumulation
lipid
peroxidation
catalyzed
intracellular
bioactive
iron.
Increasing
evidence
has
suggested
that
ferroptosis
involved
in
the
pathogenesis
several
human
diseases,
including
acute
liver
injury.
Targeted
inhibition
holds
great
promise
for
clinical
treatment
these
diseases.
Herein,
we
report
simple
and
one-pot
synthesis
ultrasmall
poly(acrylic)
acid
coated
Mn3O4
nanoparticles
(PAA@Mn3O4-NPs,
PMO),
which
perform
multiple
antioxidant
enzyme-mimicking
activities
can
scavenge
broad-spectrum
reactive
oxygen
species.
PMO
could
potently
suppress
ferroptosis.
Mechanistically,
after
being
absorbed
mainly
through
macropinocytosis,
are
largely
enriched
lysosomes,
where
detoxify
ROS,
inhibit
ferritinophagy-mediated
iron
mobilization
preserve
mTOR
activation,
collectively
confer
prominent
Additionally,
injection
counteracts
alleviates
acetaminophen-
ischaemia/reperfusion-induced
injury
mice.
Collectively,
our
results
reveal
biocompatible
act
as
potent
inhibitors
multifaceted
mechanisms,
ensures
have
translational
potential
ferroptosis-related
Biomedical Physics & Engineering Express,
Год журнала:
2023,
Номер
9(5), С. 052002 - 052002
Опубликована: Авг. 7, 2023
Abstract
Nanomedicine
and
nano-delivery
systems
hold
unlimited
potential
in
the
developing
sciences,
where
nanoscale
carriers
are
employed
to
efficiently
deliver
therapeutic
drugs
at
specifically
targeted
sites
a
controlled
manner,
imparting
several
advantages
concerning
improved
efficacy
minimizing
adverse
drug
reactions.
These
target-oriented
delivery
of
with
precision
site-specific,
mild
toxicity,
prolonged
circulation
time,
high
solubility,
long
retention
time
biological
system,
which
circumvent
problems
associated
conventional
approach.
Recently,
nanocarriers
such
as
dendrimers,
liposomes,
nanotubes,
nanoparticles
have
been
extensively
investigated
through
structural
characteristics,
size
manipulation,
selective
diagnosis
disease
imaging
molecules,
very
effective
introduce
new
paradigm
shift
drugs.
In
this
review,
use
nanomedicines
has
demonstrated
treating
various
diseases
significant
advances
applications
different
fields.
addition,
review
discusses
current
challenges
future
directions
for
research
these
promising
fields
well.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(14), С. 7564 - 7585
Опубликована: Март 27, 2024
Manganese
(Mn)
is
an
important
microelement
for
the
mineral
nutrition
of
plants,
but
it
not
effectively
absorbed
from
soil
and
salts
added
thereto
can
also
be
toxic
in
high
concentrations.
Mn
nanoparticles
(NPs)
are
less
toxic,
more
effective,
economical
than
due
to
their
nanosize.
This
article
critically
reviews
current
publications
on
NPs,
focusing
effects
plant
health,
growth,
stress
tolerance,
explaining
possible
mechanisms
effects.
review
provides
basic
information
examples
chemical,
physical,
ecological
("green")
methods
synthesis
NPs.
It
has
been
shown
that
protective
effect
NPs
associated
with
antioxidant
activity,
activation
systemic
acquired
resistance
(SAR),
pronounced
antimicrobial
activity
against
phytopathogens.
In
conclusion,
promising
agents
agriculture,
gene
expression
microbiome
require
further
research.
Critical Reviews in Analytical Chemistry,
Год журнала:
2025,
Номер
unknown, С. 1 - 21
Опубликована: Фев. 19, 2025
Manganese
is
an
essential
metal
ion
involved
in
various
biological
and
environmental
processes,
but
its
excess
can
lead
to
toxicity,
particularly
affecting
the
nervous
system.
Therefore,
developing
selective
sensitive
detection
methods
for
Mn2+
ions
of
paramount
importance.
Colorimetric
fluorimetric
chemosensors
have
emerged
as
promising
tools
due
their
simplicity,
cost-effectiveness,
real-time
monitoring
capabilities.
This
review
discusses
recent
advances
colorimetric
that
exhibit
distinct
color
or
fluorescence
changes
upon
interaction
with
ions.
The
explores
different
organic
nanomaterials,
focusing
on
mechanisms
sensing,
sensitivity,
selectivity,
practical
applications
monitoring,
healthcare,
food
safety.
article
also
provides
insights
into
future
research
directions
aimed
at
overcoming
these
challenges,
improving
chemosensor
performance,
expanding
applicability
diverse
real-world
scenarios.
