European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 31, 2024
Abstract
Cyclic
N
‐sulfonyl
ketimines
constitute
an
accessible
class
of
lead‐like
heterocycles
with
a
vast
application
in
both
synthetic
organic
and
medicinal
chemistry.
In
this
context,
we
harness
the
capabilities
these
four
different
isocyanide‐based
multicomponent
reactions.
Our
goal
was
to
create
libraries
compounds
functional
groups
vectors
that
are
compatible
for
structural
elaboration
optimization
their
physical
properties.
We
synthesized
15
unprecedented
high
diversity
complexity,
whereas
have
obtained
single
crystal
structures
each
scaffold,
unraveling
geometrical
features
potential
employment
drug
discovery.
Organic Letters,
Год журнала:
2021,
Номер
24(1), С. 299 - 303
Опубликована: Дек. 16, 2021
A
sustainable
and
cost-effective
manner
for
the
photocatalytic
annulation
reaction
of
N-sulfonyl
ketimines
with
N-arylglycines
to
synthesize
imidazolidine-fused
sulfamidates
(31
examples)
by
employing
CsPbBr3
as
a
heterogeneous
photocatalyst
has
been
developed.
The
catalyst
can
be
simply
recovered
from
mixture
reused
at
least
five
times
without
an
obvious
reduction
in
its
reactivity,
exhibiting
high
economic
feature.
Chemical Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
silver-catalyzed
cross
coupling
of
cyclic
aldimines
and
α-imino-oxy
acids
has
been
developed.
The
solvent-dependent
reaction
could
selectively
deliver
either
imine
moiety
retained
nitriles
or
ring-opened
oxonitriles
in
moderate
yields.
Green Chemistry,
Год журнала:
2022,
Номер
24(21), С. 8377 - 8385
Опубликована: Янв. 1, 2022
An
efficient
and
eco-friendly
electrochemical
synthesis
of
various
cyclic
N
-sulfonylamidines
from
sulfamidate
imines
amines
via
oxidative
C–H/N–H
cross-coupling
under
mild
reaction
conditions
has
been
developed.
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(18), С. 3798 - 3802
Опубликована: Янв. 1, 2022
A
visible-light-induced
metal-free
cascade
cyclization
of
cyclic
N-sulfonyl
ketimines
with
N-arylglycines
for
the
construction
N-sulfonamide-fused
imidazolidines
was
developed.
The
procedure
employed
3
mol%
eosin
Y
as
photocatalyst
at
room
temperature
under
visible
light
irradiation,
providing
various
in
good
yields
(32
examples,
up
to
86%
yields).
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(24), С. 18337 - 18343
Опубликована: Дек. 9, 2024
A
cerium-catalyzed
C–H
alkylation
of
N-sulfonyl
ketimines
with
low-cost
and
readily
available
alkanes
as
alkyl
sources
was
developed.
This
transformation
proceeded
through
the
synergy
photoinitiated
ligand-to-metal
charge
transfer
(LMCT)
using
a
chlorine
radical
an
HAT
reagent
air
green
oxidant.
series
alkylated
were
synthesized
moderate
to
good
yields
in
highly
atom-economic
manner
under
chemical
oxidant-free
conditions.
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(15)
Опубликована: Март 6, 2023
Abstract
An
efficient
and
straightforward
protocol
for
accessing
a
new
series
of
functionalized
4‐aminocoumarins
from
PIDA/I
2
‐mediated
decarboxylative
C
4
‐amination
coumarin‐3‐carboxylic
acids
via
direct
sp2
−H
dehydrogenative
C−N
cross‐coupling
with
secondary
amines
under
ambient
conditions
has
been
accomplished.
The
notable
advantages
this
are
the
tolerance
diverse
functional
groups,
mild
reaction
at
temperature,
moderate
to
good
yields,
short
times
(in
minutes),
high
regioselectivity,
gram‐scale
applicability,
eco‐friendliness.
This
is
first
report
cross‐dehydrogenative
coupling
synthesizing
4‐aminocoumarins.
Green Synthesis and Catalysis,
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 1, 2023
We
first
describe
a
photoinduced
decatungstate-catalyzed
direct
coupling
of
cycloalkanes
and
cyclic
aldimines.
The
desired
products
were
generated
in
moderate
to
good
yields
with
wide
substrate
scope
under
mild
reaction
conditions.
mechanistic
study
revealed
radical
process.
In
addition,
the
usefulness
organic
synthesis
was
proved
by
scale-up
as
well
late-stage
modification
drug-like
molecules.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(13), С. 2700 - 2704
Опубликована: Янв. 1, 2023
A
silver-catalyzed
cyclization
of
α-imino-oxy
acids
under
mild
conditions
has
been
described.
This
reaction
offers
facile
access
to
a
diverse
range
fused
tetralone
derivatives
with
exquisite
stereoselectivity
in
moderate
good
yields.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(24), С. 4544 - 4549
Опубликована: Ноя. 22, 2023
Abstract
The
air
mediated
radical
alkylation
of
cyclic
aldimines
via
autoxidation
alkylboronic
acids
has
been
realized
under
mild
reaction
conditions.
By
simply
heating
with
acid
using
as
sole
oxidant,
this
protocol
provides
a
catalyst‐free
access
to
variety
alkylated
21–91%
yields.
Preliminary
mechanistic
studies
suggest
that
pathway
might
be
involved
in
the
reaction.
