Rational Molecular Editing: A New Paradigm in Drug Discovery

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(14), С. 11459 - 11466

Опубликована: Июнь 21, 2024

ADVERTISEMENT RETURN TO ARTICLES ASAPPREVEditorialNEXTRational Molecular Editing: A New Paradigm in Drug DiscoveryChunhua MaChunhua MaState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA for Research and Evaluation Innovative Drug, School Chemistry Chemical Engineering, Henan Normal University, Xinxiang, 453007, ChinaMore by Chunhua Mahttps://orcid.org/0000-0001-7613-6471, Craig W. Lindsley*Craig LindsleyVanderbilt University Medical Center, Franklin, Tennessee 37027, United States*E-mail: [email protected]More Lindsleyhttps://orcid.org/0000-0003-0168-1445, Junbiao Chang*Junbiao ChangCollege Chemistry, State Zhengzhou 450001, China*E-mail: Chang, Bin Yu*Bin YuCollege Yuhttps://orcid.org/0000-0002-7207-643XCite this: J. Med. Chem. 2024, XXXX, XXX, XXX-XXXPublication Date (Web):June 21, 2024Publication History Received13 June 2024Published online21 2024https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01347https://doi.org/10.1021/acs.jmedchem.4c01347editorialACS PublicationsPublished 2024 American Society. This publication is available under these Terms Use. Request reuse permissions free to access through this site. Learn MoreArticle Views-Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail (2 MB) Get e-AlertscloseSUBJECTS:Drug discovery,Macrocyclization,Molecules,Pharmaceuticals,Scaffolds e-Alerts

Язык: Английский

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Electrochemical regioselective synthesis of N-substituted/unsubstituted 4-selanylisoquinolin-1(2H)-ones

Chinese Chemical Letters, Год журнала: 2021, Номер 33(3), С. 1501 - 1504

Опубликована: Авг. 19, 2021

Язык: Английский

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Visible light-induced functionalization of indazole and pyrazole: a recent update

Chemical Communications, Год журнала: 2022, Номер 58(28), С. 4435 - 4455

Опубликована: Янв. 1, 2022

Indazole and pyrazole are renowned as a prodigious class of heterocycles having versatile uses in medicinal well industrial chemistry. Considering sustainable approaches, recently, photocatalysis has become an indispensable tool organic chemistry due to its application for the activation small molecules use clean energy source. In this review, we have highlighted metal-based photocatalysts, photoredox catalysts, transfer photocatalysts electron-donor-acceptor complexes functionalization indazole pyrazole. This perspective is arranged based on types reactions A detailed discussion regarding reaction mechanism each given provide comprehensive guide reader. Finally, summary existing challenges future outlook towards development efficient photocatalytic methods these also presented.

Язык: Английский

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Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis

CHINESE JOURNAL OF CATALYSIS (CHINESE VERSION), Год журнала: 2022, Номер 43(3), С. 571 - 583

Опубликована: Фев. 2, 2022

Язык: Английский

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Visible-light-induced direct 3-ethoxycarbonylmethylation of 2-aryl-2H-indazoles in water

Organic Chemistry Frontiers, Год журнала: 2022, Номер 9(5), С. 1445 - 1450

Опубликована: Янв. 1, 2022

A visible-light-driven rhodamine B-catalyzed transition-metal-free 3-ethoxycarbonylmethylation of 2-aryl-2 H -indazoles and imidazo[1,2- a ]pyridines (40 examples) using commercially available α-bromoesters was realized in water.

Язык: Английский

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Visible-Light Photocatalyzed C3–H Alkylation of 2H-Indazoles/Indoles with Sulfoxonium Ylides via Diversified Mechanistic Pathways

ACS Catalysis, Год журнала: 2024, Номер 14(2), С. 1193 - 1204

Опубликована: Янв. 9, 2024

Herein, the C3–H alkylation of 2H-indazoles and indoles with sulfoxonium ylides is developed under visible-light photocatalysis. This protocol employs easily accessible reagents, a wide range 2H-indazoles, indoles, are suitable for this reaction to afford desired products benign conditions. Synergistic experimental computational studies suggest that involving photocatalysis could proceed via different mechanistic pathways. For C3-alkylation triplet energy transfer pathway proposed quenching excited photocatalyst. Subsequently, formed state undergo radical attack on C═S moiety ylides. After dissociation DMSO 1,2-H migration, final product be yielded. However, such not applicable indoles. Instead, converted C-centered in presence KH2PO4 photoredox The can C3-site thus lead

Язык: Английский

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Recent advances in the photocatalytic synthesis of aldehydes

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(16), С. 4198 - 4210

Опубликована: Янв. 1, 2023

This review summarizes the recently developed photocatalytic strategies for installation of formyl group into various scaffolds.

Язык: Английский

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Photochemical reactions as synthetic tool for pharmaceutical industries

Chinese Chemical Letters, Год журнала: 2024, Номер 35(9), С. 109498 - 109498

Опубликована: Янв. 6, 2024

Язык: Английский

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Advances of N-Hydroxyphthalimide Esters in Photocatalytic Alkylation Reactions

Chinese Journal of Organic Chemistry, Год журнала: 2021, Номер 41(12), С. 4661 - 4661

Опубликована: Янв. 1, 2021

N-Hydroxyphthalimide (NHP) esters are easily available, stable, inexpensive, and highly photoactive compounds, which derived from the corresponding carboxylic acids.In recent years, application of NHP in photocatalytic decarboxylative reactions has captured huge attention.Herein, vigorous development alkylation using alkyl as alkylating reagents is summarized based on classification photocatalysts.

Язык: Английский

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Visible-Light-Driven Transition-Metal-Free Site-Selective Access to Isonicotinamides

Organic Letters, Год журнала: 2022, Номер 24(45), С. 8265 - 8270

Опубликована: Ноя. 7, 2022

The greener synthesis of N-substituted isonicotinamides is high importance and remains a significant challenge to the chemistry community. Herein we delineated visible-light-driven, transition-metal-free, external-oxidant-free radical-radical cross-coupling reaction access via consecutive photoinduced electron transfer (ConPET). utility this protocol highlighted through N-terminal modification peptides late-stage drugs.

Язык: Английский

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