Materials Horizons, Год журнала: 2023, Номер 10(6), С. 2226 - 2236
Опубликована: Янв. 1, 2023
A biophotonic device is fabricated for employing a flexible OLED to excite conjugated polymer PPV in macrophage (M 0 )-laden 3D printed hydrogel, resulting the generation of ROS and subsequent M 1 polarization tumor immunotherapy.
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2008 - 2008
Опубликована: Янв. 19, 2023
Nanomaterials have been the focus of intensive development and research in medical industrial sectors over past several decades. Some studies found that these compounds can a detrimental impact on living organisms, including their cellular components. Despite obvious advantages using nanomaterials wide range applications, there is sometimes skepticism caused by lack substantial proof evaluates potential toxicities. The interactions nanoparticles (NPs) with cells immune system biomolecule pathways are an area interest for researchers. It possible to modify NPs so they not recognized or suppress stimulate targeted manner. In this review, we look at literature immunostimulation immunosuppression how changing physicochemical features particles could alter better worse (immunotoxicity). We also into whether unique unexpected (but desired) effect system, surface grafting polymers coatings makes stealth cannot find get rid of.
Язык: Английский
Процитировано
92
Exploration, Год журнала: 2024, Номер 4(6)
Опубликована: Март 24, 2024
Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.
Язык: Английский
Процитировано
37
Exploration, Год журнала: 2024, Номер 4(6)
Опубликована: Март 22, 2024
Abstract Metals are an emerging topic in cancer immunotherapy that have shown great potential modulating immunity cycle and promoting antitumor by activating the intrinsic immunostimulatory mechanisms which been identified recent years. The main challenge of metal‐assisted lies fact free metals as ion forms easily cleared during circulation, even cause systemic metal toxicity due to off‐target effects. With rapid development nanomedicine, metal‐based smart nanosystems (MSNs) with unique controllable structure become one most promising delivery carriers solve issue, owing their various endogenous/external stimuli‐responsiveness release ions for metalloimmunotherapy. In this review, state‐of‐the‐art research progress metal‐related is comprehensively summarized. First, mainstream MSNs‐assisted will be delineated. immunological effects certain categorization MSNs different characters compositions then provided, followed representative exemplar applications treatment, synergistic combination immunotherapy. Finally, we conclude review a summary remaining challenges associated provide authors' perspective on further advances.
Язык: Английский
Процитировано
23
Advanced Science, Год журнала: 2024, Номер 11(22)
Опубликована: Апрель 11, 2024
Abstract The inflammatory response is a key factor affecting tissue regeneration. Inspired by the immunomodulatory role of spermidine, an injectable double network hydrogel functionalized with spermidine (DN‐SPD) developed, where first and second networks are formed dynamic imine bonds non‐dynamic photo‐crosslinked respectively. single before photo‐crosslinking exhibits excellent injectability thus can be printed in situ to form hydrogels. DN‐SPD has demonstrated desirable mechanical properties adhesion. More importantly, “operando” comparison hydrogels loaded or diethylenetriamine (DETA), sham molecule resembling shown similar physical properties, but quite different biological functions. Specifically, outcomes 3 sets vivo animal experiments demonstrate that not only reduce inflammation caused implanted exogenous biomaterials reactive oxygen species also promote polarization macrophages toward regenerative M2 phenotype, DN‐DETA hydrogel. Moreover, immunoregulation translate into faster more natural healing both acute wounds diabetic wounds. Hence, local administration affords simple elegant approach attenuate foreign body reactions induced treat chronic refractory
Язык: Английский
Процитировано
21
ACS Applied Bio Materials, Год журнала: 2024, Номер 7(8), С. 5082 - 5106
Опубликована: Июль 15, 2024
In view of their exceptional approach, excellent inherent biocompatibility and biodegradability properties, interaction with the local extracellular matrix, protein-based polymers have received attention in bone tissue engineering, which is a multidisciplinary field that repairs regenerates fractured bones. Bone multihierarchical complex structure, it performs several essential biofunctions, including maintaining mineral balance structural support protecting soft organs. Protein-based gained interest developing ideal scaffolds as emerging biomaterials for healing regeneration, challenging to design substitutes perfect biomaterials. Several polymers, collagen, keratin, gelatin, serum albumin, etc., are potential materials due cytocompatibility, controlled biodegradability, high biofunctionalization, tunable mechanical characteristics. While numerous studies indicated encouraging possibilities proteins BTE, there still major challenges concerning stability physiological conditions, continuous release growth factors bioactive molecules. Robust derived from can be used replace broken or diseased biocompatible substitute; proteins, being biopolymers, provide engineering. Herein, recent developments protein cutting-edge engineering addressed this review within 3–5 years, focus on significant future perspectives. The first section discusses fundamentals anatomy scaffolds, second describes fabrication techniques scaffolds. third highlights importance applications BTE. Hence, development state-of-the-art has been discussed, highlighting
Язык: Английский
Процитировано
19
Small Methods, Год журнала: 2023, Номер 7(5)
Опубликована: Апрель 28, 2023
Abstract The immune system takes part in most physiological and pathological processes of the body, including occurrence development cancer. Immunotherapy provides a promising modality for inhibition even cure During immunotherapy, immunogenic cell death (ICD) tumor cells induced by chemotherapy, radiotherapy, phototherapy, bioactive materials, so forth, triggers series cellular responses causing release tumor‐associated antigens damage‐associated molecular patterns, which ultimately activate innate adaptive responses. Among them, ICD‐induced biomaterials attract increasing conditions as benefit biosafety multifunctional modifications. This Review summarizes research progress inducing ICD via triggering endoplasmic reticulum oxidative stress, mitochondrial dysfunction, membrane rupture discusses application prospects ICD‐inducing clinical practice cancer immunotherapy.
