Frontiers in Chemistry,
Год журнала:
2022,
Номер
10
Опубликована: Июль 13, 2022
A
visible-light-promoted
transition-metal-free
perfluoroalkylation/cyclization
reaction
was
developed
with
9-mesityl-10-methylacridinium
perchlorate
(Acr+-Mes·ClO4-)
as
the
photocatalyst,
by
which
various
perfluoroalkyl-substituted
heterocycles
including
thioflavones,
oxindoles,
and
quinoline-2,4(1H,3H)-diones
were
prepared
at
room
temperature.
Moreover,
potential
of
this
sustainable
method
is
demonstrated
excellent
in
vitro
anti-lymphoma
cervical
carcinoma
activity
novel
3-perfluoroalkylated
thioflavone
3m.
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(14), С. 11459 - 11466
Опубликована: Июнь 21, 2024
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TO
ARTICLES
ASAPPREVEditorialNEXTRational
Molecular
Editing:
A
New
Paradigm
in
Drug
DiscoveryChunhua
MaChunhua
MaState
Key
Laboratory
of
Antiviral
Drugs,
Pingyuan
Laboratory,
NMPA
for
Research
and
Evaluation
Innovative
Drug,
School
Chemistry
Chemical
Engineering,
Henan
Normal
University,
Xinxiang,
453007,
ChinaMore
by
Chunhua
Mahttps://orcid.org/0000-0001-7613-6471,
Craig
W.
Lindsley*Craig
LindsleyVanderbilt
University
Medical
Center,
Franklin,
Tennessee
37027,
United
States*E-mail:
[email
protected]More
Lindsleyhttps://orcid.org/0000-0003-0168-1445,
Junbiao
Chang*Junbiao
ChangCollege
Chemistry,
State
Zhengzhou
450001,
China*E-mail:
Chang,
Bin
Yu*Bin
YuCollege
Yuhttps://orcid.org/0000-0002-7207-643XCite
this:
J.
Med.
Chem.
2024,
XXXX,
XXX,
XXX-XXXPublication
Date
(Web):June
21,
2024Publication
History
Received13
June
2024Published
online21
2024https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01347https://doi.org/10.1021/acs.jmedchem.4c01347editorialACS
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2024
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Chemical Communications,
Год журнала:
2022,
Номер
58(28), С. 4435 - 4455
Опубликована: Янв. 1, 2022
Indazole
and
pyrazole
are
renowned
as
a
prodigious
class
of
heterocycles
having
versatile
uses
in
medicinal
well
industrial
chemistry.
Considering
sustainable
approaches,
recently,
photocatalysis
has
become
an
indispensable
tool
organic
chemistry
due
to
its
application
for
the
activation
small
molecules
use
clean
energy
source.
In
this
review,
we
have
highlighted
metal-based
photocatalysts,
photoredox
catalysts,
transfer
photocatalysts
electron-donor-acceptor
complexes
functionalization
indazole
pyrazole.
This
perspective
is
arranged
based
on
types
reactions
A
detailed
discussion
regarding
reaction
mechanism
each
given
provide
comprehensive
guide
reader.
Finally,
summary
existing
challenges
future
outlook
towards
development
efficient
photocatalytic
methods
these
also
presented.
Organic Chemistry Frontiers,
Год журнала:
2022,
Номер
9(5), С. 1445 - 1450
Опубликована: Янв. 1, 2022
A
visible-light-driven
rhodamine
B-catalyzed
transition-metal-free
3-ethoxycarbonylmethylation
of
2-aryl-2
H
-indazoles
and
imidazo[1,2-
a
]pyridines
(40
examples)
using
commercially
available
α-bromoesters
was
realized
in
water.
ACS Catalysis,
Год журнала:
2024,
Номер
14(2), С. 1193 - 1204
Опубликована: Янв. 9, 2024
Herein,
the
C3–H
alkylation
of
2H-indazoles
and
indoles
with
sulfoxonium
ylides
is
developed
under
visible-light
photocatalysis.
This
protocol
employs
easily
accessible
reagents,
a
wide
range
2H-indazoles,
indoles,
are
suitable
for
this
reaction
to
afford
desired
products
benign
conditions.
Synergistic
experimental
computational
studies
suggest
that
involving
photocatalysis
could
proceed
via
different
mechanistic
pathways.
For
C3-alkylation
triplet
energy
transfer
pathway
proposed
quenching
excited
photocatalyst.
Subsequently,
formed
state
undergo
radical
attack
on
C═S
moiety
ylides.
After
dissociation
DMSO
1,2-H
migration,
final
product
be
yielded.
However,
such
not
applicable
indoles.
Instead,
converted
C-centered
in
presence
KH2PO4
photoredox
The
can
C3-site
thus
lead
Chinese Journal of Organic Chemistry,
Год журнала:
2021,
Номер
41(12), С. 4661 - 4661
Опубликована: Янв. 1, 2021
N-Hydroxyphthalimide
(NHP)
esters
are
easily
available,
stable,
inexpensive,
and
highly
photoactive
compounds,
which
derived
from
the
corresponding
carboxylic
acids.In
recent
years,
application
of
NHP
in
photocatalytic
decarboxylative
reactions
has
captured
huge
attention.Herein,
vigorous
development
alkylation
using
alkyl
as
alkylating
reagents
is
summarized
based
on
classification
photocatalysts.
Organic Letters,
Год журнала:
2022,
Номер
24(45), С. 8265 - 8270
Опубликована: Ноя. 7, 2022
The
greener
synthesis
of
N-substituted
isonicotinamides
is
high
importance
and
remains
a
significant
challenge
to
the
chemistry
community.
Herein
we
delineated
visible-light-driven,
transition-metal-free,
external-oxidant-free
radical-radical
cross-coupling
reaction
access
via
consecutive
photoinduced
electron
transfer
(ConPET).
utility
this
protocol
highlighted
through
N-terminal
modification
peptides
late-stage
drugs.