Язык: Английский
Процитировано
39
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 161, С. 114431 - 114431
Опубликована: Фев. 22, 2023
Ferroptosis has emerged as a therapeutic tactic to trigger cancer cell death driven by abnormal accumulation of reactive oxygen species (ROS). However, single ferroptosis treatment modality is often limited. In this work, combination therapy and immunotherapy for was proposed. Specifically, versatile nanodrug designed the multiple hepatocellular carcinoma (HCC) loading dihydroartemisinin (DHA) on Fe3+-doped MnO2 nanosheets (Fe-MnO2/DHA). Firstly, Fe-MnO2/DHA degraded glutathione (GSH) in tumor microenvironment (TME) release Fe2+, Mn2+ DHA, leading aberrant ROS due Fenton/Fenton-like reaction. Secondly, breakage endoperoxide bridge from DHA caused Fe2+ further induce oxidative stress. Thirdly, depleted GSH promoted inactivation peroxidase 4 (GPX4), resulting lipid peroxide (LPO) accumulation. The LPO could apoptosis liver cells. Furthermore, mediated three-pronged stimulation stress, high levels targeted immunogenic (ICD). It enhance infiltration CD4+ T CD8+ cells, promote macrophage polarization. also acted an immunomodulator inhibit regulatory cells (Tregs) systemic antitumor. Overall, presents multi-modal HCC ferroptosis, immune activation, significantly advancing synergistic treatment.
Язык: Английский
Процитировано
28
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(12)
Опубликована: Фев. 1, 2024
Diabetic wounds are a prevalent and devastating complication of diabetes, which may impede their healing regeneration. In diabetic wounds, excess reactive oxygen species (ROS) activate the nuclear factor kappa-B pathway, leading to transcriptional silencing erythroid 2-related 2 (Nrf2), resulting in vicious cycle oxidative stress inflammation. Conventional nanozymes have limitations preventing continuous production ROS, including most oxidizing hydroxyl radical (·OH), although they can remove pre-existing ROS. Herein, novel antioxidant nanoplatform addresses this challenge by incorporating JSH-23 into mesoporous cupric-doped cerium oxide nanozymes. Additionally, for rapid wound adaptability durable tissue adhesion, nanozyme hydrogel spray consisting oxidized sodium alginate methacrylate gelatin is constructed, named OG@CCJs. This platform resurrects Nrf2 activity macrophages vitro, curbing ROS at its source, particularly ·OH, while enabling scavenge previously generated OG@CCJs significantly alleviate vivo, promoting healing. Overall, proposed nanozyme-hydrogel with enhanced ·OH-scavenging uses "two-track" strategy rebuild defense barrier macrophages. pioneering approach highlights tremendous potential facilitating
Язык: Английский
Процитировано
10
Accounts of Chemical Research, Год журнала: 2023, Номер 56(13), С. 1766 - 1779
Опубликована: Июнь 14, 2023
ConspectusDevelopment of multifunctional nanoparticles (NPs) with desired properties is a significant topic in the field nanotechnology and has been anticipated to revolutionize cancer diagnosis treatment modalities. The surface character one most important parameters NPs that can directly affect their vivo fate, bioavailability, final theranostic outcomes thus should be carefully tuned maximize effects while minimizing unwanted side effects. Surface engineered have utilized various functionality types approaches meet requirements therapy imaging. Despite strategies, these modifications generally serve similar purposes, namely, introducing therapeutic/imaging modules, improving stability circulation, enhancing targeting ability, achieving controlled functions. These hence could applied scenarios continuously contribute clinical translation next-generation NP-based platforms toward theranostics.In this Account, we present recent advances research efforts on development NP engineering theranostics. First, summarize general strategies for engineering. Various functionalities including inorganic material-based functionality, organic like small molecules, polymers, nucleic acids, peptides, proteins, carbohydrates, antibodies, etc., biomembrane-based functionality. realized by prefabrication or postfabrication functionalization, driven covalent conjugations noncovalent interactions. Second, highlight aims different functionalities. Different therapeutic diagnostic such as nanozymes, imaging contrast agents, modified achieve function. modification also improve circulation protecting from immune recognition clearance. In addition, targeted imaging, moieties attached enhance active ability tissues cells interest. Furthermore, surfaces tailored functions which only respond specific internal (e.g., pH, thermal, redox, enzyme, hypoxia) external light, ultrasound) triggers at precise action sites. Finally, our perspective remaining challenges future developments rapidly evolving field. We hope Account offer an insightful overlook progress illuminating prospect advanced promoting more attention area adoption scientists fields, accelerating solid foundation broad theranostics applications.
Язык: Английский
Процитировано
21
International Journal of Pharmaceutics, Год журнала: 2023, Номер 634, С. 122655 - 122655
Опубликована: Янв. 30, 2023
Язык: Английский
Процитировано
18